ID A0A2K5KTW4_CERAT Unreviewed; 160 AA.
AC A0A2K5KTW4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Peripheral myelin protein 22 {ECO:0000256|ARBA:ARBA00015663, ECO:0000256|RuleBase:RU363088};
GN Name=PMP22 {ECO:0000313|Ensembl:ENSCATP00000004127.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000004127.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000004127.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Might be involved in growth regulation, and in myelinization
CC in the peripheral nervous system. {ECO:0000256|ARBA:ARBA00002422,
CC ECO:0000256|RuleBase:RU363088}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU363088}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU363088}.
CC -!- SIMILARITY: Belongs to the PMP-22/EMP/MP20 family.
CC {ECO:0000256|ARBA:ARBA00006864, ECO:0000256|RuleBase:RU363088}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU363088}.
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DR RefSeq; XP_011905661.1; XM_012050271.1.
DR RefSeq; XP_011905670.1; XM_012050280.1.
DR STRING; 9531.ENSCATP00000004132; -.
DR Ensembl; ENSCATT00000017067.1; ENSCATP00000004127.1; ENSCATG00000014988.1.
DR Ensembl; ENSCATT00000017075.1; ENSCATP00000004132.1; ENSCATG00000014988.1.
DR GeneID; 105581264; -.
DR KEGG; caty:105581264; -.
DR CTD; 5376; -.
DR GeneTree; ENSGT00950000182696; -.
DR OMA; HTADLWQ; -.
DR OrthoDB; 5356024at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000014988; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006915; P:apoptotic process; IEA:Ensembl.
DR GO; GO:0032060; P:bleb assembly; IEA:Ensembl.
DR Gene3D; 1.20.140.150; -; 1.
DR InterPro; IPR003936; PMP22.
DR InterPro; IPR004031; PMP22/EMP/MP20/Claudin.
DR InterPro; IPR004032; PMP22_EMP_MP20.
DR PANTHER; PTHR10671; EPITHELIAL MEMBRANE PROTEIN-RELATED; 1.
DR PANTHER; PTHR10671:SF7; PERIPHERAL MYELIN PROTEIN 22; 1.
DR Pfam; PF00822; PMP22_Claudin; 1.
DR PRINTS; PR01453; EPMEMFAMILY.
DR PRINTS; PR01458; PMYELIN22.
DR PROSITE; PS01221; PMP22_1; 1.
DR PROSITE; PS01222; PMP22_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU363088};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU363088};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU363088};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT TRANSMEM 65..84
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363088"
FT TRANSMEM 96..117
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363088"
FT TRANSMEM 137..156
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU363088"
SQ SEQUENCE 160 AA; 17861 MW; E9B9A617453809F2 CRC64;
MLLLLLGIIV LHVAVLVLLF VSTIVSQWIV GNGHATDLWQ NCSTSSSGNV HHCFSSSPNE
WLQSVQATMI LSIIFSVLSL FLFFCQLFTL TKGGRFYITG IFQILAGLCV MSAAAIYTVR
HPEWHLNTDY SYGFAYILAW VAFPLALLSG VIYVILRKRE
//
