ID A0A2K5KU29_CERAT Unreviewed; 1068 AA.
AC A0A2K5KU29;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 33.
DE RecName: Full=TSC22 domain family protein 1 {ECO:0000256|ARBA:ARBA00039911};
GN Name=TSC22D1 {ECO:0000313|Ensembl:ENSCATP00000004188.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000004188.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000004188.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TSC-22/Dip/Bun family.
CC {ECO:0000256|ARBA:ARBA00007908}.
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DR RefSeq; XP_011919762.1; XM_012064372.1.
DR AlphaFoldDB; A0A2K5KU29; -.
DR STRING; 9531.ENSCATP00000004188; -.
DR Ensembl; ENSCATT00000017221.1; ENSCATP00000004188.1; ENSCATG00000015087.1.
DR GeneID; 105587798; -.
DR KEGG; caty:105587798; -.
DR CTD; 8848; -.
DR GeneTree; ENSGT00940000159144; -.
DR OMA; EDSGHQQ; -.
DR OrthoDB; 2965073at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000015087; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0043065; P:positive regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:1901390; P:positive regulation of transforming growth factor beta activation; IEA:Ensembl.
DR GO; GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR CDD; cd21938; ZIP_TSC22D1; 1.
DR Gene3D; 1.20.5.490; Single helix bin; 1.
DR InterPro; IPR000580; TSC22/Bun.
DR InterPro; IPR047862; TSC22/BUN_CS.
DR PANTHER; PTHR46745; TSC22 DOMAIN FAMILY PROTEIN 1; 1.
DR PANTHER; PTHR46745:SF1; TSC22 DOMAIN FAMILY PROTEIN 1; 1.
DR Pfam; PF01166; TSC22; 1.
DR SUPFAM; SSF58026; Delta-sleep-inducing peptide immunoreactive peptide; 1.
DR PROSITE; PS01289; TSC22; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT REGION 23..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..623
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 827..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1032..1068
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 991..1025
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 35..59
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 60..84
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..99
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 172..188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 216..238
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 257..288
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..619
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1068 AA; 108984 MW; E4F48055CF19AA98 CRC64;
MHQPPESTAA AAAAADISAR KMAHPAVFPR RGSGSGSASA LNAAGTGVGS SATSSEDFPP
PSLLQPPPPA ASSTSGPQPP PPQSLNLLSQ AQLQAQPLAP GGTQMKKKSG FQITSVTPAQ
ISASISSNNS IAEDTESYDD LDESHTEDLS SSEILDVSLS RATDLGEPER SSSEETLNNF
QEAETPGAVS PNQPHLPQPH LPHLPQQNVV INGNAHPHHL HHHHHIHHGH HLQHGHHHPS
HVAVASASIP GGPPSSPVSR KLSTTGSSDS ITPVAPTSAV SSSGSPASVM TNIRAPSTTG
GIGISSVTGT STVNNVNITA VGSLNPNMTS SMLGNANIST SNIPSAASVS VGPGVTSGVN
VNILSGMGNG TISSSAAVSS VPNAAAGMTG GSVSSQQQQP TVNTSRFRVV KLDSSSEPFK
KGRWTCTEFY EKENAVPATE GVLINKVVET VKQNPIEVTS ERESTSGSSV SSSVSTLSHY
TESVGSGEMG APTVVVQQQQ QQQQPALQGV TLQQMDFGST GPQSIPAVSI PQSISQSQIS
QVQLQSQELS YQQKQSLQPV PLQATMSAAT GIQPSPVNVV GVTSALGQQP SISSLAQPQL
PYSQAAPPVQ TPLPGAPPPQ QLQYGQQQPM VSTQMAPGHV KSVTQNAASE YVQQQPILQT
AMSSGQPSSA GVGAGTTVIP VAQPQSIQLP VQPTAVPAQP AGASVQPVGQ AQAAVSAVPT
GSQIANIGQQ ANIPTAVQQP STQVPPSVIQ QGAPPSSQVV PPAQTGIIHQ GVQTSAASLP
QQLVIASQST LLTVPPQPQG VEPVAQGVVS QQLPAVSPLP SASSISVTSQ VSSTGPSGMP
SAPANLVPPQ NIAQTPATQN GNLVQSVSQS PLIATNINLP LAQQIPLSST QFSAQSLAQA
IGSQIEDARR PAEPSLVGLP QTISGDSGGM SAVSDGSSSS LAASASLFPL KVLPLTTPLV
DGEDESSSGA SVVAIDNKIE QAMDLVKSHL MYAVREEVEV LKEQIKELIE KNSQLEQENN
LLKTLASPEQ LAQFQAQLQT GSPPATTQPQ GTTQPPAQPA SQGSGPTA
//
