ID A0A2K5KU89_CERAT Unreviewed; 1269 AA.
AC A0A2K5KU89;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE SubName: Full=NPC intracellular cholesterol transporter 1 {ECO:0000313|Ensembl:ENSCATP00000004259.1};
GN Name=NPC1 {ECO:0000313|Ensembl:ENSCATP00000004259.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000004259.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000004259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the patched family.
CC {ECO:0000256|ARBA:ARBA00005585}.
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DR AlphaFoldDB; A0A2K5KU89; -.
DR Ensembl; ENSCATT00000017341.1; ENSCATP00000004259.1; ENSCATG00000014820.1.
DR GeneTree; ENSGT00940000156182; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000014820; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0030301; P:cholesterol transport; IEA:UniProt.
DR Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR InterPro; IPR004765; NPC1-like.
DR InterPro; IPR032190; NPC1_N.
DR InterPro; IPR003392; Ptc/Disp.
DR InterPro; IPR000731; SSD.
DR NCBIfam; TIGR00917; 2A060601; 1.
DR PANTHER; PTHR45727; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR PANTHER; PTHR45727:SF2; NPC INTRACELLULAR CHOLESTEROL TRANSPORTER 1; 1.
DR Pfam; PF16414; NPC1_N; 1.
DR Pfam; PF02460; Patched; 1.
DR Pfam; PF12349; Sterol-sensing; 1.
DR SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR PROSITE; PS50156; SSD; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 259..285
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 343..363
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 613..634
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 646..670
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 676..698
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 719..740
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 752..777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1090..1108
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1115..1136
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1142..1160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1181..1207
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1219..1242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 612..777
FT /note="SSD"
FT /evidence="ECO:0000259|PROSITE:PS50156"
SQ SEQUENCE 1269 AA; 141277 MW; F5DD8C0C8C1D0A89 CRC64;
MLERGEGKGV AVFSQSCVWY GECGIAYGDK RYNCEYFGPP KPLPKDGYDL VQELCPGFFF
GNVSLCCDVQ QLQTLKDNLQ LPLQFLSRCP SCFYNLLNLF CELTCSPRQS QFLNVTATED
YVDPVTNQTK TNVKELQYFV GQSFANAMYN ACRDVEAPSS NDKALGLLCG KDADACNATN
WIEYMFNKDN GQAPFTITPV FSDFPVHGME PMNNATKGCD ESVDEVTAPC SCQDCSIVCG
PKPQPPPPPA PWTILGLDAM YVIMWITYMA FLLVFFGAFF AVWCYRKRYF VSEYTPIDSN
IAFSVNASDK GEASCCDPVS AAFEGCLRRL FTRWGSFCVR NPGCVIFFSL VFIAVCSSGL
VFVRVTTNPI DLWSAPSSQA RLEKEYFDQH FGPFFRTEQL IIRAPLTDKH TYQPYPSGAD
VPFGPPLDIQ ILHQVLDLQI AIENITASYN NETVTLQDIC LAPLSPYNTN CTIMSVLNYF
QNSHSVLDHK KGDDFFVYAD YHTHFLYCVR APASLNDTSL LHDPCLGTFG GPVFPWLVLG
GYDDQNYNNA TALVITFPVN NYYNDTEKLQ RAQAWEKEFI NLVRNYKNPN LTISFSAERS
IEDELNRESD SDIFTVVISY AIMFLYISLA LGHIKSCRRL LVDSKISLGI AGILIVLSSV
ACSLGIFSYI GLPLTLIVIE VIPFLVLAVG VDNIFILVQA YQRDERLQGE TLDQQLGRVL
GEVAPSMFLS SFSETVAFFL GAMSVMPAVH TFSLFAGLAV FIDFLLQITC FVSLLGLDIN
RQEKNRLDIF CCVRGAEDGT SVQASESCLF RFFKNSYSPL LLKDWMRPIV IAIFVGVLSF
SIAVLNKVDI GLDQFLSMPD DSYVVDYFKS MSQYLHAGPP VYFVLEEGHD YTSPKGQNMV
CGGMGCNNDS LVQQIFNAAQ LDNYTRIGFA PSSWIDDYFD WVKPQSSCCR VDNITDQFCN
ASVVDPACVR CRPLTPEGKQ RPQGGDFMRF LPMFLSDNPN PKCGKGGHAA YSSAVNILGN
GTRVGATYFM TYHTVLQTSA DFIDALKKAR LIASNVTETM GINGSAYRVF PYSVFYVFYE
QYLTIIDDTI FNLGVSLGAI FLVTMVLLGC ELWSAVIMCA TIAMVLVNMF GVMWLWGISL
NAVSLVNLVM SCGISVEFCS HITRAFTVST KGSRVERAEE ALAHMGSSVF SGITLTKFGG
IVVLAFAKSQ IFQIFYFRMY LAMVLLGATH GLIFLPVLLS YIGPSVNKAK SCATEERYKG
TERERLLNF
//
