ID A0A2K5KV28_CERAT Unreviewed; 992 AA.
AC A0A2K5KV28;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=Sorting nexin 19 {ECO:0000313|Ensembl:ENSCATP00000004543.1};
GN Name=SNX19 {ECO:0000313|Ensembl:ENSCATP00000004543.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000004543.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000004543.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR RefSeq; XP_011908816.1; XM_012053426.1.
DR AlphaFoldDB; A0A2K5KV28; -.
DR STRING; 9531.ENSCATP00000004543; -.
DR Ensembl; ENSCATT00000018008.1; ENSCATP00000004543.1; ENSCATG00000015689.1.
DR GeneID; 105582665; -.
DR KEGG; caty:105582665; -.
DR CTD; 399979; -.
DR GeneTree; ENSGT00950000182856; -.
DR OrthoDB; 2919310at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000015689; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0002062; P:chondrocyte differentiation; IEA:Ensembl.
DR GO; GO:1990502; P:dense core granule maturation; IEA:Ensembl.
DR GO; GO:0051649; P:establishment of localization in cell; IEA:Ensembl.
DR GO; GO:0030073; P:insulin secretion; IEA:Ensembl.
DR CDD; cd06893; PX_SNX19; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR001683; PX_dom.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR037909; SNX19_PX.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR PANTHER; PTHR22775:SF31; SORTING NEXIN-19; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF00787; PX; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00312; PX; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS50195; PX; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 29..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..272
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT DOMAIN 533..663
FT /note="PX"
FT /evidence="ECO:0000259|PROSITE:PS50195"
FT REGION 411..438
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..726
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 769..818
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 973..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..723
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..818
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 108699 MW; 525D3DD961A20E4F CRC64;
MKTETVPPFQ ETAAGSSCHL SNLLSSRKLM AVGVLLGWLL VVHLLVNVWL LCLLSASLVV
LGGWLGSSVA GAASGRLHLE RFIPLATCPP CPEAERQLEQ EINRTIQMII RDFVLSWYRS
VSQEPAFEEE MEAAMKGLVQ ELRRRMSMMD CHALAQSVLI LCRCHLQSYI QAKEATAGKN
GPAEPSHLWE AYCRATAPHP AVHSSSAEVT YTRGVVNLLL QGLVPKPHLE TRTGRHVVVE
LITCNVILPL ISRLSDPDWI HLVLVGIFSK ARDPAPCPAS APEQPSVPTS LPLIAEVEQL
PEGRTSPVAA PVFLSYSEPE GPAGPSPEVE EGHEAVEGDL GGMCEERKVG NNSSHFLQPN
LRGPLFLCED SELESPLSEL GKETIMLMTP GNFLSDRIQD ALCALEGSQA LEPKDGEASE
GAEAEEGPGT ETETGLPVST LNSYPEIQID TADKEIEQGD VTTSVTALLE GPEKTCPSRP
SCLEKDLTHD MSSLDPTLPP VLLSSSPPGP LSSTTFSFEP LSSPDGPVTI QNLRITGTIT
AREHSGTGFH PYTLYTVKYE TALDGENSSG LQQLAYHTVN RRYREFLNLQ TRLEEKPDLR
KFIKNVKGPK KLFPDLPFGN MDSDRVEARK SLLESFLKQL CAIPEIANSE EVQEFLALNT
DARISFVKKQ FMVSRIDKMV VSAIVDTLKT AFPRSEPQSP TEELSEAETE SKSQTEGKKA
GKSRLRFSSS KISPALSVTE AQDKILYCLQ EGNVESETLS MSGMESFVEK QTKSLEMQPT
KAPEKDPEQP PKGHVDSCLS DAAVPAQDPS NSDPGTETAL ADTALDLLLL LLTEQWKWLC
TENMQKFLRL IFGTLVQRWL EVQVANLTSP QRWVQYLRLL QESIWPGGVL PKFPRPVRTQ
EQKLAAEKQA LQSLMGVLPD LVVEILGVNK CQVSWGLVLE SLQQPLINRH LIYCLGDIIL
EFLDLSASVE KSAATTSASD TPGNSKRMGV SS
//
