ID A0A2K5L1I2_CERAT Unreviewed; 4428 AA.
AC A0A2K5L1I2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=FAT atypical cadherin 4 {ECO:0000313|Ensembl:ENSCATP00000006800.1};
GN Name=FAT4 {ECO:0000313|Ensembl:ENSCATP00000006800.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000006800.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000006800.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSCATT00000024147.1; ENSCATP00000006800.1; ENSCATG00000020876.1.
DR GeneTree; ENSGT00940000155719; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000020876; Expressed in colon and 12 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 33.
DR CDD; cd00054; EGF_CA; 4.
DR CDD; cd00110; LamG; 2.
DR Gene3D; 2.60.120.200; -; 2.
DR Gene3D; 2.60.40.60; Cadherins; 34.
DR Gene3D; 2.10.25.10; Laminin; 5.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR001791; Laminin_G.
DR PANTHER; PTHR24025; DESMOGLEIN FAMILY MEMBER; 1.
DR PANTHER; PTHR24025:SF17; FAT ATYPICAL CADHERIN 4; 1.
DR Pfam; PF00028; Cadherin; 32.
DR Pfam; PF00008; EGF; 2.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 2.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 33.
DR SMART; SM00181; EGF; 5.
DR SMART; SM00179; EGF_CA; 4.
DR SMART; SM00282; LamG; 2.
DR SUPFAM; SSF49313; Cadherin-like; 33.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00232; CADHERIN_1; 19.
DR PROSITE; PS50268; CADHERIN_2; 34.
DR PROSITE; PS00022; EGF_1; 6.
DR PROSITE; PS01186; EGF_2; 3.
DR PROSITE; PS50026; EGF_3; 5.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS50025; LAM_G_DOMAIN; 2.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..38
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 39..4428
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014381454"
FT DOMAIN 43..135
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 136..250
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 251..353
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 359..475
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 476..582
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 584..689
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 690..793
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 794..893
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 894..996
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 997..1100
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1101..1210
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1211..1315
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1316..1420
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1428..1529
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1544..1629
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1630..1740
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1741..1841
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1842..1944
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 1945..2051
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2051..2154
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2155..2259
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2260..2364
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2365..2468
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2469..2569
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2570..2671
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2672..2775
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2775..2874
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2875..2985
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 2986..3018
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3019..3123
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3124..3227
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3228..3333
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3334..3439
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3438..3549
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 3731..3789
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3791..3827
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3829..3865
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3867..3903
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 3904..4088
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 4091..4127
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 4146..4327
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DISULFID 3779..3788
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3817..3826
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3855..3864
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 3893..3902
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 4117..4126
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 4428 AA; 482050 MW; C299B24271211051 CRC64;
MDLAPDRATG RPWLPLHTLS VSQLLRVFWL LSLLPGQAWV HGAEQRQVFQ VLEEQPPGTL
VGTIQTRPGF TYRLSESHAL FAINSSTGAL YTTSTIDRES LPSDVINLVV LSSAPTYPTE
VRVLVRDLND NAPVFPDPSI VVTFKEDSSS GRQVILDTAT DSDIGSNGVD HRSYRIIRGN
EAGRFRLDIT LNPSGEGAFL HLVSKGGLDR EVTPQYQLLV EVEDKGEPKR RGYLQVNVTV
QDINDNPPVF GSSHYQAGVP EDAVVGSSVL QVAAADADEG TNADIRYRLQ DEGTPFQMDP
ETGLITVREP LDFEARRQYS LTVQAMDRGV PSLTGRAEAL IQLLDVNDND PVVKFRYFPA
TSRYASVDEN AQVGTVVALL TVTDADSSAA NGNISVQILG GNEQRHFEVQ SSKVPNLSLI
KVASALDRER IPSYNLTVSV SDNYGAPPGA AVQARSSVAS LVIFVNDIND HPPVFSQQVY
RVNLSEEAPP GSYVSGISAT DGDSGLNANL RYSIVSGNGL GWFHISEHSG LVTTGAAGGL
DRELASQIVL NISARDQGVH PKVSYAQLVV TLLDVNDEKP VFSQPEGYDV SVVENAPTGT
ELLMLRATDG DLGDNGTVRF SLQEAETDRR SFRLDPVSGR LSTISSLDRE DQAFYSLLVL
ATDLGSPPQS SMTRINVSLL DINDNSPVFY PVQYFAHIKE NEPGGSYITT VSATDPDLGS
NGTVKYSISA GDRSRFQVNA QSGVISTRMA LDREEKTAYQ LQIVATDGGN LQSPNQAIVT
ITVLDTQDNP PVFSQVAYSF VVFENVALGY HVGSVSASTM DLNCNISYLI TTGDQKGMFA
INQVTGQLTT ANVIDREEQS FYQLKVVASG GTVTGDTMVN ITVKDLNDNS PHFLQAIESV
NVVENWQAGH SIFQAKAVDP DEGVNGIVLY SLKQNPKNLF AVNEKNGTIS LLGPLDVQAG
SYQIEILASD MGVPQLSSSV ILTVYVHDVN DNSPVFDQLS YEVTLSESEP VNSRFFKVQA
SDKDSGANGE IAYTIAEGNT GDAFGIFPDG QLYIKSELDR ELQDRYVLMV VASDRAVEPL
SATVNVTVIL EDVNDNRPLF NSTNYTFYFE EEQRAGSFVG KVSAVDKDFG PNGEVRYSFE
MVQPDFELHT ISGEITNTYQ FDRESLMRRR GTAVFSFTVI ATDQGLPQPL KDQATVHVYM
KDINDNAPKF LKDFYQATIS ESAANLTQVL RVSASDVDEG NNGLIHYSII KGNEERQFAI
DITSGQVALI GKLDYEATPA YSLVIQAVDS GTIPLNSTCT LNIDILDEND NTPSFPKSTL
FVDVLENMRI GELVSSVTAT DSDSGDNADL YYSITGTNNH GTFSISPNTG SIFLAKKLDF
ETQSLYKLNI TAKDQGRPPR SSTMSVVIHV RDFNDNPPSF PPGDIFKSIV ENIPIGTSVI
SVTAHDPDAD INGQLSYTII QQMPRGNHFT IDEVKGTIYT NAEIDREFAN LFELTIKAND
QAVPIETRRY ALKNVTILVT DLNDNVPMFI SQNALAADPS AVIGSVLTTI MAADPDEGAN
GEVEYEIING DTDTFIVDRY SGDLRVASAL VPSQLIYNLI VSATDLGPER RKSTTELTII
LQGLDGPVFT QPKYITILKE GEPIGTNVIS IEAASPRGSE APVEYYIVSV RCEEKTVGRL
FTIGRHTGII QTAAILDREQ GACLYLVDVY AIEKSTAFPR TQRAEVEITL QDINDNPPVF
PTDMLDLTVE ENIGDGSKIM QLTAMDADEG ANALVTYTII SGADDSFRID PESGDLIATR
RLDRERRSKY SLLVRADDGL QSSDMRINIT VSDVNDHTPK FSRPVYSFDI PEDTIPGSLV
AAILATDDDS GVNGEITYIV NEDDEDGIFF LNPITGVFNL TRVLDYEVQQ YYILTVRAED
GGGQFTAIRV YFNILDVNDN PPIFSLNSYS TSLMENLPVG STVLVFNVTD ADDGINSQLA
YSIASGDSLG QFTVDKNGVL KVLKALDRES QSFYNLVVQV HDLSQIPASR FTSTAQVSII
LLDVNDNPPT FLSPKLTYIP ENTPIDTVVF KAQASDPDSG PNSYIEYTLL NPLGNKFSIG
TIDGEVRLTG ELDREEVSNY TLTVVATDKG QPSLSSSTEV IVMVLDINDN NPIFAQTLYK
VEINENTLTG TDIIQVFAAD GDEGTNGQVR YGIVNGNTNQ EFRIDSVTGA ITVAKPLDRE
KTPTYHLTVQ AADRGSTPRT DTSTVSIVLL DINDFVPVFE LSPYSVNVPE NLRTLPRTIL
QVVARDDDQG SNSKLSYVLF GGNEDNAFTL SASGELGVTQ SLDRETKEQF VLMITAIDGG
SPALTGTGTI SVIVDDVNDN VPTFASKAYF TTIPEDAPTG TDVLLVNASD ADASTNAVVS
YRIIGGNSQF TINPSTGQII TSALLDRETK DNYTLVVVCS DAGYPEPLSS STSVLVTVTD
VNDNPPRFQH HPYVTHIPSP TLPGSFVFAV TVTDADIGPN SELHYSLSGR NSEKFHIDPL
RGAIMAAGPL NGASEVTFSV HVKDGGSFPK TDSTTVTVRF VNKADFPKVR AKEQTFMFPE
NQPVSSLVTT IAGSSLRGEP MSYYIASGNL GNTFQIDQLT GQVSISQPLD FEKIQKYVVW
IEARDGGFPP FSSYEKLDIT VLDVNDNAPI FKEDPFVSEI LENLSPRKIL TVSAVDKDSG
PNGQLDYEIV NGNMENSFSI NHATGEIRSV RPLDREKVSY YVLTIKSSDK GSPSQSTSVK
VMINILDEND NAPRFSQIFS AHVPENSPLG YTVTRVTTSD EDIGINAISR YSIMDTSLPF
TINPSTGDIV ISRPLNREDT DRYRIRVSAH DSGWTVSTDV TIFVTDVNDN APRFGRPSYY
LDCPELTEIG SKVTQVFATD PDEGSNGQVF YFIKSQSEYF RINATTGEIF NKQILKYQNV
TGFSNVNINR HSFIVTSSDR GNPSLISETT VTINIVDSND NAPQFLKITA KDKGNPPLSS
QATVEIIVTE ENYHTPEFSQ SHMSATIPES HSVGSIVRTV SARDRDAAMN GLIKYSISSG
NEEGIFAINS STGILTLAKA LDYELCQKHE MTISAIDGGW VARTGYCSVT VNVIDVNDNS
PVFLSDDYFP TVLENAPSGT TVIHLNATDA DSGTNAVIAY TVQSSDSDLF VIDPNTGVIT
TQGFLDFETK QSYHLTVKAF NVPDEERCSF ATVNVQLKGT NEYVPRFVSK LYYFEISEAA
PKGTIVGEVF ASDRDLGTDG EVHYLIFGNS RKKGFQINKK TGQIYVSGIL DREKEERVSL
KVLAKNFGSI RGADIDEVTV NVTVLDANDP PVFTLNIYSV QISEGVPIGT HVTFVSAFDS
DSIPSWSRFS YFIGSGNENG AFSINPQTGQ ITVTAELDRE TLPIYNLSVL AVDSGTPSAT
GSASLLVTLE DINDNGPMLT VSEGEVMENK RPGTLVMTLQ STDPDLPPNQ GPFTYYLLST
GPATNYFSLS TVGVLSTTRE IDREQIADFY LSVVTKDSGV PQMSSTGTVH ITVIDQNDNP
SQSRTVEIFV NYYGNLFPGG ILGSVKPQDP DVLDSFHCSL TSGVTSLFSI PGGTCDLNSQ
PRSTDGTFDL TVLSNDGVHS TVTSNIRVFF AGFSNATVDN SILLRLGIPT VKDFLTNHYL
HFLRIASSQL TGLGTAVQLY SAYEENNRTF LLAAVKRNHN QYVNPSGVAT FFESIKEILF
RQSGVKVESV DHDSCVHGPC QNGGSCLRRL AVSSVLKSRE SLPVIIVANE PLQPFLCKCL
PGYAGSWCEI DIDECLPSPC HNGGTCHNLV GGFSCSCPDG FTGRACERDI NECLQSPCKN
GAVCQNFPGS FNCVCKTGYT GKMCESSVNY CECNPCFNGG SCQSGVDSYY CHCPFGVFGK
HCELNSYGFE ELSYMEFPSL DPNNNYIYVK FATIKSHALL LYNYDNQTGD RAEFLALEIA
EERLRFSYNL GSGTYKLTTM KKVSDGHFHT VIARRAGMAA SLTVDSCSEN QEPGYCTVSN
VAVSDDWTLD VQPNRVTVGG IRSLEPILQR RGHVESHDFV GCIMEFAVNG RPLEPSQALA
AQGILDQCPR LEGACTRSPC QHGGTCMDYW SWQQCHCKEG LTGKYCEKSL TPDTALSLEG
KGRLDYHMSQ NEKREYLLRQ SIRGAMLEPF GVNSLEVKFR TRSENGILIH IQESSNYTTV
KIKNGKVHFT SDAGIAGKVE RNIPEVYVAD GHWHTFLIGK NGTATVLSVD RIYNRDIIHP
TQDFGGLDVL TISLGGIPPN QAHRDAQTAG FDGCIASMWY GGESLPFSGK HSLASISKTD
PSVKIGCRGP NICASNPCWG DLLCINQWYA YRCVPPGDCA SHPCQNGGSC EPGLHRPCTL
ASPGSCPDST HRKDPVRWWC LSWRPLSSGK CAKAGSPAGI VCVLSPGP
//
