ID A0A2K5L279_CERAT Unreviewed; 731 AA.
AC A0A2K5L279;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Zinc finger protein 493 {ECO:0000313|Ensembl:ENSCATP00000007051.1};
GN Name=ZNF493 {ECO:0000313|Ensembl:ENSCATP00000007051.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000007051.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000007051.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000256|ARBA:ARBA00006991}.
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DR AlphaFoldDB; A0A2K5L279; -.
DR Ensembl; ENSCATT00000024734.1; ENSCATP00000007051.1; ENSCATG00000021321.1.
DR GeneTree; ENSGT00940000161765; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000021321; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd07765; KRAB_A-box; 1.
DR Gene3D; 6.10.140.140; -; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 19.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR24393; ZINC FINGER PROTEIN; 1.
DR PANTHER; PTHR24393:SF62; ZINC FINGER PROTEIN 680; 1.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 17.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 10.
DR SUPFAM; SSF109640; KRAB domain (Kruppel-associated box); 1.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 17.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00042}.
FT DOMAIN 14..96
FT /note="KRAB"
FT /evidence="ECO:0000259|PROSITE:PS50805"
FT DOMAIN 194..221
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 222..249
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 250..277
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 278..305
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 306..333
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 334..361
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 362..389
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 390..417
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 418..445
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 446..473
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 474..501
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 502..529
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 530..557
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 558..585
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 586..613
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 614..641
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 642..669
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 670..697
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 698..725
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
SQ SEQUENCE 731 AA; 85142 MW; A82E412BC375CE0E CRC64;
QPPPPEFKQF SGPLTFRDVA IEFSLEEWQC LDSAQQDLYR KVMLENYRNL RIRARFMLFI
FNKAGIDVSK PNLITCLEQG KDPWNMKRHS MVVKPPVICS HFAEDLCPGP GIKDSFQKVI
LREYVKCGHK DLQLKKGCKS VNECNVHKEG YNELNLCLTT TQRKIFPCDK YVKVFHKFLN
SNRHNTKHTR KKPFKCKKCG KSFCLLLHLH QHKRIHIREN SYQCEECGKA FIWFSTLTRH
RRVHTGKKSY KYEECGKAFN QDSNLSTHKR IHTRQKSYKC EECGTAFYQF SHLTRHKLIH
TGEKPYKCEE CGKAFNRSST LTRHKIIHTG EKPYKCEECG KAFSVFSTLT KHKIIHTEEK
PHRCEEYGKV YKESSHLTTH KRINTGEKPY KCEECGKTFS IFSILTKHKI IHTEEKPYKC
EECGKAFKRS STLTNHKIIH TEEKPYKCEE CGKAFKQSST LTIHKIIHTG EKPYKCEECG
KAFKRSSTFT IHKIIHTGEK PYKCEECGKA FNRSSHLTTH KRIHTGQKPY KCKECGKSFS
EFSTLTKHKI IHTEEKPYKC EECGKAFNRS SILSIHKKTH TGEKPYKCEE CGKAFKQSSH
LAGHKHVHGG QKPYKCESCG KAFSIFSTLT KHKIIHTEEK PYKCEECGKT FYRFSNLNTH
KIIHTGKKPC KCEECGKAFN HSSNLTKHKL IHTGDKPYKC EQCGKAFRRS SHLSRHKIIH
IGIHTEEILQ M
//
