ID A0A2K5L3K8_CERAT Unreviewed; 1064 AA.
AC A0A2K5L3K8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE SubName: Full=Integrin subunit alpha 3 {ECO:0000313|Ensembl:ENSCATP00000007523.1};
GN Name=ITGA3 {ECO:0000313|Ensembl:ENSCATP00000007523.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000007523.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000007523.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR RefSeq; XP_011901586.1; XM_012046196.1.
DR AlphaFoldDB; A0A2K5L3K8; -.
DR STRING; 9531.ENSCATP00000007523; -.
DR Ensembl; ENSCATT00000025942.1; ENSCATP00000007523.1; ENSCATG00000022073.1.
DR GeneID; 105579450; -.
DR CTD; 3675; -.
DR GeneTree; ENSGT00940000157746; -.
DR OrthoDB; 3816176at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000022073; Expressed in lung and 9 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:Ensembl.
DR GO; GO:0060076; C:excitatory synapse; IEA:Ensembl.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0031527; C:filopodium membrane; IEA:Ensembl.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0034667; C:integrin alpha3-beta1 complex; IEA:Ensembl.
DR GO; GO:0031594; C:neuromuscular junction; IEA:Ensembl.
DR GO; GO:0048787; C:presynaptic active zone membrane; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0002020; F:protease binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:Ensembl.
DR GO; GO:0097062; P:dendritic spine maintenance; IEA:Ensembl.
DR GO; GO:0035640; P:exploration behavior; IEA:Ensembl.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0030324; P:lung development; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0048333; P:mesodermal cell differentiation; IEA:Ensembl.
DR GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0072006; P:nephron development; IEA:Ensembl.
DR GO; GO:0001764; P:neuron migration; IEA:Ensembl.
DR GO; GO:1903078; P:positive regulation of protein localization to plasma membrane; IEA:Ensembl.
DR GO; GO:0030510; P:regulation of BMP signaling pathway; IEA:Ensembl.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0030111; P:regulation of Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0097205; P:renal filtration; IEA:Ensembl.
DR GO; GO:0007266; P:Rho protein signal transduction; IEA:Ensembl.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0099560; P:synaptic membrane adhesion; IEA:Ensembl.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF89; INTEGRIN ALPHA-3; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR PRINTS; PR01185; INTEGRINA.
DR SMART; SM00191; Int_alpha; 5.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR PROSITE; PS51470; FG_GAP; 5.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 31..1064
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5014209025"
FT TRANSMEM 990..1012
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 36..101
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 234..290
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 291..352
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 354..409
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 413..475
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 460..612
FT /note="Integrin alpha first immunoglubulin-like"
FT /evidence="ECO:0000259|Pfam:PF08441"
FT DOMAIN 613..752
FT /note="Integrin alpha second immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20805"
FT DOMAIN 761..977
FT /note="Integrin alpha third immunoglobulin-like"
FT /evidence="ECO:0000259|Pfam:PF20806"
FT REGION 853..887
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1064 AA; 118355 MW; C8AF2642C26803FD CRC64;
MGPGPSCAPR APRLMLCALM VAAGGCVVSA FNLDTRFLVV KEAGNPGSLF GYSVALHRQT
ERQQRYLLLA GAPRELAVPD GYTNRTGAVY LCPLTAHKDD CERMNITVKS DPGHHIIEDM
WLGVTVASQG PAGRVLVCAH RYTQVLWSGS EDQRRMVGKC YVRGNDLELD PSDDWQTYHN
EMCNSNTDYL ETGMCQLGTS GGFTQNTVYF GAPGAYNWKG NSYMIQRKEW DLSEYSYKDP
EDQGNLYIGY TVQVGSAILH PKNITIVTGA PRHRHMGAVF LLSQEAGGDL RRRQVLEGSQ
VGAYFGSAIA LADLNNDGWQ DLLVGAPYYF ERKEEVGGAV YVFMNQAGTS FPAHPSLLLH
GPSGSAFGLS VASIGDINQD GFQDIAVGAP FEGLGKVYIY HSSSKGLPRQ PQQVIHGEKL
GLPGLATFGY SLSGQMDVDE NFYPDLLVGS LSDHIVLLRA RPVINIVHKT LVARPAVLDP
ALCTATSCVQ VELCFAYNQS AGNPNYRRNI TLAYTLEADR DRRPPRLRFA GSESAVFHGF
FSMPEMRCQK LELLLMDNLR DKLRPIIISM NYSLPLRMPD RPRLGLRSLD AYPILNQAQA
LENHTEVQFQ KECGPDNKCE SNLQMRAAFV SEQQQKLSRL QYSRDVRKLL LSINVTNTRT
SEHTGEDAHE ALLTLVVPPA LLLSSVRPPG ACQANETIFC ELGNPFKRNQ RMELLIAFEV
IGVTLHTRDL QVQLQLSTSS HQDNLWPMTL TLLVDYTLQT SLSMVNHRLQ SFFGGTVMGE
SGMKTVEDVG SPLKYEFQVG PMGEGLVGLG TLVLGLEWPY EVSNGKWLLY PTEITIHGNG
SWPCQPPGDL VNPLNLTLSD PGDRLSSPQR RRRQLDPGGG QGPPPVTLAA AKKAKSETVL
TCATGRARCV WLECPIPDAP VVTNVTVKAR VWNSTFIEDY RDFDRVRVNG WATLFLRTSI
PTINMENKTT WFSVDIDSEL VEELPAEIEL WLVLVAVGAG LLLLGLIILL LWKCDFFKRT
RYYQIMPKYH AVRIREEERY PPPGSTLPTK KHWVTSWQTR DRYY
//
