ID A0A2K5L5Q0_CERAT Unreviewed; 717 AA.
AC A0A2K5L5Q0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Solute carrier organic anion transporter family member {ECO:0000256|RuleBase:RU362056};
GN Name=SLCO6A1 {ECO:0000313|Ensembl:ENSCATP00000008259.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000008259.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000008259.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362056};
CC Multi-pass membrane protein {ECO:0000256|RuleBase:RU362056}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
CC {ECO:0000256|ARBA:ARBA00009657, ECO:0000256|RuleBase:RU362056}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU362056}.
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DR AlphaFoldDB; A0A2K5L5Q0; -.
DR STRING; 9531.ENSCATP00000008259; -.
DR Ensembl; ENSCATT00000028701.1; ENSCATP00000008259.1; ENSCATG00000024448.1.
DR GeneTree; ENSGT01080000257410; -.
DR OMA; LMRFVIV; -.
DR Proteomes; UP000233060; Unplaced.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006811; P:monoatomic ion transport; IEA:UniProtKB-KW.
DR GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 2.
DR InterPro; IPR002350; Kazal_dom.
DR InterPro; IPR036058; Kazal_dom_sf.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR004156; OATP.
DR NCBIfam; TIGR00805; oat; 1.
DR PANTHER; PTHR11388; ORGANIC ANION TRANSPORTER; 1.
DR PANTHER; PTHR11388:SF95; SOLUTE CARRIER ORGANIC ANION TRANSPORTER FAMILY MEMBER 6A1; 1.
DR Pfam; PF07648; Kazal_2; 1.
DR Pfam; PF03137; OATP; 1.
DR SUPFAM; SSF100895; Kazal-type serine protease inhibitors; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS51465; KAZAL_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|RuleBase:RU362056};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362056};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362056};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362056}; Transport {ECO:0000256|RuleBase:RU362056}.
FT TRANSMEM 109..133
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 145..165
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 171..193
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 228..248
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 314..335
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 423..447
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 453..475
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 578..603
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 609..627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT TRANSMEM 666..691
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362056"
FT DOMAIN 496..551
FT /note="Kazal-like"
FT /evidence="ECO:0000259|PROSITE:PS51465"
FT REGION 1..43
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 717 AA; 79453 MW; 11DDEEE77A7486EE CRC64;
MPENVARRSE DQYEVPGRVE PREAARARPP KDWRSSKSSN SSKFGKKYRY LKLLPEALVR
FGGFRKRKKD KSSVSKKPGE LDDSSEQPCG LGCLVSPCCE CCNNIRCFMV FYCILVLCQG
VVFGLTDVSI GNVQREYSLK TIEKLALELS YDISSGLVAM FIAFYGDRKK VTWFVASSFL
IGLGSLLCAL PFINEEKNKS KVGIEDICTE TKVVSGCQSS DASFQSKYLY FITLGQTMQG
IAGMPLYILG TTFIDENVAT HSAGIYVGIA ECTSMIGYGM GYVIGAPLVK VPENSTSATN
TTGTNGSTEW LWTWWIRFLS TTLVAWFTLI PLSCFPHNMP GSTRIKAAKH KQLHWFDSKL
KDLQVGTSIK DLCAVFWILM KNPVLICLSL SKATEYLVII GAAEFLPIYL ENQFMLTPPV
ATILAGLVLI PGGALGQLLG GIIASTLEMS CKALMRFIMA TSVISLILLM FITFVRCNPL
QFAGINEDYD GEGQVGNLTA PCNEKCRCSS SVYSSICGRD DIEYFSPCFA GCMYSKALTR
EKTYYNCSCI KEGLITADAE GDFIDARRGK CDAKCYKLPL FVAFIFSTLV FSGFSGVPIV
LAIMRIVPVQ LRSLALGVCY VVLRIFGTIP GPSIFKMSGE NSCIFRDVNE CGHTGRCWIY
NKTRMAYLLV GISFLCKLCT IIFTTTAFFM YKRQVNESTD IPNITVKNPK VKKKRRN
//
