ID A0A2K5L604_CERAT Unreviewed; 740 AA.
AC A0A2K5L604;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 27.
DE RecName: Full=Myotubularin-related protein 12 {ECO:0000256|ARBA:ARBA00018495};
DE AltName: Full=Inactive phosphatidylinositol 3-phosphatase 12 {ECO:0000256|ARBA:ARBA00033343};
GN Name=MTMR12 {ECO:0000313|Ensembl:ENSCATP00000008364.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000008364.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000008364.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere
CC {ECO:0000256|ARBA:ARBA00004204}. Sarcoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004369}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR AlphaFoldDB; A0A2K5L604; -.
DR Ensembl; ENSCATT00000029109.1; ENSCATP00000008364.1; ENSCATG00000023509.1.
DR GeneTree; ENSGT00940000160263; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000023509; Expressed in spleen and 12 other cell types or tissues.
DR CDD; cd14594; PTP-MTMR12; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR030576; MTMR12_PTP.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF37; MYOTUBULARIN-RELATED PROTEIN 12; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Sarcoplasmic reticulum {ECO:0000256|ARBA:ARBA00022951}.
FT DOMAIN 198..636
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
SQ SEQUENCE 740 AA; 85605 MW; C3E6E3486CF6A464 CRC64;
MQSGSAAQSG VQWRDLGSLQ EIHTNEKEVT EKEVTLHLLP GEQLLCEAST VLKYVQEDSC
QHGVYGRLVC TDFKIAFLGD DESALDSDET QFKNKVVGEN DITLHCVDQI YGVFDEKKKT
LFGQLKKYPE KLIIHCKDLR VFQFCLRYTK EEEVKRIVSG IIHHTQAPKL LKRLFLFSYA
TAAQNNTVTD PKNHTIMFDT LKDWCWELER TKGNMKYKAV SVNEGYKVCE RLPAYFVVPT
PLPEENVQRF QGHGIPIWCW SCHNGSALLK MSALPKEQDD GILQIQKSFL DGVYKTIHRP
PYEIVKTEDL SSNFLSLQEI QTAYSKFKQL FLIDNSTEFW DTDIKWFSLL ESSSWLDIIR
RCLKKAIEIT ECMEAQNMNV LLLEENASDL CCLISSLVQL MMDPHCRTRI GFQSLIQKEW
VMGGHCFLDR CNHLRQNDKE EVPVFLLFLD CVWQLVHQHP PAFEFTETYL TVLSDSLYIP
IFSTFFFNSP HQKDTNMGRE GQDTQSKPLN LLTVWDWSVQ FEPKAQTLLK NPLYVEKPKL
DKGQRKGMRF KHQRQLSLPL TQSKSSPKRG FFREETDHLI KNLLGKRISK LINSSDELQD
NFREFYDSWH SKPTDYHGLL LPHIEGPEIK VWAQRYLRWI PEAQILGGSR VATMSKLLEM
IEEVQSLQEK IDERHHSQQA PQAEAPCLLR NSARLSSLFP FALLQRHSSK PVLPTSGWKA
LGDEDDLAKR EDEFVDLGDV
//