UniProt: A0A2K5L7C9

Database: UniProt
Entry: A0A2K5L7C9_CERAT

LinkDB:  A0A2K5L7C9_CERAT 
Original site:  A0A2K5L7C9_CERAT

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Ontology (5)   
   GO (5)   
Gene (5)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
Protein sequence (1)   
   RefSeq(pep) (1)   
Protein domain (2)   
   InterPro (1)   
   Pfam (1)   
All databases (13)   

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ID   A0A2K5L7C9_CERAT        Unreviewed;       210 AA.
AC   A0A2K5L7C9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 30.
DE   RecName: Full=Calcium-activated potassium channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE            Short=BKbeta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=BK channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Calcium-activated potassium channel, subfamily M subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Charybdotoxin receptor subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=K(VCA)beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Maxi K channel subunit beta {ECO:0000256|RuleBase:RU368097};
DE   AltName: Full=Slo-beta {ECO:0000256|RuleBase:RU368097};
GN   Name=KCNMB4 {ECO:0000313|Ensembl:ENSCATP00000008847.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000008847.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000008847.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- FUNCTION: Regulatory subunit of the calcium activated potassium KCNMA1
CC       (maxiK) channel. Modulates the calcium sensitivity and gating kinetics
CC       of KCNMA1, thereby contributing to KCNMA1 channel diversity.
CC       {ECO:0000256|RuleBase:RU368097}.
CC   -!- SUBUNIT: Interacts with KCNMA1 tetramer. There are probably 4 molecules
CC       of KCMNB per KCNMA1 tetramer. {ECO:0000256|RuleBase:RU368097}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC       ECO:0000256|RuleBase:RU368097}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU368097}.
CC   -!- PTM: N-glycosylated. {ECO:0000256|RuleBase:RU368097}.
CC   -!- SIMILARITY: Belongs to the KCNMB (TC 8.A.14.1) family.
CC       {ECO:0000256|RuleBase:RU368097}.
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DR   RefSeq; XP_011905083.1; XM_012049693.1.
DR   AlphaFoldDB; A0A2K5L7C9; -.
DR   SMR; A0A2K5L7C9; -.
DR   STRING; 9531.ENSCATP00000008847; -.
DR   Ensembl; ENSCATT00000031090.1; ENSCATP00000008847.1; ENSCATG00000026892.1.
DR   GeneID; 105581021; -.
DR   KEGG; caty:105581021; -.
DR   CTD; 27345; -.
DR   GeneTree; ENSGT00950000183039; -.
DR   OMA; RGTAQYP; -.
DR   OrthoDB; 3976732at2759; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000026892; Expressed in frontal cortex and 9 other cell types or tissues.
DR   GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0015269; F:calcium-activated potassium channel activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0015459; F:potassium channel regulator activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005513; P:detection of calcium ion; IEA:UniProtKB-UniRule.
DR   GO; GO:0019228; P:neuronal action potential; IEA:Ensembl.
DR   InterPro; IPR003930; K_chnl_Ca-activ_BK_bsu.
DR   PANTHER; PTHR10258; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA; 1.
DR   PANTHER; PTHR10258:SF3; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT BETA-4; 1.
DR   Pfam; PF03185; CaKB; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|RuleBase:RU368097};
KW   Ion channel {ECO:0000256|RuleBase:RU368097};
KW   Ion transport {ECO:0000256|RuleBase:RU368097};
KW   Membrane {ECO:0000256|RuleBase:RU368097};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Transmembrane {ECO:0000256|RuleBase:RU368097};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU368097};
KW   Transport {ECO:0000256|RuleBase:RU368097}.
FT   TRANSMEM        20..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368097"
FT   TRANSMEM        174..198
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU368097"
SQ   SEQUENCE   210 AA;  23949 MW;  A59D56DD034F027A CRC64;
     MAKLRVAYEY TEAEDKSIRL GLFLIISGVV SLFIFGFCWL SPALQDLQAT EANCTVLSVQ
     QIGEVFECTF TCGADCRGTS QYPCVQVYVN NSESNSRALL HSDEHQLLTN PKCSYIPPCK
     RENQKNLESV MNWQQYWKDE IGSQPFTCYF NQHQRPDDVL LHRTHDEIVL LHCFLWPLVT
     FVVGVLIVVL TICAKSLAVK AEAMKKRKFS
//

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