ID A0A2K5L7V7_CERAT Unreviewed; 789 AA.
AC A0A2K5L7V7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Tubulin tyrosine ligase like 8 {ECO:0000313|Ensembl:ENSCATP00000009021.1};
GN Name=TTLL8 {ECO:0000313|Ensembl:ENSCATP00000009021.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000009021.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000009021.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + glycine + L-glutamyl-[protein] = ADP + glycyl-L-
CC glutamyl-[protein] + H(+) + phosphate; Xref=Rhea:RHEA:67180,
CC Rhea:RHEA-COMP:10208, Rhea:RHEA-COMP:17207, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:29973, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:57305, ChEBI:CHEBI:167890, ChEBI:CHEBI:456216;
CC Evidence={ECO:0000256|ARBA:ARBA00036933};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:67181;
CC Evidence={ECO:0000256|ARBA:ARBA00036933};
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, flagellum axoneme
CC {ECO:0000256|ARBA:ARBA00004611}.
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DR AlphaFoldDB; A0A2K5L7V7; -.
DR STRING; 9531.ENSCATP00000009021; -.
DR Ensembl; ENSCATT00000031745.1; ENSCATP00000009021.1; ENSCATG00000027450.1.
DR GeneTree; ENSGT00940000162265; -.
DR OMA; DDIHNVM; -.
DR Proteomes; UP000233060; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:Ensembl.
DR GO; GO:0015630; C:microtubule cytoskeleton; IEA:Ensembl.
DR GO; GO:0036126; C:sperm flagellum; IEA:Ensembl.
DR GO; GO:0070736; F:protein-glycine ligase activity, initiating; IEA:Ensembl.
DR GO; GO:0060271; P:cilium assembly; IEA:Ensembl.
DR GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR004344; TTL/TTLL_fam.
DR PANTHER; PTHR45870:SF3; PROTEIN MONOGLYCYLASE TTLL8; 1.
DR PANTHER; PTHR45870; TUBULIN MONOGLYCYLASE TTLL3; 1.
DR Pfam; PF03133; TTL; 1.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR PROSITE; PS51221; TTL; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT REGION 168..194
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 646..671
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..194
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 88028 MW; DBD51B13309FBC12 CRC64;
SIYGHYPVVR AALRRKGWVE KKFHFLPKVI PDVEDEGAGV ADVTCGKVKE NQEMALEKTD
DIHNVMSRLV KNEMPYLLWT IKRDAIDYHS LTCDQMLNHY AKTASFTTKI GLCVNMRSLP
WYVSANPDSF FPRCYSLCTE SEQQEFLEDF RRTMASSILK WVVSHQSCSR SGRSKPRGWR
EEAGNSDLSS RQDAENAEAK LRGLPSQLVD IACKVCQAYL GQLEHEDIDT SADAAEDLNT
LRRVGGPDTA RYYPQLSLQN YFPQCQALLN QITSVNPQTD IDGFRNIWII KPAAKSRGRG
ESPDIVCMDR VEEILELAAT DHPLPRDNKW VVQKYIETPL LIYDTKFDIR QWFLVTDWNP
LTIWFYKESY LRFSTQRFSL DKLDSAIHLC NNAVQKHLKN DVGRSPLLPA HNMWTSTKFQ
EYLQRQGRGA MWGSVIYPSM KKAIIHAMKV AQDHVEPRKN SFELYGADFV LGRDFRPWLI
EINSSPTMHP STPVTAQLCA QVQEDTIKVA VDRSCDVGNF ELLWRQPVVE LPPFSGSDLC
VAGVSVRRAR RQVLPACNLK ASALLLDTQP LEAQGPSAMP DPAQGSPRPA LQRDLGLKEE
KGHPLALLAP LRGLPESSGA PQPTRTKAAG KVELPACPCH HVDSQAPNTD VPEAQPTKHW
DPNQLNAHPP APVPQSLKTV EGALRPPPGG KGNLRRSRCE GARTAATCQT TGTAWDGWPG
ACSLQQLLAS EQPMGPGLPR DPRGLPCLVC RGLLPPAWPC KRCRSFRAAV LQGASFVPLG
GWSCSPRTP
//
