ID A0A2K5L8T9_CERAT Unreviewed; 775 AA.
AC A0A2K5L8T9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Myotubularin related protein 10 {ECO:0000313|Ensembl:ENSCATP00000009345.1};
GN Name=MTMR10 {ECO:0000313|Ensembl:ENSCATP00000009345.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000009345.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000009345.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR RefSeq; XP_011946698.1; XM_012091308.1.
DR AlphaFoldDB; A0A2K5L8T9; -.
DR Ensembl; ENSCATT00000032927.1; ENSCATP00000009345.1; ENSCATG00000027357.1.
DR GeneID; 105600284; -.
DR KEGG; caty:105600284; -.
DR CTD; 54893; -.
DR GeneTree; ENSGT00940000156900; -.
DR OrthoDB; 5474662at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000027357; Expressed in spleen and 12 other cell types or tissues.
DR CDD; cd13346; PH-GRAM_MTMR10; 1.
DR CDD; cd14593; PTP-MTMR10; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR036004; MTMR10_PH-GRAM.
DR InterPro; IPR030573; MTMR10_PTP.
DR InterPro; IPR022587; MTMR12-like_C.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF39; MYOTUBULARIN-RELATED PROTEIN 10; 1.
DR Pfam; PF12578; 3-PAP; 1.
DR Pfam; PF06602; Myotub-related; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 219..659
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 196..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 336..337
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 775 AA; 88320 MW; B8654A8E6AD34D2E CRC64;
MFSLKPPRPT FRSYLLPPPQ TDDKISSEPK IKKLEPVLLP GEIVVNEVNF VRKCIATDTS
QYDLWGKLIC SNFKISFITD DPMPLQKFHY RNLLLGEHDV PLTCIEQIVT VNDHKRKQKV
LGPNQKLKFN PTELIIYCKD FRIVRFRFDE SGPESAKKVC LAIAHYSQPT DLQLLFAFEY
VGKKYHNSAH KINGIPSGDG GGGGGDGAGG GSSQKTPLFE TYSDWDREIK RTGASGWRVC
SINEGYMIST CLPEYFVVPS SLADQDLKIF SHSFVGRRMP LWCWSHSNGS ALVRMALIKD
VLQQRKIDQR ICNAITKSHP QRSDVYKSDL DKTLPNIQEV QAAFVKLKQL CVNEPFEETE
EKWLSSLENT RWLEYVRAFL KHSAELVYML ESKHLSVVLQ EEEGRDLSCC VASLVQVMLD
PYFRTIIGFQ SLIQKEWVMA GYQFLDRCNH LKRSEKESPL FLLFLDATWQ LLEQYPAAFE
FSETYLAVLY DSTRISLFGT FLFNSPHQRV KQSTEFAISK NIQLGDEKGL QFPSVWDWSL
QFTAKDRTLF HNPFYIGKST PCVHNGSVKS FKRTKKNYSS TLRGMPSALK NGIISDQELL
PRRNSLILKP KPDPPQQTNS QNSDMEQYFR EWFSKPVNLH AVILPRVSGT HIKLWKLCYF
RWVPEAQISL GGSITAFHKL SLLADEVDVL SRTLRQQHSG PLEACYGELG QSRMYFRASG
PHDTDTSGTP EFLSSSFPFS PVGNLCRRSI LGTPLSKFLS GAKIWLSTET LANED
//
