ID A0A2K5LB46_CERAT Unreviewed; 331 AA.
AC A0A2K5LB46;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Acetylserotonin O-methyltransferase {ECO:0000256|ARBA:ARBA00040730};
DE EC=2.1.1.4 {ECO:0000256|ARBA:ARBA00039116};
DE AltName: Full=Hydroxyindole O-methyltransferase {ECO:0000256|ARBA:ARBA00043054};
GN Name=ASMT {ECO:0000313|Ensembl:ENSCATP00000010178.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000010178.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000010178.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Catalyzes the transfer of a methyl group onto N-
CC acetylserotonin, producing melatonin (N-acetyl-5-methoxytryptamine).
CC {ECO:0000256|ARBA:ARBA00037645}.
CC -!- PATHWAY: Aromatic compound metabolism; melatonin biosynthesis;
CC melatonin from serotonin: step 1/2. {ECO:0000256|ARBA:ARBA00037926}.
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DR AlphaFoldDB; A0A2K5LB46; -.
DR STRING; 9531.ENSCATP00000010178; -.
DR Ensembl; ENSCATT00000034284.1; ENSCATP00000010178.1; ENSCATG00000029353.1.
DR GeneTree; ENSGT00940000161561; -.
DR OMA; FWPYVFG; -.
DR Proteomes; UP000233060; Unplaced.
DR GO; GO:0017096; F:acetylserotonin O-methyltransferase activity; IEA:Ensembl.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0030187; P:melatonin biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd02440; AdoMet_MTases; 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR031725; ASMT_dimerisation.
DR InterPro; IPR016461; COMT-like.
DR InterPro; IPR001077; O_MeTrfase_dom.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11746:SF327; ACETYLSEROTONIN O-METHYLTRANSFERASE; 1.
DR PANTHER; PTHR11746; O-METHYLTRANSFERASE; 1.
DR Pfam; PF16864; Dimerisation2; 1.
DR Pfam; PF00891; Methyltransf_2; 1.
DR PIRSF; PIRSF005739; O-mtase; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51683; SAM_OMT_II; 1.
PE 4: Predicted;
KW Melatonin biosynthesis {ECO:0000256|ARBA:ARBA00043260};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022603}.
FT DOMAIN 12..99
FT /note="Acetylserotonin O-methyltransferase dimerisation"
FT /evidence="ECO:0000259|Pfam:PF16864"
FT DOMAIN 127..313
FT /note="O-methyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00891"
FT ACT_SITE 241
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR005739-1"
SQ SEQUENCE 331 AA; 36551 MW; FD346AEE930F8574 CRC64;
MGSSGDDGYR LLNEYTNGFM VSQVLFAACE LGVFDLLAEA PGPLDVAAVA AGVEASPHGT
ELLLDTCVSL KLLKVETRAG KAFYQNTELS SAYLTRVSPT SQCNLLKYMG RTSYGCWGHL
ADAVRWGLVA LHARSEGERL QFMQALQEVW SVNGRSVLTA FDLSGFPLMC DLGGGPGALA
KECLSLYPGC KVTVFDIPEV VRTAKQHFSF PEEEQIHFQE GDFFKDPLPE ADLYILARIL
HDWADGKCSH LLERVYHTCK PGGGILVIES LLDEDRRGPL LTQLYSLNML VQTEGQERTP
THYHMLLSSA GFRDFQFKKT GAIYDAILVR K
//
