ID A0A2K5LBE2_CERAT Unreviewed; 550 AA.
AC A0A2K5LBE2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=UDP glucuronosyltransferase family 2 member A1 complex locus {ECO:0000313|Ensembl:ENSCATP00000010273.1};
GN Name=UGT2A1 {ECO:0000313|Ensembl:ENSCATP00000010273.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000010273.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000010273.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=glucuronate acceptor + UDP-alpha-D-glucuronate = acceptor
CC beta-D-glucuronoside + H(+) + UDP; Xref=Rhea:RHEA:21032,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:58052, ChEBI:CHEBI:58223,
CC ChEBI:CHEBI:132367, ChEBI:CHEBI:132368; EC=2.4.1.17;
CC Evidence={ECO:0000256|ARBA:ARBA00000301};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004389}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004389}. Microsome membrane
CC {ECO:0000256|ARBA:ARBA00004111}; Single-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004111}.
CC -!- SIMILARITY: Belongs to the UDP-glycosyltransferase family.
CC {ECO:0000256|ARBA:ARBA00009995, ECO:0000256|RuleBase:RU003718}.
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DR AlphaFoldDB; A0A2K5LBE2; -.
DR Ensembl; ENSCATT00000034382.1; ENSCATP00000010273.1; ENSCATG00000029410.1.
DR GeneTree; ENSGT00940000161344; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000029410; Expressed in frontal cortex.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015020; F:glucuronosyltransferase activity; IEA:UniProtKB-EC.
DR CDD; cd03784; GT1_Gtf-like; 1.
DR Gene3D; 3.40.50.2000; Glycogen Phosphorylase B; 2.
DR InterPro; IPR002213; UDP_glucos_trans.
DR InterPro; IPR035595; UDP_glycos_trans_CS.
DR PANTHER; PTHR48043; EG:EG0003.4 PROTEIN-RELATED; 1.
DR PANTHER; PTHR48043:SF140; UDP-GLUCURONOSYLTRANSFERASE 2A1; 1.
DR Pfam; PF00201; UDPGT; 1.
DR SUPFAM; SSF53756; UDP-Glycosyltransferase/glycogen phosphorylase; 1.
DR PROSITE; PS00375; UDPGT; 1.
PE 3: Inferred from homology;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676,
KW ECO:0000256|RuleBase:RU003718};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Microsome {ECO:0000256|ARBA:ARBA00022848};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003718};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 514..537
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 550 AA; 62498 MW; 5AF9883734A0152C CRC64;
MVLKLKRKTF ASHLIKSSAS SHIMLNNLLL FSLQISLIGT TLGGNVLIWP MEGSHWLNVK
IIIDELIKKE HNVTVLVASG ALFITPTSNS SLTFEIYKVP FGKERIEGVI NDFVLTWLEN
RPSPSTIWRF YQKMAKAIKN FHIVSREICD GVLKNQQLME KLKKSKFEVL VSDPVFPCGD
IVALKLGIPF MYSLRFSPAS TVEKHCGKVP YPPSYVPAVL SELTDQMSFT DRIRNFISYH
LQDYMFETLW KSWDSYYSKA LGRPTTLCET MGKAEIWLIR TYWDFEFPRP YLPNFEFVGG
LHCKPAKSLP KEMEEFIQSS GKDGVVVFSL GSMVKNLTEE KANLIASALA QIPQKVLWRY
VGKKPATLGN NTQLYDWIPQ NDLLGHPKTK AFITHGGTNG IYEAIYHGVP MVGVPMFADQ
PDNIAHMKAK GAAVEVNLNT MTSVDLLSAL RTVINEPSYK ENAMRLSRIH HDQLVKPLDR
AVFWIEFVMR HKGAKHLRPA AHNLTWFQYH SLDVIGFLLV CVTMAIFLVI QCCLFSCQKF
GKIGKKKKRE
//
