ID A0A2K5LBV2_CERAT Unreviewed; 645 AA.
AC A0A2K5LBV2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN Name=CES2 {ECO:0000313|Ensembl:ENSCATP00000010433.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000010433.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000010433.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
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DR RefSeq; XP_011919009.1; XM_012063619.1.
DR AlphaFoldDB; A0A2K5LBV2; -.
DR STRING; 9531.ENSCATP00000010433; -.
DR ESTHER; cerat-a0a2k5lbv2; Carb_B_Chordata.
DR Ensembl; ENSCATT00000034546.1; ENSCATP00000010433.1; ENSCATG00000029478.1.
DR GeneID; 105587408; -.
DR KEGG; caty:105587408; -.
DR GeneTree; ENSGT00940000153793; -.
DR OrthoDB; 4386at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000029478; Expressed in colon and 12 other cell types or tissues.
DR GO; GO:0106435; F:carboxylesterase activity; IEA:Ensembl.
DR GO; GO:0006693; P:prostaglandin metabolic process; IEA:Ensembl.
DR CDD; cd00312; Esterase_lipase; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR019819; Carboxylesterase_B_CS.
DR PANTHER; PTHR11559; CARBOXYLESTERASE; 1.
DR PANTHER; PTHR11559:SF429; COCAINE ESTERASE; 1.
DR Pfam; PF00135; COesterase; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
DR PROSITE; PS00941; CARBOXYLESTERASE_B_2; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 115..623
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT REGION 63..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 645 AA; 71079 MW; 2DC986036DE17E9C CRC64;
MKGAFRPPCF CSGGSFTPIK FLPISPSVGF LNSCQTHLFL AQASAPPALF AQSKLRGWAR
PNPGQSLGEQ QRVHRQRTET SEPTMRLHRL RARLSAVACG LLLLLVQGQG QDSASPIRTT
HAGQVLGSLV HVKSADAGVH TFLGIPFAKP PLGALRFAPP EPPESWSGVR DGTTHPDACL
QDLTTMDSEV QSQVNVTIPS ISMSEDCLYL SIYTPAYSHE GSNLPVMVWI HGGGLVFGMA
SMYDGSMLAA FEDVVVVTIQ YRLGVLGFFS TGDKHATGNW GYLDQVAALR WVQQNIAHFG
GNPDRVTIFG ESAGGTSVSS LVVSPMSQGL FHGAIMESGV ALLPGLIASS ADVISTVVAN
LSACDQADSE ALVNCLRGKS KEEILAINKP FNMMIPGVVD GVFLPRHPQE MLASADFQAV
PSIIGINNDE FGWIIPKVTG IYDTQKEMDR EAFQAVLQKM LTLMMLPPTF GDLLMEEYVG
DNGEPQSLQA QLQEIMADSM FVIPALQVAH FQRSRAPVYF YEFQHQPSWV KNIRPPHVKA
DHGDELPFVF GNFFWGNYVK FTEEEERLSR KTMKYWANFA RNGNPNGVGL PHWPLFDQEE
QYLQLNLQPA VGRALKAHRF QFWKKALPQK KMQELEEPEE KHTEL
//
