ID A0A2K5LD15_CERAT Unreviewed; 918 AA.
AC A0A2K5LD15;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=DEAD/H-box helicase 11 {ECO:0000313|Ensembl:ENSCATP00000010849.1};
GN Name=DDX11 {ECO:0000313|Ensembl:ENSCATP00000010849.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000010849.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000010849.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC DDX11/CHL1 sub-subfamily. {ECO:0000256|ARBA:ARBA00008435}.
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DR AlphaFoldDB; A0A2K5LD15; -.
DR STRING; 9531.ENSCATP00000010849; -.
DR Ensembl; ENSCATT00000034967.1; ENSCATP00000010849.1; ENSCATG00000029545.1.
DR GeneTree; ENSGT00950000182970; -.
DR OMA; QTHQFRD; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000029545; Expressed in bone marrow and 8 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR GO; GO:0031390; C:Ctf18 RFC-like complex; IEA:Ensembl.
DR GO; GO:0030496; C:midbody; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0000922; C:spindle pole; IEA:Ensembl.
DR GO; GO:0043139; F:5'-3' DNA helicase activity; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0008186; F:ATP-dependent activity, acting on RNA; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0003688; F:DNA replication origin binding; IEA:Ensembl.
DR GO; GO:0051880; F:G-quadruplex DNA binding; IEA:Ensembl.
DR GO; GO:0016818; F:hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides; IEA:InterPro.
DR GO; GO:0003697; F:single-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0003727; F:single-stranded RNA binding; IEA:Ensembl.
DR GO; GO:0045142; F:triplex DNA binding; IEA:Ensembl.
DR GO; GO:1904976; P:cellular response to bleomycin; IEA:Ensembl.
DR GO; GO:0072719; P:cellular response to cisplatin; IEA:Ensembl.
DR GO; GO:0072711; P:cellular response to hydroxyurea; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0044806; P:G-quadruplex DNA unwinding; IEA:Ensembl.
DR GO; GO:1990700; P:nucleolar chromatin organization; IEA:Ensembl.
DR GO; GO:2000781; P:positive regulation of double-strand break repair; IEA:Ensembl.
DR GO; GO:0045876; P:positive regulation of sister chromatid cohesion; IEA:Ensembl.
DR GO; GO:1901838; P:positive regulation of transcription of nucleolar large rRNA by RNA polymerase I; IEA:Ensembl.
DR GO; GO:0031297; P:replication fork processing; IEA:Ensembl.
DR GO; GO:0007062; P:sister chromatid cohesion; IEA:Ensembl.
DR CDD; cd18788; SF2_C_XPD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 3.
DR InterPro; IPR006555; ATP-dep_Helicase_C.
DR InterPro; IPR045028; DinG/Rad3-like.
DR InterPro; IPR014013; Helic_SF1/SF2_ATP-bd_DinG/Rad3.
DR InterPro; IPR006554; Helicase-like_DEXD_c2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR010614; RAD3-like_helicase_DEAD.
DR InterPro; IPR013020; Rad3/Chl1-like.
DR NCBIfam; TIGR00604; rad3; 1.
DR PANTHER; PTHR11472:SF41; ATP-DEPENDENT DNA HELICASE DDX11-RELATED; 1.
DR PANTHER; PTHR11472; DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER; 1.
DR Pfam; PF06733; DEAD_2; 1.
DR Pfam; PF13307; Helicase_C_2; 1.
DR SMART; SM00488; DEXDc2; 1.
DR SMART; SM00491; HELICc2; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51193; HELICASE_ATP_BIND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 7..443
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51193"
FT REGION 199..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 287..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 125..178
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 918 AA; 103098 MW; CE08EEB2C0189598 CRC64;
METQKVGTIR FPFPFTPYSI QEDFMAELYR VLEVFFIGIF ESPTGTGKSL SLICGALSWL
RDFEQKKREE EAQLLETGTG PLHDEKDESL CLSSSCEGAA ATPRPAGEPA WVTQFVQKKE
ERDLVDRLKA EQARRKQREE RLQQLQHRAQ FKYAAKRLRQ EEEETENLLR LSREMLETGP
GAERPEQLES GEEELVLAEY ESDEEKKAAS GVDEEEDDLE EEHVTKIYYC SRTHSQLAQF
VHEVKKSPFG RDVRLVSLGS RQNLCVNEDV KSLGSVQLIN DRCVDMQRSR HEKKKGAEEE
KPKRRRQEKQ AACPFYNHEQ MGLLRDEALA EVKDIEQLLA LGKEARACPY YGSRLAIPAA
QLVVLPYQML LHAATRQAAG IRLQEQVVII DEAHNLIDTI TGMHSVEVSG SQLCQAHSQL
LQYMERYGKR LKAKNLMYLK QILYLLEKFV AVLGGESPIP LKNPNTQSSH AFVCLLSGTE
LKTINDFLFQ SQIDNINLFS WAWFLQVQRY CEKSMISRKL FGFTERYGAV LSSREQPKLA
GFQQFLQSLQ PRTTEAPAAP ADESQASAPR PASPLMHIEG FLAALTTANQ DGRVILSRQG
SLSQSTLKFL LLNPAVHFAQ VVKECRAVVI AGGTMQPVSD FRQQLLACAG VEAERVVEFS
CGHVIPPDNI LPLVICSGIS NQPLEFTFQK RELPQMMDEA GRILCNLCSV VPGGVVCFFP
SYEYLRQVHA HWEKGGLLGR LAARKKIFQE PKSAHQVEQV LLAYSRCIQA CGQERGRVTG
ALLLSVVGGK MSEGINFSDN LGRCVVMVGM PFPNIRSPEL QEKMAYLDQT LPRAPGQAPP
GKNLVENLCM KAVNQSIGRA IRHQKDFASI VLLDQRYARP PVLAKLPAWI RARVEVKATF
GPAIAAVQKF HREKSSSS
//
