ID A0A2K5LDZ2_CERAT Unreviewed; 497 AA.
AC A0A2K5LDZ2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=E3 ubiquitin-protein ligase XIAP {ECO:0000256|ARBA:ARBA00044089};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
DE AltName: Full=Baculoviral IAP repeat-containing protein 4 {ECO:0000256|ARBA:ARBA00044214};
DE AltName: Full=RING-type E3 ubiquitin transferase XIAP {ECO:0000256|ARBA:ARBA00044244};
DE AltName: Full=X-linked inhibitor of apoptosis protein {ECO:0000256|ARBA:ARBA00044224};
GN Name=XIAP {ECO:0000313|Ensembl:ENSCATP00000011169.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000011169.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000011169.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the IAP family. {ECO:0000256|ARBA:ARBA00006672}.
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DR RefSeq; XP_011916534.1; XM_012061144.1.
DR RefSeq; XP_011916535.1; XM_012061145.1.
DR RefSeq; XP_011916536.1; XM_012061146.1.
DR RefSeq; XP_011916537.1; XM_012061147.1.
DR RefSeq; XP_011916538.1; XM_012061148.1.
DR SMR; A0A2K5LDZ2; -.
DR STRING; 9531.ENSCATP00000011169; -.
DR Ensembl; ENSCATT00000035290.1; ENSCATP00000011169.1; ENSCATG00000029823.1.
DR Ensembl; ENSCATT00000035292.1; ENSCATP00000011171.1; ENSCATG00000029823.1.
DR GeneID; 105586304; -.
DR KEGG; caty:105586304; -.
DR CTD; 331; -.
DR GeneTree; ENSGT00940000158743; -.
DR OMA; CMDENIA; -.
DR OrthoDB; 383715at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000029823; Expressed in colon and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0043027; F:cysteine-type endopeptidase inhibitor activity involved in apoptotic process; IEA:Ensembl.
DR GO; GO:0061135; F:endopeptidase regulator activity; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0120283; F:protein serine/threonine kinase binding; IEA:Ensembl.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:Ensembl.
DR GO; GO:0042742; P:defense response to bacterium; IEA:Ensembl.
DR GO; GO:0006974; P:DNA damage response; IEA:Ensembl.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IEA:Ensembl.
DR GO; GO:0010804; P:negative regulation of tumor necrosis factor-mediated signaling pathway; IEA:Ensembl.
DR GO; GO:0051402; P:neuron apoptotic process; IEA:Ensembl.
DR GO; GO:0070427; P:nucleotide-binding oligomerization domain containing 1 signaling pathway; IEA:Ensembl.
DR GO; GO:0070431; P:nucleotide-binding oligomerization domain containing 2 signaling pathway; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IEA:Ensembl.
DR GO; GO:0046330; P:positive regulation of JNK cascade; IEA:Ensembl.
DR GO; GO:1902530; P:positive regulation of protein linear polyubiquitination; IEA:Ensembl.
DR GO; GO:0032481; P:positive regulation of type I interferon production; IEA:Ensembl.
DR GO; GO:0070534; P:protein K63-linked ubiquitination; IEA:Ensembl.
DR GO; GO:0060785; P:regulation of apoptosis involved in tissue homeostasis; IEA:Ensembl.
DR CDD; cd00022; BIR; 3.
DR CDD; cd16714; RING-HC_BIRC4_8; 1.
DR CDD; cd14395; UBA_BIRC4_8; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001370; BIR_rpt.
DR InterPro; IPR048875; BIRC2-3-like_UBA.
DR InterPro; IPR042579; XIAP/BIRC8_UBA.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR10044:SF115; E3 UBIQUITIN-PROTEIN LIGASE XIAP; 1.
DR PANTHER; PTHR10044; INHIBITOR OF APOPTOSIS; 1.
DR Pfam; PF00653; BIR; 3.
DR Pfam; PF21290; BIRC2-3-like_UBA; 1.
DR Pfam; PF13920; zf-C3HC4_3; 1.
DR SMART; SM00238; BIR; 3.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF57924; Inhibitor of apoptosis (IAP) repeat; 3.
DR PROSITE; PS01282; BIR_REPEAT_1; 2.
DR PROSITE; PS50143; BIR_REPEAT_2; 3.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 450..484
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
SQ SEQUENCE 497 AA; 56685 MW; DAD89D5E541861FD CRC64;
MTFNSFEGSK TCVPADINKE EEFVEEFNRL KTFADFPSSS PVSASTLARA GFLYTGEGDT
VRCFSCHAAV DRWQYGDSAV GRHRKVSPNC RFINGFYFEN SATQSTNSGI QNGQYKVENY
LGSRNHFALD RPSETHADYL LRTGQVVDIS DTIYPRNPAM YSEEARLKSF QNWPDYAHLT
PRELASAGLY YTGIGDQVQC FCCGGKLKNW EPCDRAWSEH RRHFPNCFFV LGRNLNIRSE
SDAVSSDRNF PNSTNLPRNP SMADYEARII TFGTWIYSVN KEQLARAGFY ALGEGDKVKC
FHCGGGLTDW KPSEDPWEQH AKWYPGCKYL LEQKGQEYIN NIHLTHSLEE CLVRTTEKTP
SLTRRIDDTI FQNPMVQEAI RMGFSFKDIK KIMEEKIQIS GSNYKSLEVL VADLVNAQKD
STQDESSQTS LQKEISTEEQ LRRLQEEKLC KICMDRNIAI VFVPCGHLVT CKQCAEAVDK
CPMCYTVITF KQKIFMS
//