ID A0A2K5LEN7_CERAT Unreviewed; 127 AA.
AC A0A2K5LEN7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=Mitochondrial pyruvate carrier {ECO:0000256|RuleBase:RU363100};
GN Name=MPC2 {ECO:0000313|Ensembl:ENSCATP00000011419.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000011419.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000011419.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Mediates the uptake of pyruvate into mitochondria.
CC {ECO:0000256|ARBA:ARBA00002429, ECO:0000256|RuleBase:RU363100}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in);
CC Xref=Rhea:RHEA:64720, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378;
CC Evidence={ECO:0000256|ARBA:ARBA00034982};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Mitochondrion
CC inner membrane {ECO:0000256|ARBA:ARBA00004448,
CC ECO:0000256|RuleBase:RU363100}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004448, ECO:0000256|RuleBase:RU363100}.
CC -!- SIMILARITY: Belongs to the mitochondrial pyruvate carrier (MPC) (TC
CC 2.A.105) family. {ECO:0000256|ARBA:ARBA00006416,
CC ECO:0000256|RuleBase:RU363100}.
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DR RefSeq; XP_011946487.1; XM_012091097.1.
DR AlphaFoldDB; A0A2K5LEN7; -.
DR STRING; 9531.ENSCATP00000011419; -.
DR Ensembl; ENSCATT00000035541.1; ENSCATP00000011419.1; ENSCATG00000029934.1.
DR GeneID; 105600193; -.
DR KEGG; caty:105600193; -.
DR CTD; 25874; -.
DR GeneTree; ENSGT00510000047120; -.
DR OMA; PQQFAIC; -.
DR OrthoDB; 590256at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000029934; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0005743; C:mitochondrial inner membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0050833; F:pyruvate transmembrane transporter activity; IEA:Ensembl.
DR GO; GO:0006086; P:acetyl-CoA biosynthetic process from pyruvate; IEA:Ensembl.
DR GO; GO:0006850; P:mitochondrial pyruvate transmembrane transport; IEA:Ensembl.
DR GO; GO:0035774; P:positive regulation of insulin secretion involved in cellular response to glucose stimulus; IEA:Ensembl.
DR InterPro; IPR005336; MPC.
DR PANTHER; PTHR14154:SF2; MITOCHONDRIAL PYRUVATE CARRIER 2; 1.
DR PANTHER; PTHR14154; UPF0041 BRAIN PROTEIN 44-RELATED; 1.
DR Pfam; PF03650; MPC; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128,
KW ECO:0000256|RuleBase:RU363100};
KW Mitochondrion inner membrane {ECO:0000256|ARBA:ARBA00022792,
KW ECO:0000256|RuleBase:RU363100};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU363100}.
SQ SEQUENCE 127 AA; 14309 MW; 2D2E5879AB2EF169 CRC64;
MSAAGARGLR ATYHRLLDKV ELMLPEKLRP LYNHPAGPRT VFFWAPIMKW GLVCAGLADM
ARPAEKLSTA QSAVLMATGF IWSRYSLVII PKNWSLFAVN FFVGTAGASQ LFRIWRYNQE
LKAKAHK
//
