ID A0A2K5LEV9_CERAT Unreviewed; 397 AA.
AC A0A2K5LEV9;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=acetyl-CoA C-acetyltransferase {ECO:0000256|ARBA:ARBA00012705};
DE EC=2.3.1.9 {ECO:0000256|ARBA:ARBA00012705};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000011491.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000011491.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
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DR RefSeq; XP_011905776.1; XM_012050386.1.
DR AlphaFoldDB; A0A2K5LEV9; -.
DR STRING; 9531.ENSCATP00000011491; -.
DR Ensembl; ENSCATT00000035614.1; ENSCATP00000011491.1; ENSCATG00000029973.1.
DR GeneID; 105581323; -.
DR KEGG; caty:105581323; -.
DR CTD; 39; -.
DR GeneTree; ENSGT01030000234626; -.
DR OMA; ICPSIAI; -.
DR OrthoDB; 5481312at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000029973; Expressed in liver and 12 other cell types or tissues.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR18919:SF171; ACETYL-COA ACETYLTRANSFERASE, CYTOSOLIC; 1.
DR PANTHER; PTHR18919; ACETYL-COA C-ACYLTRANSFERASE; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transferase {ECO:0000256|RuleBase:RU003557}.
FT DOMAIN 8..267
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 274..396
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 92
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 353
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 383
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 397 AA; 41299 MW; F709781AC9340E3F CRC64;
MNAGSDPVVI VSAARTIIGS FNGALATVPV QDLGSTVIKE VLKRATVVPE DVSEVIFGHV
LAAGCGQNPV RQASVGAGIP YSVPAWSCQM ICGSGLKAVC LAAQSIGIGD SSIVVAGGME
NMSKAPHLAH LRTGVKIGEM PLTDSILCDG LTDAFHNYHM GITAENVAKK WQVSREDQDK
VAVLSQNRTE NAQKAGHFDK EIVPVLVSSR KGLIEVKTDE FPRHGSNIED MSKLKPYFLT
DGTGTVTPAN ASGINDGAAA VVLMKKSEAD KRGLTPLAQI VSWSQVGVEP SIMGIGPIPA
IKQAVTKAGW SLEDVDVFEI NEAFAALSVA IVKELGLNPQ KVNIEGGAIA LGHPLGTSGC
RILVTLLHTL ERTGGIRGVA ALCIGGGMGI AMCVQRG
//
