ID   A0A2K5LF75_CERAT        Unreviewed;       586 AA.
AC   A0A2K5LF75;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   SubName: Full=Methyl-CpG binding domain protein 1 {ECO:0000313|Ensembl:ENSCATP00000011611.1};
GN   Name=MBD1 {ECO:0000313|Ensembl:ENSCATP00000011611.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000011611.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000011611.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   AlphaFoldDB; A0A2K5LF75; -.
DR   Ensembl; ENSCATT00000035737.1; ENSCATP00000011611.1; ENSCATG00000029959.1.
DR   GeneTree; ENSGT00950000183005; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000029959; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd01396; MeCP2_MBD; 1.
DR   InterPro; IPR016177; DNA-bd_dom_sf.
DR   InterPro; IPR001739; Methyl_CpG_DNA-bd.
DR   InterPro; IPR002857; Znf_CXXC.
DR   PANTHER; PTHR12396; METHYL-CPG BINDING PROTEIN, MBD; 1.
DR   PANTHER; PTHR12396:SF59; METHYL-CPG-BINDING DOMAIN PROTEIN 1; 1.
DR   Pfam; PF01429; MBD; 1.
DR   Pfam; PF02008; zf-CXXC; 3.
DR   SMART; SM00391; MBD; 1.
DR   SUPFAM; SSF54171; DNA-binding domain; 1.
DR   PROSITE; PS50982; MBD; 1.
DR   PROSITE; PS51058; ZF_CXXC; 3.
PE   4: Predicted;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00509}.
FT   DOMAIN          1..69
FT                   /note="MBD"
FT                   /evidence="ECO:0000259|PROSITE:PS50982"
FT   DOMAIN          169..216
FT                   /note="CXXC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51058"
FT   DOMAIN          217..263
FT                   /note="CXXC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51058"
FT   DOMAIN          307..355
FT                   /note="CXXC-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51058"
FT   REGION          80..123
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          267..309
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          368..435
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          461..502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        80..95
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        101..120
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        285..301
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        401..415
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        471..491
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   586 AA;  64693 MW;  85DDFF84EF6CCCA4 CRC64;
     MAEDWLDCPA LGPGWKRREV FRKSGATCGR SDTYYQSPTG DRIRSKVELT RYLGPACDLT
     LFDFKQGILC YPAPKAHPVA VASKKRKKPS RPAKTRKRQV GPQSGEVRKE APRDETKADT
     DTAPASFPAP GCCENCGISF SGDGTQRQRL KTLCKDCRAQ RIAFNREQRM FKRVGCGECA
     ACQVTEDCGA CSTCLLQLPH DVASGLFCKC ERRRCLRIVE RSRGCGVCRG CQTQEDCGRC
     PICLRPPRPG LRRQWKCVQR RCLRGKHSRR KGGCDSKMAA RRRPGAQPLP PPPPSQSPEP
     TEPQPYTNRR QNRKCGACAA CLRRMDCGRC DFCCDKPKFG GSNQKRQKCR WRQCLQFAMK
     RLLPSVWSES EDGAGSPPPY HRRKRPSSAR RHHLGPTLKP TLATRTAQPD HTQAPTKQEA
     GGGFVLPPPG TDLVFLREGA SSPVQVPGPV AASTEALLQA VDPGLPSVKQ EPPDPEEDKE
     ENKDDSASKL APEEEAGGAG TPVITEIFSL GGTRFRDTAV WLPSLQGRHS GREDGCKVWE
     TEDTVEPTST SWNPRGWPGT HVSLSPPPAS MMWVSCRRSW CPSSQS
//