ID A0A2K5LFE8_CERAT Unreviewed; 707 AA.
AC A0A2K5LFE8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=RING-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012483};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483};
GN Name=TRIM3 {ECO:0000313|Ensembl:ENSCATP00000011654.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000011654.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000011654.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900};
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DR AlphaFoldDB; A0A2K5LFE8; -.
DR Ensembl; ENSCATT00000035780.1; ENSCATP00000011654.1; ENSCATG00000029972.1.
DR GeneTree; ENSGT00940000158173; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000029972; Expressed in cerebellum and 11 other cell types or tissues.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd14960; NHL_TRIM2_like; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR003649; Bbox_C.
DR InterPro; IPR017868; Filamin/ABP280_repeat-like.
DR InterPro; IPR001298; Filamin/ABP280_rpt.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR001258; NHL_repeat.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR24104; E3 UBIQUITIN-PROTEIN LIGASE NHLRC1-RELATED; 1.
DR PANTHER; PTHR24104:SF21; TRIPARTITE MOTIF-CONTAINING PROTEIN 3; 1.
DR Pfam; PF00630; Filamin; 1.
DR Pfam; PF01436; NHL; 6.
DR Pfam; PF00643; zf-B_box; 1.
DR SMART; SM00502; BBC; 1.
DR SMART; SM00336; BBOX; 1.
DR SMART; SM00557; IG_FLMN; 1.
DR SUPFAM; SSF57845; B-box zinc-binding domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS50194; FILAMIN_REPEAT; 1.
DR PROSITE; PS51125; NHL; 6.
DR PROSITE; PS50119; ZF_BBOX; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}; Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00024}.
FT DOMAIN 82..126
FT /note="B box-type"
FT /evidence="ECO:0000259|PROSITE:PS50119"
FT REPEAT 280..381
FT /note="Filamin"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00087"
FT REPEAT 436..479
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 483..526
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 527..568
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 572..615
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 619..662
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REPEAT 663..706
FT /note="NHL"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00504"
FT REGION 381..427
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 707 AA; 76604 MW; 8EC8ADC9F0729CBC CRC64;
CYPIHSGLRL SFFLDRCLQN YIPAQSLTLS CPVCRQTSIL PEQGVSALQN NFFISSLMEA
MQQASDGAHD PEDPHPLSAV AGRPLSCPNH EGKTMEFYCE ACETAMCGEC RAGEHREHGT
HKAALQRQLE AVRGRLPQLS AAIALVGGIS QQLQERKAEA LAQIGAAFED LEQALQQRKQ
ALVRDLETIC GAKQKVLQTQ LDTLRQGQEH IGSSCSFAEQ ALRLGSAPEV LLVRKHMRER
LAALAAQAFP ERPHENAQLE LVLEVDGLRR SVLNLGALLT TSATAHETVA TGEGLRQALV
GQPASLTVTT KDKDGRLVRT GSAELRAEIT GPDGTRLPVP VVDHKNGTYE LVYTARTEGE
LLLSVLLYGQ PVRGSPFRVR ALRPGDLPPS PDDVKRRVKS PGGPGSHVRQ KAVRRPSSMY
STGGKRKDNP IEDELVFRVG SRGREKGEFT NLQGVSAASS GRIVVADSNN QCIQVFSNEG
QFKFRFGVRG RSPGQLQRPT GVAVDTNGDI IVADYDNRWV SIFSPEGKFK TKIGAGRLMG
PKGVAVDRNG HIIVVDNKSC CVFTFQPNGK LVGRFGGRGA TDRHFAGPHF VAVNNKNEIV
VTDFHNHSVK VYSADGEFLF KFGSHGEGNG QFNAPTGVAV DSNGNIIVAD WGNSRIQVFD
SSGSFLSYIN TSAEPLYGPQ GLALTSDGHV VVADAGNHCF KAYRYLQ
//
