ID A0A2K5LFM1_CERAT Unreviewed; 562 AA.
AC A0A2K5LFM1;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Acid sensing ion channel subunit 1 {ECO:0000313|Ensembl:ENSCATP00000011702.1};
GN Name=ASIC1 {ECO:0000313|Ensembl:ENSCATP00000011702.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000011702.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000011702.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the amiloride-sensitive sodium channel (TC
CC 1.A.6) family. ASIC1 subfamily. {ECO:0000256|ARBA:ARBA00038517}.
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DR RefSeq; XP_011903718.1; XM_012048328.1.
DR AlphaFoldDB; A0A2K5LFM1; -.
DR STRING; 9531.ENSCATP00000011702; -.
DR Ensembl; ENSCATT00000035828.1; ENSCATP00000011702.1; ENSCATG00000030053.1.
DR GeneID; 105580362; -.
DR CTD; 41; -.
DR GeneTree; ENSGT00940000158414; -.
DR OrthoDB; 3415680at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000030053; Expressed in cerebellum and 2 other cell types or tissues.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098793; C:presynapse; IEA:GOC.
DR GO; GO:0044736; F:acid-sensing ion channel activity; IEA:Ensembl.
DR GO; GO:0015280; F:ligand-gated sodium channel activity; IEA:InterPro.
DR GO; GO:0022839; F:monoatomic ion-gated channel activity; IEA:Ensembl.
DR GO; GO:0008306; P:associative learning; IEA:Ensembl.
DR GO; GO:0001662; P:behavioral fear response; IEA:Ensembl.
DR GO; GO:0070588; P:calcium ion transmembrane transport; IEA:Ensembl.
DR GO; GO:0071467; P:cellular response to pH; IEA:Ensembl.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0046929; P:negative regulation of neurotransmitter secretion; IEA:Ensembl.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR GO; GO:0010447; P:response to acidic pH; IEA:Ensembl.
DR GO; GO:0001975; P:response to amphetamine; IEA:Ensembl.
DR GO; GO:0050915; P:sensory perception of sour taste; IEA:Ensembl.
DR Gene3D; 2.60.470.10; Acid-sensing ion channels like domains; 1.
DR Gene3D; 1.10.287.770; YojJ-like; 2.
DR InterPro; IPR001873; ENaC.
DR InterPro; IPR004724; ENaC_chordates.
DR InterPro; IPR020903; ENaC_CS.
DR NCBIfam; TIGR00859; ENaC; 1.
DR PANTHER; PTHR11690:SF170; ACID-SENSING ION CHANNEL 1; 1.
DR PANTHER; PTHR11690; AMILORIDE-SENSITIVE SODIUM CHANNEL-RELATED; 1.
DR Pfam; PF00858; ASC; 1.
DR PRINTS; PR01078; AMINACHANNEL.
DR PROSITE; PS01206; ASC; 1.
PE 3: Inferred from homology;
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022461}.
FT REGION 13..59
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 562 AA; 62764 MW; 07E1D60384C79709 CRC64;
MPIRIFCSVS FSSGEEAPGP LGDIWGPHHH QQQQDISESE EEEEEKEKEA VRKETSKRHS
PMDLVAFANS CTLHGTNHIF VEGGPGPRQA LWAVAFVLAL GAFLCQVGDR VAYYLSYPHV
TLLNEVATTE LAFPAVTLCN TNAVRLSQLS YPDLLYLAPM LGLDESDDPG VPLAPPGPEA
FSGEPFNLHR FYNRSCHRLE DMLLYCSYQG GPCGPHNFSV VFTRYGKCYT FNSGRDGRPR
LKTVKGGTGN GLEIMLDIQQ DEYLPVWGET DETSFEAGIK VQIHSQDEPP FIDQLGFGVA
PGFQTFVACQ EQRLIYLPPP WGTCKAVTMD SDLDFFDSYS ITACRIDCET RYLVENCNCR
MVHMPGDAPY CTPEQYKECA DPALDFLVEK DQEYCVCEMP CNLTRYGKEL SMVKIPSKAS
AKYLAKKFNK SEQYIGENIL VLDIFFEVLN YETIEQKKAY EIAGLLGDIG GQMGLFIGAS
ILTVLELFDY AYEVIKHKLC RRGKCQKEAK RSSADKGVAL SLDDVKRHNP CESLRGHPAG
MTYAANILPH HPARGTFEDF TC
//
