ID A0A2K5LGR0_CERAT Unreviewed; 419 AA.
AC A0A2K5LGR0;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=WT1 interacting protein {ECO:0000313|Ensembl:ENSCATP00000012163.1};
GN Name=WTIP {ECO:0000313|Ensembl:ENSCATP00000012163.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000012163.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000012163.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the zyxin/ajuba family.
CC {ECO:0000256|ARBA:ARBA00009611}.
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DR AlphaFoldDB; A0A2K5LGR0; -.
DR STRING; 9531.ENSCATP00000012163; -.
DR Ensembl; ENSCATT00000036291.1; ENSCATP00000012163.1; ENSCATG00000030260.1.
DR GeneTree; ENSGT00940000160924; -.
DR OMA; EPAQFPF; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000030260; Expressed in heart and 8 other cell types or tissues.
DR GO; GO:0000932; C:P-body; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003714; F:transcription corepressor activity; IEA:Ensembl.
DR GO; GO:0007010; P:cytoskeleton organization; IEA:Ensembl.
DR GO; GO:0035278; P:miRNA-mediated gene silencing by inhibition of translation; IEA:Ensembl.
DR GO; GO:0035331; P:negative regulation of hippo signaling; IEA:Ensembl.
DR GO; GO:0022604; P:regulation of cell morphogenesis; IEA:Ensembl.
DR GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR CDD; cd09352; LIM1_Ajuba_like; 1.
DR CDD; cd09355; LIM2_Ajuba_like; 1.
DR Gene3D; 2.10.110.10; Cysteine Rich Protein; 3.
DR InterPro; IPR047172; Ajuba-like.
DR InterPro; IPR047245; Ajuba-like_LIM1.
DR InterPro; IPR047247; Ajuba-like_LIM2.
DR InterPro; IPR001781; Znf_LIM.
DR PANTHER; PTHR24219; LIM DOMAIN-CONTAINING PROTEIN JUB; 1.
DR PANTHER; PTHR24219:SF6; WILMS TUMOR PROTEIN 1-INTERACTING PROTEIN; 1.
DR Pfam; PF00412; LIM; 2.
DR SMART; SM00132; LIM; 3.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 2.
DR PROSITE; PS00478; LIM_DOMAIN_1; 1.
DR PROSITE; PS50023; LIM_DOMAIN_2; 2.
PE 3: Inferred from homology;
KW LIM domain {ECO:0000256|ARBA:ARBA00023038, ECO:0000256|PROSITE-
KW ProRule:PRU00125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00125}; Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-mediated gene silencing {ECO:0000256|ARBA:ARBA00023158};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00125}.
FT DOMAIN 223..284
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT DOMAIN 288..348
FT /note="LIM zinc-binding"
FT /evidence="ECO:0000259|PROSITE:PS50023"
FT REGION 21..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..190
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 43656 MW; 0E3D62C14CFF5E1B CRC64;
MQRSRAAADE AALLLAGLAL RELEPGGCSP GRGRRGPRPG PGDEAAPALG RRGKGGGGPE
AGADGLSRGE RGPRRAAAPE VSAQPAGSPR ASLAGSDGGG GGGSARSSGI SLGYDQRHGS
PRSGRSDPRP GPGPPSVGSA RSSVSSLGSR GSAGAYADLL PPGACPAPAR SPEPAGPAPF
PLPALPLPPG REGGPSAAER RLEALTRELE RALEARTARD YFGICIKCGL GIYGAQQACQ
AMGSLYHTDC FTCDSCGRRL RGKAFYNVGE KVYCQEDFLY SGFQQTADKC SVCGHLIMEM
ILQALGKSYH PGCFRCSVCN ECLDGVPFTV DVENNIYCVR DYHTVFAPKC ASCARPILPA
QVGATHPEMI RCLDCGLQLS GEEGRRCYPL AGHLLCRRCH LRRLQPGPVP SPTVHVTEL
//
