ID A0A2K5LJU2_CERAT Unreviewed; 494 AA.
AC A0A2K5LJU2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=H2.0 like homeobox {ECO:0000313|Ensembl:ENSCATP00000013202.1};
GN Name=HLX {ECO:0000313|Ensembl:ENSCATP00000013202.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000013202.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000013202.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|PROSITE-ProRule:PRU00108,
CC ECO:0000256|RuleBase:RU000682}.
CC -!- SIMILARITY: Belongs to the H2.0 homeobox family.
CC {ECO:0000256|ARBA:ARBA00038504}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011896032.1; XM_012040642.1.
DR AlphaFoldDB; A0A2K5LJU2; -.
DR STRING; 9531.ENSCATP00000013202; -.
DR Ensembl; ENSCATT00000037339.1; ENSCATP00000013202.1; ENSCATG00000030743.1.
DR GeneID; 105576987; -.
DR KEGG; caty:105576987; -.
DR CTD; 3142; -.
DR GeneTree; ENSGT00950000183093; -.
DR OMA; EPMNEAS; -.
DR OrthoDB; 2911948at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000030743; Expressed in skeletal muscle tissue and 7 other cell types or tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IEA:Ensembl.
DR GO; GO:0048484; P:enteric nervous system development; IEA:Ensembl.
DR GO; GO:0050673; P:epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0001889; P:liver development; IEA:Ensembl.
DR GO; GO:0045629; P:negative regulation of T-helper 2 cell differentiation; IEA:Ensembl.
DR GO; GO:0035265; P:organ growth; IEA:Ensembl.
DR GO; GO:0050679; P:positive regulation of epithelial cell proliferation; IEA:Ensembl.
DR GO; GO:0046622; P:positive regulation of organ growth; IEA:Ensembl.
DR GO; GO:0045627; P:positive regulation of T-helper 1 cell differentiation; IEA:Ensembl.
DR GO; GO:0007519; P:skeletal muscle tissue development; IEA:Ensembl.
DR GO; GO:0045063; P:T-helper 1 cell differentiation; IEA:Ensembl.
DR GO; GO:0045064; P:T-helper 2 cell differentiation; IEA:Ensembl.
DR CDD; cd00086; homeodomain; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR InterPro; IPR000047; HTH_motif.
DR PANTHER; PTHR46808; H2.0-LIKE HOMEOBOX PROTEIN; 1.
DR PANTHER; PTHR46808:SF1; H2.0-LIKE HOMEOBOX PROTEIN; 1.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR PRINTS; PR00031; HTHREPRESSR.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; Homeodomain-like; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Homeobox {ECO:0000256|ARBA:ARBA00023155, ECO:0000256|PROSITE-
KW ProRule:PRU00108};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00108}; Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 280..340
FT /note="Homeobox"
FT /evidence="ECO:0000259|PROSITE:PS50071"
FT DNA_BIND 282..341
FT /note="Homeobox"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00108"
FT REGION 119..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 337..494
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..153
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 337..356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 368..382
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 494 AA; 51488 MW; E165993A44EF8007 CRC64;
MFAAGLAPFY ASNFSLWSAA YCSSTGPGGC SFPLDPAAVK KPSFCIADIL HAGVGDLGAA
PEGLAGASAA ALTAHLGSVH PHASFQAAAR SPLRPTPVVA PSEVQAGFPQ RLSPLSAAYH
HHHPQQQQHQ QQQPQQQQPP QQQPPPPPRA GALQPPASGT RVVPNPHHSG SAPAPSSKDL
KFGIDRILSA EFDPKVKEGN TLRDLTSLLT GGRPAGVHLS GLQPSAGQFF ASLDPINEAS
AILSPLSSNP RNSVQHQFQD TFPGPYAVLT KDTMPQTYKR KRSWSRAVFS NLQRKGLEKR
FEIQKYVTKP DRKQLAAMLG LTDAQVKVWF QNRRMKWRHS KEAQAQKDKD KEAGEKPSGG
GPAADGEQDE RSPSRSEGEA ESESSDSESL DMAPSDTERT EGTERSLHQT TVIKAPVTGA
LISASSAGSG GSSGGGGSSF SFSSASSLSS SSTSAGCASS LGGGGASELL PVPQPTASSA
PKSPEPPKGA LGGV
//
