ID A0A2K5LK01_CERAT Unreviewed; 1453 AA.
AC A0A2K5LK01;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 {ECO:0000313|Ensembl:ENSCATP00000013276.1};
GN Name=ARAP1 {ECO:0000313|Ensembl:ENSCATP00000013276.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000013276.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000013276.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9531.ENSCATP00000013276; -.
DR Ensembl; ENSCATT00000037414.1; ENSCATP00000013276.1; ENSCATG00000030588.1.
DR GeneTree; ENSGT00940000157424; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000030588; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005547; F:phosphatidylinositol-3,4,5-trisphosphate binding; IEA:Ensembl.
DR GO; GO:0051497; P:negative regulation of stress fiber assembly; IEA:Ensembl.
DR GO; GO:0051491; P:positive regulation of filopodium assembly; IEA:Ensembl.
DR GO; GO:0008360; P:regulation of cell shape; IEA:Ensembl.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08837; ArfGap_ARAP; 1.
DR CDD; cd13253; PH1_ARAP; 1.
DR CDD; cd13254; PH2_ARAP; 1.
DR CDD; cd13256; PH3_ARAP; 1.
DR CDD; cd13257; PH4_ARAP; 1.
DR CDD; cd17226; RA_ARAP1; 1.
DR CDD; cd04385; RhoGAP_ARAP; 1.
DR CDD; cd09490; SAM_Arap1_2_3; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR037858; RhoGAP_ARAP.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR001660; SAM.
DR InterPro; IPR013761; SAM/pointed_sf.
DR PANTHER; PTHR45899:SF3; ARF-GAP WITH RHO-GAP DOMAIN, ANK REPEAT AND PH DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR45899; RHO GTPASE ACTIVATING PROTEIN AT 15B, ISOFORM C; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00536; SAM_1; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 5.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00454; SAM; 1.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 4.
DR SUPFAM; SSF47769; SAM/Pointed domain; 1.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 3.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50105; SAM_DOMAIN; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 10..64
FT /note="SAM"
FT /evidence="ECO:0000259|PROSITE:PS50105"
FT DOMAIN 326..418
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 439..528
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 534..659
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 742..849
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 953..1138
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 1171..1260
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT REGION 68..144
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..301
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..102
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..219
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..285
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1453 AA; 162709 MW; AA3FF1D3B01B4D97 CRC64;
MAEAGDAALS VAEWLRALHL EQYTGLFEQH GLVWATECQG LSDARLMDMG MLLPGHRRRI
LAGLLRAHTP PAPAPRPTPR PVPMKRHIFR SPPAPATPPE PLPTATEDEG LPTAPPIPPR
RSCLPPTCFT TPSTAAPDPV LPPLPAKRHL AELSVPPVPP RTGPPRLLLS LPTKEEESLL
PLSSLPQPEP EDPLSALPQG PPQPHSPPPC PPEIPPKPVR LFPEFDDSDY DEVPEEGPGA
PARVMTKKEE PPLSRVPRAV RVASLLSEGE ELSGDDQEDG DEDDHAYEGV PNGGWHTSSL
SLSLPSTIAA PHPMDGPPGG STPVTPVIKA GWLDKNPPQG SYIYQKRWVR LDTDHLRYFD
SNKDAYSKRF ISVACISRVA AIGDQKFEVI TNNRTFAFRA ESDVERKEWM QALQQAMAEQ
RARARLSSAY LLGVPGSEQP DRAGSLELRG FKNKLYVAVV GDKVQLYKNL EEYHLGIGIT
FIDMSVGNVK EVDRRSFDLT TPYRIFSFSA DSELEKEQWL EAMQGAVAEA LSTSEVAERV
WAAAPNRFCA DCGAPQPDWA SINLCVVICK RCAGEHRGLG AGVSKVRSLK MDRKVWTETL
IELFLQLGNG AGNRFWAANV PPSEALQPSS SPSTRRCHLE AKYREGKYRR YHPLFGNQEE
LDKALCAAVT TTDLAETQAL LGCGAGISCF SGDPEAPTPL ALAEQAGQTL QMEFLRNNRT
TEVPRLDSMK PLEKHYSVIL PTVSHSGFLY KTASAGKLLQ DRRAREEFSR RWCVLSDGVL
SYYENERAVT PNGEIRASEI VCLAVPLPDT HGFEHTFEVY TEGERLYLFG LESMEQAHEW
VKCIAKAFVP PLAEDLLARD FERLGRLPYK AGLSLQRAQE GWFSLSGSEL RAVFPEGPCE
EPLQLRKLQE LSIQGDSENQ VLVLVERRRT LYIQGERRLD FMGWLGAIQK AAASMGDTLS
EQQLGDSDIP VIVYRCVDYI TQCGLTSEGI YRKCGQTSKT QRLLESLRQD ARSVHLKEGE
QHVDDVSSAL KRFLRDLPDG LFTRAQRLAW LEASEIEDEE EKVSRYRELL VWLPPVNRAT
VKALISHLYC VQCFSDTNQM NVHNLAIVFG PTLFQTDGQD YKAGRVVEDL INHYVVVFSV
DEEELRKQRE EITAIVKMRV AGTASGTQHA GDFICTVYLE EKKAETEQHV KIPASMTAEE
LTLEILDRRN VGIREKDYWT CFEVNEREEA ERPLHFAEKV LPILHGLGTD SHLVVKKHQA
MEAMLLYLAS RVSDTKHGMM KFREDRSLLG LGLPSGGFHD RYFILNSSCL RLYKEVRSQR
PWSGAPETSH RPEKEWPVKS LRVYLGVKKK LRPPTCWRHF WEGWADLRLN VWPRPLSAPQ
HDGLVWPSEP SRVSRAVPEV RLGSVSLIPL RGSENEMRRS VAAFTADPLS VPSRCLRNWR
YMAGDWNRFL ESC
//
