GenomeNet

Database: UniProt
Entry: A0A2K5LM84_CERAT
LinkDB: A0A2K5LM84_CERAT
Original site: A0A2K5LM84_CERAT 
ID   A0A2K5LM84_CERAT        Unreviewed;       821 AA.
AC   A0A2K5LM84;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 31.
DE   SubName: Full=Neuronal PAS domain protein 2 {ECO:0000313|Ensembl:ENSCATP00000014013.1};
GN   Name=NPAS2 {ECO:0000313|Ensembl:ENSCATP00000014013.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000014013.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000014013.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; A0A2K5LM84; -.
DR   STRING; 9531.ENSCATP00000014013; -.
DR   Ensembl; ENSCATT00000038155.1; ENSCATP00000014013.1; ENSCATG00000031061.1.
DR   GeneTree; ENSGT00940000160744; -.
DR   OMA; RPCRMPL; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000031061; Expressed in heart and 10 other cell types or tissues.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR   GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR   GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
DR   GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR   GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR   CDD; cd00130; PAS; 2.
DR   Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR   Gene3D; 3.30.450.20; PAS domain; 2.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR047230; CLOCK-like.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR001067; Nuc_translocat.
DR   InterPro; IPR001610; PAC.
DR   InterPro; IPR000014; PAS.
DR   InterPro; IPR035965; PAS-like_dom_sf.
DR   InterPro; IPR013767; PAS_fold.
DR   NCBIfam; TIGR00229; sensory_box; 1.
DR   PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR   PANTHER; PTHR46055:SF1; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 2; 1.
DR   Pfam; PF00010; HLH; 1.
DR   Pfam; PF00989; PAS; 1.
DR   Pfam; PF14598; PAS_11; 1.
DR   PRINTS; PR00785; NCTRNSLOCATR.
DR   SMART; SM00353; HLH; 1.
DR   SMART; SM00086; PAC; 1.
DR   SMART; SM00091; PAS; 2.
DR   SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR   SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR   PROSITE; PS50888; BHLH; 1.
DR   PROSITE; PS50112; PAS; 2.
PE   4: Predicted;
KW   Activator {ECO:0000256|ARBA:ARBA00023159};
KW   Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          10..60
FT                   /note="BHLH"
FT                   /evidence="ECO:0000259|PROSITE:PS50888"
FT   DOMAIN          83..146
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   DOMAIN          261..308
FT                   /note="PAS"
FT                   /evidence="ECO:0000259|PROSITE:PS50112"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          393..470
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          553..664
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          678..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          736..821
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        393..432
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        553..663
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        737..787
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        788..802
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        804..821
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   821 AA;  91548 MW;  709768AB392CAF84 CRC64;
     HDASQKRHAK SKASRNKSEK KRRDQFNVLI KELSSMLPGN TRKMDKTTVL EKVIGFLQKH
     NEVSAQTEIC DIQQDWKPSF LSNEEFTQLM LEALDGFIIA VTTDGSIIYV SDSITPLLGH
     LPSDVMDQNL LNFLPEQEHS EVYKILSSHM LVTDSPSPEY LKSDSDLEFY CHLLRGSLNP
     KEFPTYEYIK FVGNFRSYNN VPSPSCNGFD NTLSRPCRVP LGKEVCFIAT VRLATPQFLK
     EMCIVDEPLE EFTSRHSLEW KFLFLDHRAP PIIGYLPFEV LGTSGYDYYH IDDLELLARC
     HQHLMQFGKG KSCCYRFLTK GQQWIWLQTH YYITYHQWNS KPEFIVCTHS VVRYRARRQE
     LALEDPPSED CSMCVFQDKG SSLEPRQHFN ALDVGTSGLN TSHSPSASSR SSHKSSHTAT
     SEPTSTPTKL MAEASTPALP RSATLPQELP VPGLSQAATM PAPLPSPSSC DLTQQLLPQT
     VLQSTPAPMA QFSAQFSMFQ TIKDQLEQRT RILQANIRWQ QEELHKIQEQ LCLVQDSNVQ
     MFLQQPAVSL SFSSTQRPEA QQQLQQRSAA VTQPQLGTGP QLPGQISSAQ VTSQHLLRES
     SVISTQGPKP MRSSQLMQSS GRSGSSLVSP FSSATAVLPP SLNLTTPAST SQDASQCQPS
     PDFSHDRQLR LLLSQPIQPM MPGSCDARQP SEVSRTGRQV KYAQSQTVFP NPDAHPVNSS
     SAPMPVLLMG QAVLHPSFPA SQPSPLQPAQ ARQQPPQHYL QVQAPTSLHS EQQDSLLLST
     YSQQPGTLGY PQPPPAQPQP LRPPRRVSSL SESSGLQQPP R
//
DBGET integrated database retrieval system