ID A0A2K5LM84_CERAT Unreviewed; 821 AA.
AC A0A2K5LM84;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 31.
DE SubName: Full=Neuronal PAS domain protein 2 {ECO:0000313|Ensembl:ENSCATP00000014013.1};
GN Name=NPAS2 {ECO:0000313|Ensembl:ENSCATP00000014013.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000014013.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000014013.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5LM84; -.
DR STRING; 9531.ENSCATP00000014013; -.
DR Ensembl; ENSCATT00000038155.1; ENSCATP00000014013.1; ENSCATG00000031061.1.
DR GeneTree; ENSGT00940000160744; -.
DR OMA; RPCRMPL; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000031061; Expressed in heart and 10 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0051879; F:Hsp90 protein binding; IEA:Ensembl.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR GO; GO:0032922; P:circadian regulation of gene expression; IEA:InterPro.
DR GO; GO:0006974; P:DNA damage response; IEA:UniProtKB-KW.
DR GO; GO:0045739; P:positive regulation of DNA repair; IEA:Ensembl.
DR GO; GO:0045893; P:positive regulation of DNA-templated transcription; IEA:Ensembl.
DR GO; GO:0051775; P:response to redox state; IEA:Ensembl.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 4.10.280.10; Helix-loop-helix DNA-binding domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR047230; CLOCK-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013767; PAS_fold.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR46055; CIRCADIAN LOCOMOTER OUTPUT CYCLES PROTEIN KAPUT; 1.
DR PANTHER; PTHR46055:SF1; NEURONAL PAS DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF00010; HLH; 1.
DR Pfam; PF00989; PAS; 1.
DR Pfam; PF14598; PAS_11; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 10..60
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 83..146
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 261..308
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 393..470
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 553..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 678..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 736..821
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 393..432
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 553..663
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 737..787
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 788..802
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 804..821
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 821 AA; 91548 MW; 709768AB392CAF84 CRC64;
HDASQKRHAK SKASRNKSEK KRRDQFNVLI KELSSMLPGN TRKMDKTTVL EKVIGFLQKH
NEVSAQTEIC DIQQDWKPSF LSNEEFTQLM LEALDGFIIA VTTDGSIIYV SDSITPLLGH
LPSDVMDQNL LNFLPEQEHS EVYKILSSHM LVTDSPSPEY LKSDSDLEFY CHLLRGSLNP
KEFPTYEYIK FVGNFRSYNN VPSPSCNGFD NTLSRPCRVP LGKEVCFIAT VRLATPQFLK
EMCIVDEPLE EFTSRHSLEW KFLFLDHRAP PIIGYLPFEV LGTSGYDYYH IDDLELLARC
HQHLMQFGKG KSCCYRFLTK GQQWIWLQTH YYITYHQWNS KPEFIVCTHS VVRYRARRQE
LALEDPPSED CSMCVFQDKG SSLEPRQHFN ALDVGTSGLN TSHSPSASSR SSHKSSHTAT
SEPTSTPTKL MAEASTPALP RSATLPQELP VPGLSQAATM PAPLPSPSSC DLTQQLLPQT
VLQSTPAPMA QFSAQFSMFQ TIKDQLEQRT RILQANIRWQ QEELHKIQEQ LCLVQDSNVQ
MFLQQPAVSL SFSSTQRPEA QQQLQQRSAA VTQPQLGTGP QLPGQISSAQ VTSQHLLRES
SVISTQGPKP MRSSQLMQSS GRSGSSLVSP FSSATAVLPP SLNLTTPAST SQDASQCQPS
PDFSHDRQLR LLLSQPIQPM MPGSCDARQP SEVSRTGRQV KYAQSQTVFP NPDAHPVNSS
SAPMPVLLMG QAVLHPSFPA SQPSPLQPAQ ARQQPPQHYL QVQAPTSLHS EQQDSLLLST
YSQQPGTLGY PQPPPAQPQP LRPPRRVSSL SESSGLQQPP R
//