ID A0A2K5LM97_CERAT Unreviewed; 311 AA.
AC A0A2K5LM97;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Caspase 1 {ECO:0000313|Ensembl:ENSCATP00000014085.1};
GN Name=CASP1 {ECO:0000313|Ensembl:ENSCATP00000014085.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000014085.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000014085.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134, ECO:0000256|RuleBase:RU003971}.
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DR AlphaFoldDB; A0A2K5LM97; -.
DR Ensembl; ENSCATT00000038230.1; ENSCATP00000014085.1; ENSCATG00000031081.1.
DR GeneTree; ENSGT00940000159114; -.
DR OMA; CVHKEKD; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000031081; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00032; CASc; 1.
DR Gene3D; 3.40.50.1460; -; 1.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR033139; Caspase_cys_AS.
DR InterPro; IPR016129; Caspase_his_AS.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR002138; Pept_C14_p10.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR47901; CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 18; 1.
DR PANTHER; PTHR47901:SF3; CASPASE-1; 1.
DR Pfam; PF00656; Peptidase_C14; 1.
DR PIRSF; PIRSF038001; Caspase_ICE; 1.
DR PRINTS; PR00376; IL1BCENZYME.
DR SMART; SM00115; CASc; 1.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR PROSITE; PS01122; CASPASE_CYS; 1.
DR PROSITE; PS01121; CASPASE_HIS; 1.
DR PROSITE; PS50207; CASPASE_P10; 1.
DR PROSITE; PS50208; CASPASE_P20; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protease {ECO:0000256|ARBA:ARBA00022670};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807};
KW Zymogen {ECO:0000256|ARBA:ARBA00023145}.
FT DOMAIN 68..196
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
FT DOMAIN 224..309
FT /note="Caspase family p10"
FT /evidence="ECO:0000259|PROSITE:PS50207"
SQ SEQUENCE 311 AA; 35218 MW; AE6248A01CF3FF86 CRC64;
MADKVLKEKR KLFIHSTGEA SLAMQDNPAM PTSSGSKGNV KLCSQEEAQR IWKEKPAEIY
PIMVKSGRTR LALIICNEEF DTLPRRTGAE VDITGMTMLL QNLGYNVHVR KNLTALEMTT
ELEAFAHRPE HKTSDSTFLV FMSHGIREGI CGKKYSEQVP DVLQLNAIFE MLNTRNCPSL
KDKPKVIIIQ ACRGENHGVV WLKDSAGVCR NVSLPTTEEF EVDAIKKAHI EKDFIAFCSS
TPDNVSWRHP TKGSVFIIRL IEHIQEYACS CDVEEIFRKV RLSFEQPGGR VQMPTTERVT
LTRCFYLFPG H
//
