ID A0A2K5LMT7_CERAT Unreviewed; 731 AA.
AC A0A2K5LMT7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=T cell activation RhoGTPase activating protein {ECO:0000313|Ensembl:ENSCATP00000014269.1};
GN Name=TAGAP {ECO:0000313|Ensembl:ENSCATP00000014269.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000014269.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000014269.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011905794.1; XM_012050404.1.
DR AlphaFoldDB; A0A2K5LMT7; -.
DR STRING; 9531.ENSCATP00000014269; -.
DR Ensembl; ENSCATT00000038415.1; ENSCATP00000014269.1; ENSCATG00000031180.1.
DR GeneID; 105581335; -.
DR KEGG; caty:105581335; -.
DR CTD; 117289; -.
DR GeneTree; ENSGT00940000157993; -.
DR OMA; NTKPEFN; -.
DR OrthoDB; 2964977at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000031180; Expressed in lung and 4 other cell types or tissues.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0035023; P:regulation of Rho protein signal transduction; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04402; RhoGAP_ARHGAP20; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR047886; ARHGAP20-like_RhoGAP.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23179; T-CELL ACTIVATION RHO GTPASE ACTIVATING PROTEIN-RELATED; 1.
DR PANTHER; PTHR23179:SF26; T-CELL ACTIVATION RHO GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 88..277
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 298..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 633..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 298..334
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 373..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 462..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 492..508
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 731 AA; 80812 MW; 1576763113204AA3 CRC64;
MKLRSSHNAS KTLNASNMET LIECQSEGDI KEHPLLASCE SEDSICQLIE VKKRKKVLSW
PFLMRRLSPA SDFSGALETD LKASLFDQPL SIICGGSDTL PRPIQDILTI LCLKGPSTEG
IFRRAANEKA RKELKEELNS GDAVDLESLP VHLLAVVFKD FLRSIPRKLL SSDLFEEWMG
TLEMQDEEDR IEALKQVADK LPRPNLLLLK HLVYVLHLIS KNSEVNRMDS SNLAICIGPN
MLTLENDQCL SFEAQKDLNN KVKTLVEFLI DNCFEIFGEN IPVHSSITSV DSLEHTDSSD
VSTLQNDSAY DSNDPDVESN SSSGISSPSR QPQVPMATAA GFDSGGPQDA REVSPEPIVS
TVARLKSSLA QPDRRYSEPS MPSSQECLES RVTNQTLTKS EGDFPVPRVG SRLEREEAED
PFPEEVFPAV QGKTKRPVDL KIKNLTPGSV LPRALVPKAF SSSSLDASSD SSPVASPSSP
KRNFFSRHQS FTTKTEKGKP SREIKKHSMS FSFAPHKKVL TKNLSAGSGK LQDFTRDHVP
RGVRKESQLA GRIVQENGSE THNQTTRAFC LRPHALSVDD VFQGADWERP GSPPSYAEAM
QGPAARLAAY GSQTVGSMTV GSMRARMLEV DSLLPPLPPA HHTGDSRHRD SKEPLPGHGL
SPLPERWKQS RTVHASWDSL GHVSGPGRPE LLRLRTVSES VQRNKRDCLM RRCSQPVFEA
DQFQHAKESY I
//
