ID A0A2K5LNC4_CERAT Unreviewed; 514 AA.
AC A0A2K5LNC4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Chromodomain helicase DNA binding protein 2 {ECO:0000313|Ensembl:ENSCATP00000014456.1};
GN Name=CHD2 {ECO:0000313|Ensembl:ENSCATP00000014456.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000014456.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000014456.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the SNF2/RAD54 helicase family.
CC {ECO:0000256|ARBA:ARBA00007025}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011933111.1; XM_012077721.1.
DR AlphaFoldDB; A0A2K5LNC4; -.
DR Ensembl; ENSCATT00000038603.1; ENSCATP00000014456.1; ENSCATG00000031069.1.
DR GeneID; 105594037; -.
DR CTD; 1106; -.
DR GeneTree; ENSGT00940000155888; -.
DR OrthoDB; 5482994at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000031069; Expressed in thymus and 12 other cell types or tissues.
DR CDD; cd18666; CD1_tandem_CHD1-2_like; 1.
DR CDD; cd18661; CD2_tandem_CHD1-2_like; 1.
DR Gene3D; 2.40.50.40; -; 2.
DR Gene3D; 3.40.50.10810; Tandem AAA-ATPase domain; 1.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR InterPro; IPR038718; SNF2-like_sf.
DR PANTHER; PTHR45623:SF19; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 2; 1.
DR PANTHER; PTHR45623; CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED-RELATED; 1.
DR Pfam; PF00385; Chromo; 2.
DR SMART; SM00298; CHROMO; 2.
DR SUPFAM; SSF54160; Chromo domain-like; 2.
DR PROSITE; PS00598; CHROMO_1; 2.
DR PROSITE; PS50013; CHROMO_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 274..366
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT DOMAIN 391..469
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 32..256
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 39..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 96..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 137..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 152..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 190..213
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 229..248
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 514 AA; 58682 MW; 4C582E2C7509ACD5 CRC64;
MTHKQRENYL NLSPCIFTWY RRFSQLVFDG EKLSHSASEE ASGSDSGSQS ESEQGSDPGS
GHGSESNSSS ESSESQSESE SESAGSKSQP VLPEAKEKPA SKKERIADVK KMWEEYPDVY
GVRRSNRSRQ EPSRFNIKEE ASSGSESGSP KRRGQRQLKK QEKWKREPSE DEQEQGTSAE
SEPEQKKVKA RRPVPRRTVP KPRVKKQPKT QRGKRKKQDS SDEDDDDDEA PKRQTRRRAA
KNVSYKEDDD FETDSDDLIE MTGEGVDEQQ DNSETIEKVL DSRLGKKGAT GASTTVYAIE
ANGDPSGDFD TEKDEGEIQY LIKWKGWSYI HSTWESEESL QQQKVKGLKK LENFKKKEDE
IKQWLGKVSP EDVEYFNCQQ ELASELNKQY QIVERVIAVK TSKSTLGQTD FPAHSRKPAP
SNEPEYLCKW MGLPYSECSW EDEALIGKKF QNCIDSFHSR NNSKTIPTRE CKALKQRPRF
VALKKQPAYL GGENLELRDY QLEGLNWLAH SWCK
//
