ID A0A2K5LQV2_CERAT Unreviewed; 1914 AA.
AC A0A2K5LQV2;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Rho guanine nucleotide exchange factor 17 {ECO:0000313|Ensembl:ENSCATP00000015313.1};
GN Name=ARHGEF17 {ECO:0000313|Ensembl:ENSCATP00000015313.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000015313.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000015313.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR Ensembl; ENSCATT00000039466.1; ENSCATP00000015313.1; ENSCATG00000031638.1.
DR GeneTree; ENSGT00940000153798; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000031638; Expressed in heart and 10 other cell types or tissues.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR039919; ARHGEF10/ARHGEF17.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR12877; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR12877:SF15; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 17; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF19056; WD40_2; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 943..1105
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 1..242
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 259..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 299..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..836
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 915..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1415..1435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1469..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1841..1874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1887..1906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 68..83
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..123
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..168
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 544..562
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 627..646
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 654..681
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 694..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1490..1538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1853..1868
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1890..1904
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1914 AA; 205792 MW; 7CE765183F5B7937 CRC64;
MRKLFGGPGS RRPSADSESP GTPSPDGAAW EPPARESRQP PTPPPRTCFP LVGLRSARPL
TGPGIEGRLR RQQQQQQQQQ ERALRPADGL HSWHIFSQPQ AGARASCSSS SSIASSYRVS
RSRAASSSEE EEEGPPQPPG AQSPAYHSGH SSGSDDDRDG EGGHRWGGRP RLRPGSSLLD
QDCRPDSDGL NLSSMDSAGG ARSPEPPASP RAPGEEGLRE WGSGSPPCVP GPQEGLRPMS
DSVGGALRVA KVSFPSYLAS PAGSCGSSRY SSTETLKDDD LWSSRGSGGW GVYRSPSFGA
GEGLLRSQAR TRAKGPGGIS RALRDGGFEP EKSRQRKSLS NPDIASETLT LLSFLRSDLS
ELRVRKPGGS PGDRVSSPLD GRDSPSAGGS MGQVEPVSIP APASPGTRPT LKDLTATLRR
AKSFTCSEKP MARRLPRTSA LKPSSSELLL AGPSAEEDPL PLIVQDQYVQ EARQVFEKIQ
RMGAQQDDGS DAPPESPDWA RDVTRGQRSQ EELSGPESSL TDEGIGADPE PPVAVFCGLG
TTGMWRPLSS SSAQTNHRSP GTEDSLGGWA LVSPEIPSTP GALRRRRKVP PSGSGGSELS
NGEAGEAYRS LSDPIPQRHR AATSEEPTGF SVDSNLLGSL SPKTGLPATS AMDEGLTSGH
SDWSVGSEES KGYQEVIQSI VQGPGTLGRV VDDRVAGKAP KKKSLSDPSR RGELVGPGFQ
GPGGEPIREV EPVLPPSSSE PILVEQRAEP EEPGAARSRA QSERALPEAL PPPATAHQNF
HLDPKLADIL SPRLIRRGSK KRPARSSHQE LGRDEGSQDQ IGGLSRARPS SKHVRHASVP
ATFMPIVVPE PPTSVGHPVA VPEPIGFPAR AHPTLQAPSL EDVTKQYMLN LHSGEVPTPV
PVDMPCLPLA ALPSAETKPP EAARPPDEPA PASKCCSKPQ VGYMQPLKQP ENSVLCDPAL
VDEIFDQIPE LLEHHEQFLE QVRHCVHSWH AQQKVGALLV QSFSKDVLVN IYSAYIDNFL
NAKDAVRVAK EARPAFLKFL EQSMRENKEK QALSDLMIKP VQRIPRYELL VKDLLKHTPE
DHPDHPLLLE AQRNIKQVAE RINKGVRSAE EAERHARVLQ EIEAHIEGME DLQAPLRRFL
RQEMVVEVKA ISGKKDRSLF LFTDLIVCTT LKRKSGSLRR SSMSLYTAAS VIDTASKYKM
LWKLPLEDTD IIKGASQATN RENIQKAISR LDEDLTTLGQ MSKLSESLGF PHQSLDDALR
DLSAAMHRDL SEKQALCYAL SFPPTKLELC TTRPEGTDSY IFEFPHPDAR LGFEQAFDEA
KRKLASSKSC LDPEFLKAIP IMKTRSGMQF SCAAPTLNSC PEPSPEVWVC NSDGYVGQVC
LLSLRAEPDV EACIAVCSAR ILCIGAVPGL QRRCHREPPP SLRSPSETAP EPAGPELDVE
AAADEEAATL AEPGPQPCLH ISIAGSGLEM TPGLAEGDPR PELVPFDSDS DDESSPSPSG
TLQSQASRST ISSSFGNEET PSSKEATAET TSSEEEQEPG FLPLSGSFGP GGPCSTSPMD
GRALRRSSRG SFTRGSLEDL LSVDPEAYQS SVWLGTEDGC VHVYQSSDSI RDRRNSMKLQ
HAASVTCILY LNNQVFVSLA NGDLVVYQRE AGHFWDPQNF KSVTLGAQGS PITKMVSVGG
RLWCGCQNRV LVLSPDTLQL EHTFYVGQDS SRSVACMVDS SLGVWVTLKG SAHVCLYHPD
TFEQLAEVDV TPPVHRMLAG SDAIIRQHKA ACLRITALLV CEELLWVGTS AGVVLTMPTS
PSTVSCPRAP LSPTGLGQGH TGHVRFLATV QLPDGFNLLC PTPPPAPDTG PEKLPSLEHR
DSPRHRGPAS ARPKMLVISG GDGYEDFRLS SGGGSSSETV GRDDSTNHLL LWRV
//
