ID A0A2K5LRM8_CERAT Unreviewed; 784 AA.
AC A0A2K5LRM8;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=NFKB repressing factor {ECO:0000313|Ensembl:ENSCATP00000015596.1};
GN Name=NKRF {ECO:0000313|Ensembl:ENSCATP00000015596.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000015596.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000015596.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the CARF family.
CC {ECO:0000256|ARBA:ARBA00010053}.
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DR AlphaFoldDB; A0A2K5LRM8; -.
DR STRING; 9531.ENSCATP00000015596; -.
DR Ensembl; ENSCATT00000039750.1; ENSCATP00000015596.1; ENSCATG00000031763.1.
DR GeneTree; ENSGT00940000157256; -.
DR OMA; SVLWTNH; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000031763; Expressed in frontal cortex and 12 other cell types or tissues.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0003676; F:nucleic acid binding; IEA:UniProtKB-UniRule.
DR CDD; cd02640; R3H_NRF; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.30.1370.50; R3H-like domain; 1.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR000467; G_patch_dom.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR034071; R3H_NRF.
DR InterPro; IPR021859; XTBD.
DR PANTHER; PTHR16148:SF15; NF-KAPPA-B-REPRESSING FACTOR; 1.
DR PANTHER; PTHR16148; NF-KAPPA-B-REPRESSING FACTOR-RELATED; 1.
DR Pfam; PF01585; G-patch; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF11952; XTBD; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00443; G_patch; 1.
DR SMART; SM00393; R3H; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF82708; R3H domain; 1.
DR PROSITE; PS50174; G_PATCH; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS51827; XTBD; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 38..125
FT /note="XRN2-binding (XTBD)"
FT /evidence="ECO:0000259|PROSITE:PS51827"
FT DOMAIN 645..690
FT /note="G-patch"
FT /evidence="ECO:0000259|PROSITE:PS50174"
FT DOMAIN 694..758
FT /note="R3H"
FT /evidence="ECO:0000259|PROSITE:PS51061"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 226..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..33
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..172
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 230..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 508..524
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 784 AA; 88132 MW; 844C9CB6F365E2A6 CRC64;
MAGGRLLLGG DFLSPPPLPP LPPPPLPPLP PPPPEPVLEQ WRYSHESDWQ WALRRSFICR
HLHSYPGAAL DQLLALSAAW TNHVFLGCRY SPRLMEKILQ MAEGIDIGEM PSYDLVLSKP
SKGQKRHLST CDGQNPPKKQ AGSKFHARPR FEPVHFVASS SKDERQEDPY GPQTKEVNEQ
THFASMPRDI YQDYTQDSFS IQDGNSQYCD SSGFILTKDQ PVAANMYFDS GNPAPSSTSQ
QANSQSTPEP SPSQTFPESV VAEKQYFIEK LTATIWKNLS NPEMTSGSDK INYTYMLTRC
IQACKTNPEY IYAPLKEIPP ADIPKNKKLL TDGYACEVRC QNIYLTTGYA GSKNGSRDRA
TELAVKLLQK RIEVRVVRRK FKHTFGEDLV VCQIGMSSYE FPPALKPPED LVVLGKDASG
QPVFNASAKH WTNFVITENA NDAIGILNNS ASFNKMSIEY KYEMMPNRTW RCRVFLQDHC
LAEGYGTKKT SKHAAADEAL KILQKTQPTY PSVKSSQCHT GSSPRGSGKK KDIKDLVVYE
NSSNPVCTLN DTAQFNRMTV EYVYERMTGL RWKCKVILES EVIAEAVGVK KTVKYEAAGE
AVKTLKKTQP TVINNLKKGA VEDVISRNEI QGRSAEEAYK QQIKEDNIGN QLLRKMGWTG
GGLGKSGEGI REPISVKEQH KREGLGLDVE RVNKIAKRDI EQIIRNYARS ESHTDLTFSR
ELTNDERKQI HQIAQKYGLK SKSHGVGHDR YLVVGRKRRK EDLLDQLKQE GQVGHYELVM
PQAN
//
