ID A0A2K5LRV6_CERAT Unreviewed; 673 AA.
AC A0A2K5LRV6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Interferon gamma inducible protein 16 {ECO:0000313|Ensembl:ENSCATP00000015668.1};
GN Name=IFI16 {ECO:0000313|Ensembl:ENSCATP00000015668.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000015668.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000015668.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR AlphaFoldDB; A0A2K5LRV6; -.
DR Ensembl; ENSCATT00000039824.1; ENSCATP00000015668.1; ENSCATG00000031785.1.
DR GeneTree; ENSGT00390000013296; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000031785; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0002218; P:activation of innate immune response; IEA:InterPro.
DR GO; GO:0035458; P:cellular response to interferon-beta; IEA:InterPro.
DR CDD; cd08305; Pyrin; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 4.
DR InterPro; IPR004020; DAPIN.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR040205; HIN-200.
DR InterPro; IPR004021; HIN200/IF120x.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR PANTHER; PTHR12200:SF5; GAMMA-INTERFERON-INDUCIBLE PROTEIN 16; 1.
DR PANTHER; PTHR12200; INTERFERON-INDUCIBLE PROTEIN AIM2 FAMILY MEMBER; 1.
DR Pfam; PF02760; HIN; 2.
DR Pfam; PF02758; PYRIN; 1.
DR SMART; SM01289; PYRIN; 1.
DR SUPFAM; SSF159141; HIN-2000 domain-like; 4.
DR PROSITE; PS50824; DAPIN; 1.
DR PROSITE; PS50834; HIN_200; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 1..88
FT /note="Pyrin"
FT /evidence="ECO:0000259|PROSITE:PS50824"
FT DOMAIN 133..333
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT DOMAIN 450..649
FT /note="HIN-200"
FT /evidence="ECO:0000259|PROSITE:PS50834"
FT REGION 88..134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 330..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 107..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 344..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 673 AA; 76009 MW; 58740190BA897A02 CRC64;
MEKKYKNIVL LKGLEVINDY HFRMVKSLLS KDLKLNVKMR EEYDKIQIAD LMEEKFRGDA
GLGKLIQIFK DIPTLEDLAE TLKKEKLKAK QLAPSRKRKK EVDPASPAPS TSGTVNTEGA
EATPGAQNPK TVAKCPVTPR KNILQKGPVI VKVLSTTKPF EYETPEMEKK TMFHATVATQ
TQFFHVKVLN TNLKEKFNGK KIIVISDYLE YDSLLEVNEE SSVSEAGPNQ MFEVPNKIIN
RAKETLKTDI LHKQASGNIV YGIFMLHKKT VNQKTTIYEI QDDRGKMDVV GTGQCHNIPC
EEGDKLQLYC FRLRKKNQMS KLISEMHSFI QVKKKPNPKN NDPKSMKPPQ EQSQLPNPSE
AGKTFPASHL QTPQMPPTTL SSSFFIKKSE DTITKMNDLM SMQILKEKSH FPGPFMTSIG
TADSHLHTPQ MPPSIPSSSC LTMLTPRLRT GPEEVSTEDG VQSDLKEVMV LNATESFVYE
PIEQKKMFHA TVATENEVFR VKVFNIDLKE KFTPKKIIAI SNYVCRSGFL EVYPLTVVVD
VNADRKMEIP QGLIRSANTT PKISYLCSQT KGSFVNGVFE VHKKNVRGEF TYYEIQDNTG
KMEVVVHGRL TTINCEEGDK LKLTCFELAP KSGNNGELRS VIHSHIKVIK ARKNKKDIFN
PDSSMETSPG FFF
//
