ID A0A2K5LT54_CERAT Unreviewed; 262 AA.
AC A0A2K5LT54;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE SubName: Full=Transmembrane protein 106A {ECO:0000313|Ensembl:ENSCATP00000016126.1};
GN Name=TMEM106A {ECO:0000313|Ensembl:ENSCATP00000016126.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000016126.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000016126.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the TMEM106 family.
CC {ECO:0000256|ARBA:ARBA00008111}.
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DR RefSeq; XP_011902197.1; XM_012046807.1.
DR RefSeq; XP_011902198.1; XM_012046808.1.
DR RefSeq; XP_011902199.1; XM_012046809.1.
DR AlphaFoldDB; A0A2K5LT54; -.
DR STRING; 9531.ENSCATP00000016126; -.
DR Ensembl; ENSCATT00000040284.1; ENSCATP00000016126.1; ENSCATG00000032003.1.
DR GeneID; 105579707; -.
DR KEGG; caty:105579707; -.
DR CTD; 113277; -.
DR GeneTree; ENSGT00940000161546; -.
DR OrthoDB; 5353335at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000032003; Expressed in spleen and 10 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0035780; P:CD80 biosynthetic process; IEA:Ensembl.
DR GO; GO:0035781; P:CD86 biosynthetic process; IEA:Ensembl.
DR GO; GO:0042116; P:macrophage activation; IEA:Ensembl.
DR GO; GO:0043123; P:positive regulation of canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:0032731; P:positive regulation of interleukin-1 beta production; IEA:Ensembl.
DR GO; GO:0032755; P:positive regulation of interleukin-6 production; IEA:Ensembl.
DR GO; GO:0043410; P:positive regulation of MAPK cascade; IEA:Ensembl.
DR GO; GO:0045348; P:positive regulation of MHC class II biosynthetic process; IEA:Ensembl.
DR GO; GO:1904407; P:positive regulation of nitric oxide metabolic process; IEA:Ensembl.
DR GO; GO:0032760; P:positive regulation of tumor necrosis factor production; IEA:Ensembl.
DR InterPro; IPR009790; TMEM106.
DR InterPro; IPR048509; TMEM106_C.
DR InterPro; IPR048511; TMEM106_N.
DR PANTHER; PTHR28556:SF3; TRANSMEMBRANE PROTEIN 106A; 1.
DR PANTHER; PTHR28556; TRANSMEMBRANE PROTEIN 106B; 1.
DR Pfam; PF07092; TMEM106; 1.
DR Pfam; PF21002; TMEM106_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 94..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 2..93
FT /note="Transmembrane protein 106 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF21002"
FT DOMAIN 116..252
FT /note="Transmembrane protein 106 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07092"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 262 AA; 28814 MW; 1C9CA82D8218B777 CRC64;
MGKTFSQLGS WREDENKSIL PSNPAIGSQA VSYFSTGSSK SLCSCVPCEG TAGASFVTCP
TCQGSGKIPQ ELEKQLVALI PYGDQRLKPK HTKLFVFLAV LICLVTSSFI IFFLFPRSVV
VQPAGLNSST VAFDEADIYL NITNVLNISN GNYYPITVTQ LTLEVLHLSL VVGQVSNNLL
LHIGPLTSEQ MFYTVATKIP DENTYKICTW LEIKVHHVLL HIQGTLTCSY LSHSEQLVFQ
SYEYVDCRGN ASVPHQLTPH PP
//
