ID A0A2K5LU19_CERAT Unreviewed; 1450 AA.
AC A0A2K5LU19;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=protein-serine/threonine phosphatase {ECO:0000256|ARBA:ARBA00013081};
DE EC=3.1.3.16 {ECO:0000256|ARBA:ARBA00013081};
GN Name=SSH2 {ECO:0000313|Ensembl:ENSCATP00000016441.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000016441.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000016441.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-threonyl-[protein] = L-threonyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:47004, Rhea:RHEA-COMP:11060, Rhea:RHEA-
CC COMP:11605, ChEBI:CHEBI:15377, ChEBI:CHEBI:30013, ChEBI:CHEBI:43474,
CC ChEBI:CHEBI:61977; EC=3.1.3.16;
CC Evidence={ECO:0000256|ARBA:ARBA00001482};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC {ECO:0000256|ARBA:ARBA00009580}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR RefSeq; XP_011927891.1; XM_012072501.1.
DR STRING; 9531.ENSCATP00000016441; -.
DR Ensembl; ENSCATT00000040602.1; ENSCATP00000016441.1; ENSCATG00000032138.1.
DR GeneID; 105591555; -.
DR KEGG; caty:105591555; -.
DR CTD; 85464; -.
DR GeneTree; ENSGT00940000157430; -.
DR OMA; EYTHTAT; -.
DR OrthoDB; 5490735at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000032138; Expressed in skeletal muscle tissue and 12 other cell types or tissues.
DR GO; GO:0003779; F:actin binding; IEA:InterPro.
DR GO; GO:0017018; F:myosin phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity; IEA:InterPro.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0030837; P:negative regulation of actin filament polymerization; IEA:InterPro.
DR CDD; cd14569; DSP_slingshot_2; 1.
DR CDD; cd11652; SSH-N; 1.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR014876; DEK_C.
DR InterPro; IPR000340; Dual-sp_phosphatase_cat-dom.
DR InterPro; IPR043587; Phosphatase_SSH-like.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR043588; SSH-N.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR InterPro; IPR020422; TYR_PHOSPHATASE_DUAL_dom.
DR PANTHER; PTHR45864:SF3; PROTEIN PHOSPHATASE SLINGSHOT HOMOLOG 2; 1.
DR PANTHER; PTHR45864; SLINGSHOT PROTEIN PHOSPHATASE HOMOLOG; 1.
DR Pfam; PF08766; DEK_C; 1.
DR Pfam; PF00782; DSPc; 1.
DR SMART; SM00195; DSPc; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR PROSITE; PS51998; DEK_C; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT DOMAIN 275..330
FT /note="DEK-C"
FT /evidence="ECO:0000259|PROSITE:PS51998"
FT DOMAIN 332..475
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50054"
FT DOMAIN 399..453
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 648..668
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 693..755
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 824..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 905..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1069
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1134
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1171..1206
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 693..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 724..743
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..932
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..961
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1450 AA; 160944 MW; B6FDCF1419C3575A CRC64;
MALVTVQRSP TPSTTSSPCA SSSHLEDSES AALLCCECEE SEIFSDSNEA DSGEEECRSQ
PRSISESFLT VKGAALFLPR GNGSSTPRIS HRRNKHAGDL QQHLQAMFIL LRPEDNIRLA
VRLESTYQNR TRYMVVVSTN GRQDTEESIV LGMDFSSNDS STCTMGLVLP LWSDTLIHLD
GDGGFSVSTD NRVHIFKPVS VQAMWSALQS LHKACEVARA HNYYPGSLFL TWVSYYESHI
NSDQSSVNEW NAMQDVQSHR PDSPALFTDI PTERERTERL IKTKLREIMM QKDLENITSK
EIRTELEMQM VCNLKKIKEF IDNEMIVILG QMDSQKKIFE HVFLGSEWNA SNLEDLQNRG
VRYILNVTRE IDNFFPGVFE YHNIRVYDEE ATDLLAYWND TYKFISKAKK HGSKCLVHCK
MGVSRSASTV IAYAMKEYGW NLDRAYDYVK ERRTVTKPNP SFMRQLEEYQ GILLASKQRH
NKLWRSHSDS DLSDHHEPIC KPGLELNKKE ITTSADQIAE VKTMESHPPI PPVFVEHVVP
QDANQKGLCT KERMICLEFT STEFHAGQIE DELNLNDING CSSGCCLNES KFPLDNCHAS
KALIQPGHVP EMANKFPDLT VEDLETDALK ADMNVHLLPM EELTSRLKDL PMSPDPESPS
PQPSCQTEIS DFSTDRIDFF SALEKFVELS QETRSRSFSH SRMEELGGGR SESCRLSVVE
VAPSKVTTDD QRSSSLSNTP HASEESSMDE EQSKTISELV SPDIFMQSHL ENAISVKEIV
TEIESISQGV GQIQLKGDIL SNPCHTPKKN SIHELLFERA QTPENKPGHL EQDEGSCTAQ
PELAKDSGMC NPEGCLTTRS STADLEEGEP AEGEQELQGS GMHPGAKWYP GSVRRATLEF
EERLRQEQEH HGAASTCTSL STRKNSKNDS SVADLAPKGK SDEATPEHSF VPKEPEMSKG
KGKYSGPEAG SLSHSEQNAT VPAPKVLGFD HLPAPQEGPG SDTGTQQEGV LKDLRTVIPY
QESETQAVPL RLPKRVEIIE YTHTVTSPNH TGPGSEIATG EKSGEQGLRK VNVEKSVTVL
CTLDENLNRT LDPNQVSLHP QVLPPPHSSS PEHNRPTDHR TSTLSGPEDR GSSLSTALET
AAPFVSHTTH LLSASLDYLH PQTMVHLEGF TEQSSTTDEP SAEQVSWEES QDSPLSSGSE
VPYKDSQLSS ADLSLISKLG DNTGELQEKL DPLPVACRLP HSSSSENIKG LSHSPGVVKE
RAKEIESRVV FQAGLTKPSQ MRRSASLAKL GYLDLCKDCL PEREPASCES PHLKLLQPFL
RTDSGMHAME DQESLENPGA PHNPEPTKYF VEQLTTTECI VQSKPVERPL VQYAKEFGSS
QQCLLPRAGP ELTSSEGGLP MLQTQGLQCA CPAPGLAVAP RQQHGRTHPL RRLKKANDKK
RTTNPFYNTM
//
