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Database: UniProt
Entry: A0A2K5LUW1_CERAT
LinkDB: A0A2K5LUW1_CERAT
Original site: A0A2K5LUW1_CERAT 
ID   A0A2K5LUW1_CERAT        Unreviewed;       914 AA.
AC   A0A2K5LUW1;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   05-JUN-2019, entry version 8.
DE   RecName: Full=Neuropilin {ECO:0000256|PIRNR:PIRNR036960};
GN   Name=NRP2 {ECO:0000313|Ensembl:ENSCATP00000016733};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000016733, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000016733, ECO:0000313|Proteomes:UP000233060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
RA   Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
RA   Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M.,
RA   Gross S., Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V.,
RA   Khan Z., Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G.,
RA   Ongeri F., Osuji N., Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R.,
RA   Reid J.G., Santibanez J., Scheel M., Sexton D., Shah N., Skinner E.,
RA   Vee V., Wu Y., Han Y., Muzny D.M., Richards S., Worley K.C.,
RA   Rogers J., Gibbs R.A.;
RT   "Sooty reference genome and diversity panel.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCATP00000016733}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the neuropilin family.
CC       {ECO:0000256|PIRNR:PIRNR036960}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR   Ensembl; ENSCATT00000040895; ENSCATP00000016733; ENSCATG00000032051.
DR   GeneTree; ENSGT00940000155270; -.
DR   Proteomes; UP000233060; Whole Genome Shotgun Assembly.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR   GO; GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
DR   GO; GO:0001525; P:angiogenesis; IEA:InterPro.
DR   GO; GO:0007411; P:axon guidance; IEA:InterPro.
DR   CDD; cd00041; CUB; 2.
DR   CDD; cd00057; FA58C; 2.
DR   CDD; cd06263; MAM; 1.
DR   Gene3D; 2.60.120.260; -; 2.
DR   Gene3D; 2.60.120.290; -; 2.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000859; CUB_dom.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000998; MAM_dom.
DR   InterPro; IPR014648; Neuropilin.
DR   InterPro; IPR027143; Neuropilin-2.
DR   InterPro; IPR022579; Neuropilin_C.
DR   InterPro; IPR035914; Sperma_CUB_dom_sf.
DR   PANTHER; PTHR46806:SF2; PTHR46806:SF2; 1.
DR   Pfam; PF00431; CUB; 2.
DR   Pfam; PF11980; DUF3481; 1.
DR   Pfam; PF00754; F5_F8_type_C; 2.
DR   Pfam; PF00629; MAM; 1.
DR   PIRSF; PIRSF036960; Neuropilin; 1.
DR   PRINTS; PR00020; MAMDOMAIN.
DR   SMART; SM00042; CUB; 2.
DR   SMART; SM00231; FA58C; 2.
DR   SMART; SM00137; MAM; 1.
DR   SUPFAM; SSF49785; SSF49785; 2.
DR   SUPFAM; SSF49854; SSF49854; 2.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS01180; CUB; 2.
DR   PROSITE; PS01285; FA58C_1; 2.
DR   PROSITE; PS01286; FA58C_2; 2.
DR   PROSITE; PS50022; FA58C_3; 2.
DR   PROSITE; PS50060; MAM_2; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|PIRNR:PIRNR036960, ECO:0000256|PIRSR:PIRSR036960-
KW   1}; Complete proteome {ECO:0000313|Proteomes:UP000233060};
KW   Developmental protein {ECO:0000256|PIRNR:PIRNR036960};
KW   Differentiation {ECO:0000256|PIRNR:PIRNR036960};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR036960-2, ECO:0000256|PROSITE-
KW   ProRule:PRU00059, ECO:0000256|SAAS:SAAS01008102};
KW   Membrane {ECO:0000256|PIRNR:PIRNR036960, ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR036960-1};
KW   Neurogenesis {ECO:0000256|PIRNR:PIRNR036960};
KW   Receptor {ECO:0000256|PIRNR:PIRNR036960};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL        1     22       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        23    914       Neuropilin. {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5014325858.
FT   TRANSMEM    848    873       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       28    142       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      149    220       CUB. {ECO:0000259|PROSITE:PS01180}.
FT   DOMAIN      273    423       F5/8 type C. {ECO:0000259|PROSITE:
FT                                PS50022}.
FT   DOMAIN      430    588       F5/8 type C. {ECO:0000259|PROSITE:
FT                                PS50022}.
FT   DOMAIN      640    798       MAM. {ECO:0000259|PROSITE:PS50060}.
FT   REGION      294    313       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2K5LUW1}.
FT   REGION      597    619       Disordered. {ECO:0000256|MobiDB-lite:
FT                                A0A2K5LUW1}.
FT   COMPBIAS    597    616       Polar. {ECO:0000256|MobiDB-lite:
FT                                A0A2K5LUW1}.
FT   METAL       197    197       Calcium. {ECO:0000256|PIRSR:PIRSR036960-
FT                                1}.
FT   METAL       211    211       Calcium. {ECO:0000256|PIRSR:PIRSR036960-
FT                                1}.
FT   DISULFID     28     55       {ECO:0000256|PIRSR:PIRSR036960-2,
FT                                ECO:0000256|PROSITE-ProRule:PRU00059}.
FT   DISULFID     83    105       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    149    175       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    273    423       {ECO:0000256|PIRSR:PIRSR036960-2}.
FT   DISULFID    430    588       {ECO:0000256|PIRSR:PIRSR036960-2}.
SQ   SEQUENCE   914 AA;  103204 MW;  D5E3B6598F5D9F09 CRC64;
     MDMFPLTWVF LALYFSRHQV RGQPDPPCGG RLNSKDAGYI TSPGYPQDYP SHQNCEWIVY
     APEPNQKIVL NFNPHFEIEK HDCKYDFIEI RDGDSESADL LGKHCGNIAP PTIISSGSML
     YIKFTSDYAR QGAGFSLRYE IFKTGSEDCS KNFTSPNGTI ESPGFPEKYP HNLDCTFTIL
     AKPKMEIVLQ FLIFDLEHDP LQVGEGDCKY DWLDIWDGIP HGDTPWDQTP SELRSSTVIL
     SPDLSHGHGA WPRMASLRVY YLLHQEPLEN FQCNVPLGME SGRIANEQIS ASSTYSDGRW
     TPQQSRLHGD DNGWTPNLDS NKEYLQVDLR FLTMLTAIAT QGAISRETQN GYYVKSYKLE
     VSTNGEDWMV YRHGKNHKVF QANNDATEVV LNKLHAPLLT RFVRIRPQTW HSGIALRLEL
     FGCRVTDAPC SNMLGMLSGL IADSQISASS THEYLWSPSA ARLVSSRAGW FPRIPQAQPG
     EEWLQVDLGT PKTVKGVIIQ GARGGDSITA VEARAFVRKF KVSYSLNGKD WEYIQDPRTQ
     QPKLFEGNMH YDTPDIRRFD PVPAQYVRVY PERWSPAGIG MRLEVLGCDW TDSKPTVETL
     GPTVKSEETT TPYPTDEEAT ECGENCSFED DKDLQLPSGF NCNFDFPEEP CGWMYDHAKW
     LRTTWASSSS PNDRTFPDDR NFLRLQSDSR REGQYARLIS PPVHLPRSPV CMEFQYQAMG
     GRGVALQVVR EASQESKLLW VIREDQGGEW KHGRIILPSY DMEYQIVFEG VIGKGRSGEI
     AIDDIRISTD VPLENCMVDI PEIHEREGYE DEIDDEYEVD WSNSSATSGS GAPSTDKEKS
     WLYTLDPILI TIIAMSSLGV LLGATCAGLL LYCTCSYSGL SSRSCTTLEN YNFELYDGLK
     HKVKMNHQKC CSEA
//
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