ID   A0A2K5LVW3_CERAT        Unreviewed;       484 AA.
AC   A0A2K5LVW3;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Iduronate 2-sulfatase {ECO:0000313|Ensembl:ENSCATP00000017073.1};
GN   Name=IDS {ECO:0000313|Ensembl:ENSCATP00000017073.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000017073.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000017073.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
CC         Evidence={ECO:0000256|ARBA:ARBA00001913};
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
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DR   AlphaFoldDB; A0A2K5LVW3; -.
DR   Ensembl; ENSCATT00000041237.1; ENSCATP00000017073.1; ENSCATG00000032457.1.
DR   GeneTree; ENSGT00940000156803; -.
DR   OMA; HVFTRAY; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000032457; Expressed in frontal cortex and 12 other cell types or tissues.
DR   GO; GO:0004423; F:iduronate-2-sulfatase activity; IEA:InterPro.
DR   CDD; cd16030; iduronate-2-sulfatase; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR035874; IDS.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   PANTHER; PTHR45953; IDURONATE 2-SULFATASE; 1.
DR   PANTHER; PTHR45953:SF1; IDURONATE 2-SULFATASE; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           26..484
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014429364"
FT   DOMAIN          38..415
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
SQ   SEQUENCE   484 AA;  54101 MW;  0CCAA4833F35D14E CRC64;
     MPTPGSGRGF LWLGLVLSSV CVALGCETQA NSTTDALNIL LIIVDDLRPS LGCYGDKLVR
     SPNIDQLASH SLLFQNAFAQ QAVCAPSRVS FLTGRRPDTT RLYDFNSYWR VHAGNFSTIP
     QYFKENGYVT MSVGKVFHPG ITSNHTDDSP YSWSFPPYHP SSEKYENTKT CRGPDGELHA
     NLLCPVDVVD VPEGTLPDKQ STEQAIQLLE KMKTSASPFF LAVGYHKPHI PFRYPKEFQK
     LYPLENITLA PDSEVPDGLP PVAYNPWMDI RQREDVQALN ISVPYGPIPV EFQRKIRQSY
     FASVSYLDTQ VGRLLSALDD LQLANSTIVA FTSDHGWALG EHGEWAKYSN FDVATHVPLM
     FYVPGRTASL PEAGEKLFPY LDPFDSASEL MEPGRQSMDL VELVSLFPTL AGLAGLQVPP
     RCPVPSFHVE LCREGKNLLK HFRFRDLEED PYLPDYSLRI VCQCQVVKNI SLLLLFLLSC
     CLRG
//