ID A0A2K5LW63_CERAT Unreviewed; 889 AA.
AC A0A2K5LW63;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=Leptin receptor {ECO:0000256|ARBA:ARBA00019169};
DE AltName: Full=OB receptor {ECO:0000256|ARBA:ARBA00031601};
GN Name=LEPR {ECO:0000313|Ensembl:ENSCATP00000017187.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000017187.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000017187.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004251}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane
CC {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR AlphaFoldDB; A0A2K5LW63; -.
DR Ensembl; ENSCATT00000041351.1; ENSCATP00000017187.1; ENSCATG00000032495.1.
DR GeneTree; ENSGT00730000111209; -.
DR OMA; FPPHCLF; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000032495; Expressed in liver and 9 other cell types or tissues.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004896; F:cytokine receptor activity; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 7.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR003531; Hempt_rcpt_S_F1_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR010457; IgC2-like_lig-bd.
DR InterPro; IPR041182; LEP-R_IGD.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF89; INTERLEUKIN-13 RECEPTOR SUBUNIT ALPHA-1; 1.
DR Pfam; PF06328; Lep_receptor_Ig; 1.
DR Pfam; PF18589; ObR_Ig; 2.
DR SMART; SM00060; FN3; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
DR PROSITE; PS01355; HEMATOPO_REC_S_F1; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 838..860
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 237..331
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 537..632
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 738..831
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
SQ SEQUENCE 889 AA; 101535 MW; 52510804F0F645EE CRC64;
MICQKFCVVL LHWEFICVIT AFNLSYPITP WRFKLSCMPP NSTYDYFLLP AGLSKNTSNL
NGHYETAVEF NSSDTHFSNL SKTTFHCCFR SEQDRNCSLC ADNIEGKTFV STVNSSVFQQ
MGANWNIQCW LKGDLKLFIC YVESLFKNPF KNYKHKVHLL YVLPEVLEDS PLVPQKGSFQ
MVHCNCSVHE RCECLVPVPT AKLNDTLLMC LKITSGGVIF QSPLMSVQPI NMVKPDPPLG
LRMEITDDGN LKISWSSPPL VPFPLQYEVK YSENSTTVIR EADKIVSATS LLVDGILPGS
SYEVQVRGKR LDGPGIWSDW STPHVFTTQD VIYFPPKILT SVGSNVSFHC IYKNENKIVS
SKKIVWWMNL AEKIPQSQYD VVSDHVSKVT FFNLNETKPR GKFTYDAVYC CNEHECHHRY
AELYVIDVNI NISCETDGHL TKMTCRWSTN TIQSLAGSTL QLRYRRSSLY CFDIPSIHRI
SKPKDCYLQS DGFYECVFQP IFLLSGYTMW IRINHPLGSL DSPPTCVLPD SVVKPLPPSS
VKAEIIKNIG LLKISWEKPV FPENNLQFQI RYGLSGKEIQ WKMYDVYDAK SKSVSLPVPD
LCAVYAVQVR CKRSDGLGLW SNWSNPAYTV VMDIKVPMRG PEFWRIINGD TMKKEKNVTL
LLKPLMKNDS LCSVQRYVIN HHTSCNGTWS EDVGNHTKFT FLWTEQAHTV TVLAINSIGA
SVANFNLTFS WPMSKVNIVQ SLSAYPLNSS CVILSWILSP SDYKLMYFII EWKNLNEDGE
IKWLRISSSV KKYYIHDHFI PIEKYQFSLY PIFMEGVGKP KIINSFTQDN TEKHQNDAGL
YVIVPVIISS SILLLGTLLI SHQRMKKLFW EDVPNPKNCS WAQGLNFQK
//
