ID A0A2K5LWQ6_CERAT Unreviewed; 7658 AA.
AC A0A2K5LWQ6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Nebulin {ECO:0000313|Ensembl:ENSCATP00000017385.1};
GN Name=NEB {ECO:0000313|Ensembl:ENSCATP00000017385.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000017385.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000017385.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR STRING; 9531.ENSCATP00000017385; -.
DR Ensembl; ENSCATT00000041551.1; ENSCATP00000017385.1; ENSCATG00000031600.1.
DR GeneTree; ENSGT00940000154533; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000031600; Expressed in skeletal muscle tissue and 6 other cell types or tissues.
DR GO; GO:0030018; C:Z disc; IEA:Ensembl.
DR GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR CDD; cd11933; SH3_Nebulin_C; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR013998; Nebulin-like.
DR InterPro; IPR000900; Nebulin_repeat.
DR InterPro; IPR035629; Nebulin_SH3.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR11039; NEBULIN; 1.
DR PANTHER; PTHR11039:SF37; NEBULIN; 1.
DR Pfam; PF00880; Nebulin; 112.
DR Pfam; PF14604; SH3_9; 1.
DR PRINTS; PR00510; NEBULIN.
DR SMART; SM00227; NEBU; 202.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51216; NEBULIN; 143.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 7599..7658
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 35..68
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7518..7555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7572..7596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..52
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7518..7538
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7658 AA; 886197 MW; 22C78BAEA818D238 CRC64;
GSLANAFVLY LQYYTEEVVY EEVPGETITE IYETTTTRTS DYEQSETSKP ALAQPALAQP
APAKPVERRK VIRKKVDPSK FMTPYIAHSQ KMQDLFSPNK YKEKFEKTKG RPYASTTDTP
ELRRIKKVQD QLSEVKYRID GDVAKTICHV DEKAKDIEHA KKVSQQVSKV LYKQNWEDTK
DKYLLPPDAP ELVQAVKNTA MFSKKLYTED WEADKTLFYP YNDSPELRRV AQAQKALSDV
AYKKGLAEQQ AQFTPLADPP EIEFAKKVTN QVSKQKYKED YENKIKGKWS ETPCFEVANA
RMNADNISTR KYQEDFENMK DQIYFMQTET PEYKMNKKAG VAASKVKYKE DYEKNKGKAD
YNVLPASENP LLKQLKAAGD ALSDKLYKEN YEKTKAKSIN YCETPKFKLD TVLQNFSSDK
KYKDSYLKNI LGHYVGSFED PYHSHCMRVT AQNSDKNYKA EYEEDRGKGF FPQTITQEYE
AIKKLDQCKD HTYKVHPDKT KFTQVTDSPV LLQAQVNSKQ LSDLNYKAKH ESEKFKCHIP
PDTPALIQHK VNAYNLSDNL YKQDWEKSKA KKFDIKVDAI PLLAAKANTK NTSDVMYKKD
YEKNKGKMIG ALSINDDPKM LHSLKVAKNQ SDRLYKENYE KTKAKSMNYC ETPKYQLDTQ
LKNFSEAKYK DLYVKNILGH YVGSFEDPYH THCMKVAAQN SDKSYKAEYE EDKGKCYFPQ
TITQEYEAIK KLDQCKDHTY KVHPDKTKFT AVTDTPVLLQ AQLNTKQLSD LNYKAKHEGE
KFKCHVPADA PQFIQHRVNA YNLSDNLYKQ DWEKSKAKKF DIKVDAIPLL AAKANTKNTS
DVMYKKDYEK SKGKMIGALS INDDPKMLHS LKTAKNQSDR EYRKDYEKSK TIYTAPLDML
QVTQAKKSQA IASDVDYKHI LHSYSYPPDS INVDLAKKAY ALQSDVEYKA DYNSWMKGCG
WLPFGSLEME KAKRASDILN EKKYRQHPDT LKFTSIEDAP ITVQSKINQA QRSDIAYKAK
GEEIIHKYNL PADLPQFIQA KVNAYNISEN MYKADLKDLS KKGYDLRTDA IPIRAAKAAR
QAASDVQYKK DYEKAKGKMV GFQSLQDDPK LVHYMNVAKI QSDREYKKDY EKTKTKYNTP
HDMFNVVAAK KAQDVVSNVN YKHSLHHYTY LPDAMDLELS KNMMQIQSDN VYKEDYNNWM
KGIGWIPIGS LDVEKVKKAG DALNEKKYRQ HPDTLKFTSI VDSPVMVQAK QNTKQVSDIL
YKAKGEDVKH KYTMSPDLPQ FLQAKCNAYN ISDVCYKRDW HDLIAKGNNV LGDAIPITAA
KASRNIASDY KYKEAYEKAK GKHVGFRSLQ DDPKLVHYMN VAKMQSDREY KKNYENTKTS
YHTPGDMVSI TAAKMAQDVA TNVNYKQPLH HYTYLPDALS LEHTRNVNQI QSDNVYKDEY
NSFFKGIGWI PIGSLEVEKV KKAGDALNEK KYRQHPDTIK FTSLPDSMGM VLAQHNTKQL
SDLNYKVEGE KLKHKYTIDP ELPQFIQAKV NALNMSDAHY KADWKKTIAK GYDLRPDAIP
IVAAKSSRNI ASDCKYKEAY EKAKGKQVGF RSLQDDPKLV HYMNVAKMQS DREYKKGYEA
SKTKYHTPLD MVSVTAAKKS QEVATNANYR QPYHHYTLLP DALNVEHSRN AMQIQSDNLY
KSDFTNWMKG IGWVPIESLE VEKAKKAGEI LSEKKYRQHP EKLKFTYAMD TMEQALNKSN
KLNMDKRLYT EKWNKDKTTI HVMPDTPDIL LSRVNQITMS DKLYKAGWEE EKKKGYDLRP
DAIAIKAARA SRDIASDYKY KQAYEQAKGK HIGFRSLEDD PKLVHFMQVA KMQSDREYKK
GYEKSKTSFH TPVDMLSVVA AKKSQEVATN ANYRNLIHTY NMLPDAMSFE LAKTRMQIQS
DNQYKADYAD FMKGIGWLPL GSLEAEKNKK AMEIISEKKY RQHPDTLKYS TLMDSMNMVL
AQNNAKIMNE HLYKQAWEAD KTKVHIMPDI PQIILAKANA INMSDKLYKL SLEESKKKGY
DLRPDAIPIK AAKASRDIAS DYKYKHDYEK GKGKMVGFRS LEDDPKLVHS MQVAKMQSDR
EYKKNYENTK TSYHTPADML SVTAAKDAQA NITNTNYKHL IHKYILLPDA MNIELTRNMN
RIQSDNEYKQ DYNEWYKGLG WSPAGSLEVE KAKKATEYAS DQKYRQHPSN FQFKKLTDSM
DMVLAKQNAH TMNKYLYTVD WNKDKTNVHV MPDTPDILQA KQNQTLYSQK LYKLGWEESL
KKGYDLPVDA ISVQLAKASR DIASDFKYKQ GYRKQLGHHV GFRSLQDDPK LVLSMNVAKM
QSEREYKKDF EKWKTKFSSP VDMLGVVLAK KCQELVSDVD YKNYLHQWTC LPDQNDVVQA
KKVYELQSEN LYKSDLEWLR GIGWSPLGSL EAEKNKRASE IISEKKYRQP PDRNKFTSIP
DAMDIVLAKT NAKNRSDRLY REAWDKDKTQ IHIMPDTPDI VLAKANLINT SDKLYRMGYE
ELKRKGYDLP VDAIPIKAAK ASREIASEYK YKDGYRKQLG HHIGARNIED DPKMMWSMHV
AKIQSDREYK KDFEKWKTKF SSPVDMLGVV LAKKCQTLVS DVDYKNYLHQ WTCLPDQSDV
IHARQAYDLQ SDNLYKSDLQ WLKGIGWMPS GSLEDEKNKR ATQILSDHVY RQHPDKFKFS
SLMDSIPMVL AKNNAITMNH RLYTEAWDKD KTTVHIMPDT PEVLLAKQNK VNYSEKLYKL
GLEEAKRKGY DMRVDAIPIK AAKASRDIAS EFKYKEGYRK QLGHHIGARA IHDDPKMMWS
MHVAKIQSDR EYKKDFEKWK TKFSSPVDML GVVLAKKCQT LVSDVDYKNY LHQWTCLPDQ
SDVIHARQAY DLQSDNMYKS DLQWMRGIGW VPIGSLDVEK CKRATEILSD KIYRQPPDTF
KFTSVTDSLE QVLAKNNAIT MNKRLYTEAW DKDKTQIHIM PDTPEIMLAR TNKINYSETL
YKLAHEEAKK EGYDLRSDAI PIVAAKASRD IISDYKYKDG YRKQLGHHIG ARNIEDDPKM
MWSMHVAKIQ SDREYKKDFE KWKTKFSSPV DMLGVVLAKK CQTLVSDVDY KNYLHEWTCL
PDQSDVIHAR QAYDLQSDNI YKSDLQWLRG IGWVPIGSVD VVKCKRAAEI LSDNIYRQPP
DKLKFTSVTD SLEQVLAKNN ALNMNKRLYT EAWDKDKTQI HIMPDTPEIM LARQNKINYS
ETLYKLANEE AKKKGYDLRS DAIPIVAAKA SRDIISDYKY KDGYRKQLGH HIGARNIEDD
PKMMWSMHVA KIQSDREYKK DFEKWKTKFS SPVDMLGVVL AKKCQTLVSD VDYKNYLHQW
TCLPDQNDVM HARQAYDLQS DNIYKSDLQW LRGIGWVPIG SVDVVKCKRA AEILSDNIYR
QPPDKLKFTS VTDSLEQVLA KNNALNMNKR LYTEAWDKDK TQVHIMPDTP EIMLARQNKI
NYSESLYRQA MEEAKKEGYD LRSDAIPIVA AKASRDIASD YKYKEAYRKQ LGHHIGARAV
HDDPKIMWSL HIAKVQSDRE YKKDFEKYKT RFSSPVDMLG IVLAKKCQTL VSDVDYKHPL
HEWICLPDQN DIIHARKAYD LQSDNLYKSD LEWMKGIGWV PIDSLEVLRA KRAGELLSDT
VYRQRPETLK FTSITDSPEQ VLAKNNALNM NKRLYTEAWD NDKKTIHVMP DTPEIMLAKL
NRINYSDKLY KLALEESKKE GCDLRLDAIP IQAAKASREI ASDYKYKEGY RKQLGHHIGA
RNIEDDPKML WSIHAGKIQS DREYKKDFEK WKTKFSSPVD MLGMVMAKKC QILVSDIDYR
HPLHEWMCLP DQNDVIQARK AYDLQSDAIY KSDLEWLRGI GWVPIGSVEV EKVKRAGEIL
SDRKYRQPRD QLKFTCITDT PEIVLAKNNA LTMSKHLYTE AWDADKTSIH VMPDTPEILL
AKSNSANISQ KLYTKGWDES KMKDYDLRAD AISIKSAKAS RDIASDYKYK EAYEKQKGHH
IGAQSVEDDP KIMCAIHAGK IQSEREYKKE FQKWKTKFSS PVDMLGILLA KKCQTLVSDI
DYRNYLHHWT CMPDQNDIIQ AKKAYDLQSD SVYKADLEWL RGIGWMPEGS VEMNRVKVAQ
DLLNERLYRT RPEALSFTSI VDTPEVVLAK ANSLQISEKL YQEAWNKDKS NITIPSDTPE
MLQAHINALQ ISNKLYQKDW NESKQKGYDI RADAIEIKHA KASREIASEV GFLLFSCSFS
PLQNKQEDYF SRILCLKKIC LLFLLLLFTV PSPDLLMSSL KLPKILLSNS FNYKYKEGYR
KQLGHHVGFR TLQDDPKLVW SIHAAKIQSE REYKKAYEKS KGIHNTPLDM MSIVQAKKCQ
VLVSDIDYRN YLHQWTCLPD QNDVIQAKKA YDLQSDNLYK SDLEWLKGIG WLPEGSVEVM
RVKNAQNLLN ERLYRIKPED LKFTSIVDTP EVIQAKINAV QISEPLYRDA WEKEKANVNV
PADTPLMLQS KINALQISNV RQHTSFAFQS ALCLTRPFII YPKESLAKAV WVCMCLYTVH
LNVLTLTRLR PLQIDCGIAL CFQKHYQQAW EDVKMTGYDL RADAIGIQHA KASRDIASDY
LYKTAYEKQK GHYIGCRNAK EDPKLVWAAN VLKMQNDRLY KKAYNDHKAK ISIPGDMVSI
NAAKEGQALA SDVDYRQYLH QWSCLPDQND VIQARKAYDL QSDALYKADL EWLRGIGWMP
QGSPEVLRVK NAQEIFCDSV YRTPVVNLKY TSIVDTPDVV LAKSNAENIS IPKYREVWDK
DKTSVHIMPD TPEINLARAN ALNVSNKLYR EGWDEMKAGC DVRLDAIPIQ AAKASREIAS
DYKYKLDHEK QKGHYVGTLT ARDDNKIRWA LIADKLQNER EYRLDWAKWK AKIQSPADML
SVLHSKNSQA LVSDVDYRNY LHQWTCMPDQ NDVIQAKKAY ELQSDNVYKA DLEWLRGIGW
MPNDSVSVNH AKHAADIFSE KKYRTKIETL NFTPVDDRVD YVTAKQSGEI LDDIKYRKDW
NDTKSKYTLT ETPLLHTAQE AARILDQYLY KEGWERQKAT GYILPPDAVP FVHAHHSSDV
QSELKYRADH VKQKGHYVGV PTMRDDPKLV WFEHAGQIQN ERLYKEDYHK TKAKINIPAD
MKSVLAAKEG QTLVSDIDYR NYLHQWTCHP DQNDVIQARK AYDLQSDNIY KADLEWLRGI
GWIPLDSVDH VRVTKNQEMM NQIKYKKNAL DNYPNFTSVV DPPEIVLAKI NSVNQSDVKY
KETFNKAKGK YTFSPDTPHI SHSRDMGKLY STILYKGAWE GTKAYGYTLD ERYIPIVGAK
HADLVNSELK YKETYEKQKG HYLAGKVIGE FPGVVHCLDF QQMRSALNYR KHYEDTKANV
HIPNDMMNHV LAKRCQYILS DLEYRHYFHQ WTSLPEEPNV IRVRNAQEIL SDNVYKDDLN
WLKGIGCYVW DTPQILQAKK SYDLQSQLQY TAAGKENLQN YNLVTDTPVY VTAVQSGINA
SEVKYKENYH QIKDKYTAVL ETVDSDRIRN LKNLYSSNLY KEAWDRVKAT SYILPSSTLS
LTHAKNQKHL ASHVKYREEY EKFKALYTLP RSVDDDPNTA RCLRVGKLNI DRLYRSVYEK
NKMKIHIVPD MVEMVTAKDS QKKVSEIDYR LHLHEWICHP DLKVNDHVRK VTDQISDIVY
KDDLNWLKGI GCYVWDTPEI LHAKHAYDLR DDIKYKAHML KTRNDYKLVT DTPVYVQAVK
SGKQLSDAVY HYDYVHSVRG KVAPTTKTVD LDRALHAYKL QSSVTCAPCP TGYRLPGDTP
HFKHIKDTRY MSSYFKYKEA YEHTKAYGYT LGPKDVPFVH VRRVNNVTSE RLYRELYHKL
KDKIHTTPDT PEIRQVKKTQ EAVSELIYKS DFFKMQGHMI SLPYTPQVIH CRYVGDITSD
IKYKEDLQVL KGFGCFLYDT PDMVRSRHLR KLWSNYLYTD KARKMRDKYK VVLDTPEYRK
VQELKTHLSE LVYRAAGKKQ KSIFTSVPDT PDLLRAKRGQ KLQSQYLYVE LATKERPHHH
AGNQTTALKH AKDVKDMVSE KKYKIQYEKM KDKYTPVPDT PILIRAKRAY WNASDLRYKE
TFQKTKGKYH TVKDALDIVY HRKVTDDISK IKYKENYMSQ LGIWRSIPDR PEHFHHRAVT
DAVSDVKYKE DLTWLKGIGC YAYDTPDFTL AEKNKTLYSK YKYKEVFERT KSDFKYVADC
PINRHFKYAT QLMNEKKYRA DYEQRKDKYH LVVDEPRHLL AKTAGDQISQ RKYKSSAKMF
LQHGCNEILR PDMLTALYNS HMWSQIKYRK NYEKSKDKFT SIVDTPEHLR TTKVNKQISD
ILYKLEYNKA KPRGYTTIHD TPMLLHVRKV KDEVSDLKYK EVYQRNKSNC TIEPDAVHIK
AAKDAYKVNT NLDYKKQYEA TKAHWKWTPD RPDFLQAAKS SLQQSDFEYK LDREFLKGCK
LSVTDDKNTV LALRNTLIES DLKYKEKHVK ERGTCHAVPD TPQILLAKTV SHLVSENKYK
DHVKKHLAQG SYTTLPETRD TVHVKEVTKH VSDTNYKKKF VKEKGKSNYS IMLEPPEVKH
AMEVAKKQSD VAYRKDAKEN LHYTTVADRP DIKKATQAAK QASEVEYRAK HRKEGSHGLS
MLGRPDIEMA KKAAKLSSQV KYRENFDKEK GKTPKYNPKD SQLYKVMKDA NNLASEVKYK
ADLKKLHKPV TDMKESLIMN HVLNTSQLAS SYQYKKKYEK SKGHYHTIPD NLEQLHLKEA
TELQSIVKYK EKYEKERGKP MLDFETPTYI TAKESQQMQS GKEYRKDYEE SIKGRNLTGL
EVTPALLHVK YATKIASEKE YRKDLEESIR GKGLTEMEDT PDMLRAKNAT QILNEKEYKR
DLELEVKGRG LNAMANETPD FMRARNATDI ASQIKYKQSA EMEKANFTSV VDTPEIIHAQ
QVKNLSSQKK YKEDAEKSMS YYETVLDTPE MQRVRENQKN FSLLQYQCDL KNSKGKITVV
QDTPEILRVK ENQKNFSSVL YKENLGKGIP TAITPEMERV KRNQENFSSK AYISQATPAG
SLAAVFLTDV FYRQTSCVGS IVTLFLKVIE VLHHKNNNKN TFRLIRLLVL CTQILYKENL
SKGTPLPVTP EMERVKLNQE NFSSVLYKEN VGKGIPIPIT PEMERVKHNQ ENFSSVLYKE
NLGTGIPIPI TPEMQRVKHN QENLSSVLYK ENMGKGTPLP VTPEMERVKH NQENISSVLY
KENMGKGTPL PVTPEMERVK HNQENISSVL CKEKGGRGNP LLCLRVLYKE NVGKATPTPV
TPEMQRVKRN QENISSVLVN IAFPPNFDFR AQLCISQVLY KENLGKATPT PFTPELERVK
RNQENFSSVL YSDSFRKQIQ GKAAYVLDTP EMRRVRETQR HISTVKYHED FEKHKGCFTP
VVTDPITERV KKNMQDFSDI NYRGIQRKVV EMEQKRNDQD QETITGLRVW RTNPGSVFDY
DPAEDNIQSR SLHMINVQAQ RRSREQSRSA SALSISGGEE KSEHSEAPDH HLSTYSDGGV
FAVSTAYKHA KTTELPQQRS SSVATQQTTV SSIPSHPSTA GKIFRAMYDY MAADADEVSF
KDGDAIINVQ AIDEGWMYGT VQRTGRTGML PANYVEAI
//
