ID   A0A2K5LX23_CERAT        Unreviewed;      1663 AA.
AC   A0A2K5LX23;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 26.
DE   SubName: Full=DENN domain containing 4C {ECO:0000313|Ensembl:ENSCATP00000017468.1};
GN   Name=DENND4C {ECO:0000313|Ensembl:ENSCATP00000017468.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000017468.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000017468.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
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DR   Ensembl; ENSCATT00000041635.1; ENSCATP00000017468.1; ENSCATG00000032598.1.
DR   GeneTree; ENSGT00940000158215; -.
DR   OMA; PADEICY; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000032598; Expressed in thymus and 12 other cell types or tissues.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.50.11500; -; 1.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR   InterPro; IPR001194; cDENN_dom.
DR   InterPro; IPR005112; dDENN_dom.
DR   InterPro; IPR043153; DENN_C.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR037516; Tripartite_DENN.
DR   PANTHER; PTHR12296; DENN DOMAIN-CONTAINING PROTEIN 4; 1.
DR   PANTHER; PTHR12296:SF17; DENN DOMAIN-CONTAINING PROTEIN 4C; 1.
DR   Pfam; PF03455; dDENN; 1.
DR   Pfam; PF02141; DENN; 1.
DR   SMART; SM00801; dDENN; 1.
DR   SMART; SM00799; DENN; 1.
DR   PROSITE; PS50211; DENN; 1.
PE   4: Predicted;
KW   Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   DOMAIN          1..395
FT                   /note="UDENN"
FT                   /evidence="ECO:0000259|PROSITE:PS50211"
FT   REGION          870..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1033..1092
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1173..1228
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1044..1092
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1173..1197
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1663 AA;  185746 MW;  30A190143ADA52F4 CRC64;
     RLSLPKCWDC RPKIENVLKK FNKTAAIQFY EPYSRELLSE KQLMQLGLLT PVERKMVSKS
     INTNKCICLL SHWPFFDAFR KFLMFIYKLS VSGPHPLPIE KHISHFMQNI PFPSPQRPRI
     LVQLSVHDAL ILSQPVSTPL PLSGANFSTL LMNLGPENCA TLLLFVLLES KILLHSLRPA
     VLTGVAEAVV AMIFPFQWQC PYIPLCPLSL AAVLSAPLPF IVGVDSRYFD LHDPPQDVVC
     IDLDTNMLYV SDEKKNMNWK QLPKKPCKNL LSTLKKLYPQ LSSVHRKTQE GSAIDMTPIE
     ADFSWQKKMT QLEMEIQEAF LRFMASILKG YRTFLRPITE APSNKATAAD SLFDRQGFLK
     SRDRAYAKFY TLLSKTQIFI RFIEECSFVS DKDTGLAFFD DCIEKLFPDK GTEKSDKVDF
     DSAEDTRLIE LDDSQKSEHT VFIMPPEPPP DDGKDLSPKY SYKYFPRLDL KLFDRPQELK
     LCFSRHPTGS SITKSPALMA KRTKQEIKTA HKLAKRCYTN PSQWAKCLFS HCYSLWFICL
     PAYVRVSHPK VRALQQAYDV LIKMRKTDVD PLDEVCYRVV MQLCGLWGHP VLAVRVLFEM
     KTARIKPNAI TYGYYNKVVL ESPWPSSTRS GIFLWTKVRN VVHGLAQFRQ PLKKTVQRSQ
     VSSISGGQSD QGYGSKDELI KDDAEIHVPE EQATRELITK TKMQTEEVCD ASAIVAKHSQ
     PSPEPHSPTE SPAWGSSIVK VPSGIFDINS RKSSTGSISN VLVSTQDPVE DAVFGEATNL
     KKNGDRGEKR QKHFPERSCS FSSESRAGML LKKSSLDSNS SEMAIMMGAD AKILTAALTC
     PKTSPLHIAR THTFENVSCH LPDSRTCVSE STWNPEYRSS PVPEMLEESQ ELLEPVTDDI
     PKTTATEDTY ESLLSDSNSN QSRDLKTGSK DLRNKRSSLY GIAKEVERED VETGLDPLSL
     LATECSGGET LDSEDKLFSP VIARNLADEI ESYMNLKSPL GSKSSSMELH GEENRESGMT
     TAFIHALERR SSLPLDHGSP AQENPESEKS SPAVSRSKTF TGRFKQQTPS RTHKERSTSL
     SALIRSSPHG SLGSVVNSLS GLKLDNILSG PKIDVLKSGM KQAATVASKM WVAVASAYSY
     SDDEEETNRD YSFPAGLEDH ILGENISPNT SISGLVPSEL TQSNTSLGSS SSSGDVGKLH
     YPTGEVPFPR GMKGQDFEKS DHGSSQNTSM SSIYQNCAME VLMSSCSQCR ACGTLVYDEE
     IMAGWTADDS NLNTACPFCK SNFLPLLNIE FKDLRGSASF FLKPSTSGDS LQSGSIPLAN
     ESLEHKPVSS LAEPDLINFM DSPKHNQTIT EETGSAVEPS DEIKRASGDV QTMKISSVPN
     SLSKRNVSLT RSHSVGGPLQ NIDFTQRPFH GISTVSLPNS LQEVVDPLGK RPNPPPVSVP
     YLSPLVLRKE LESLLENEGD QVIHTSSFIN QHPIIFWNLV WYFRRLDLPS NLPGLILTSE
     HCNEGVQLPL SSLSQDSKLV YIQLLWDNIN LHQEPREPLY VSWRNFNSEK KSSLLSEEQQ
     ATSTLVETIR QSIQHNNVLK PINLLSQQMK PGMKRQRSLY REILFLSLVS LGRENIDIEA
     FDNEYGIAYN SLSSEILEKL QKIDAPPSAS VEWCRKCFGA PLI
//