ID A0A2K5LXE6_CERAT Unreviewed; 495 AA.
AC A0A2K5LXE6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 26.
DE SubName: Full=Src homology 2 domain containing E {ECO:0000313|Ensembl:ENSCATP00000017615.1};
GN Name=SHE {ECO:0000313|Ensembl:ENSCATP00000017615.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000017615.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000017615.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011932107.1; XM_012076717.1.
DR AlphaFoldDB; A0A2K5LXE6; -.
DR STRING; 9531.ENSCATP00000017615; -.
DR Ensembl; ENSCATT00000041782.1; ENSCATP00000017615.1; ENSCATG00000032686.1.
DR GeneID; 105593496; -.
DR KEGG; caty:105593496; -.
DR CTD; 126669; -.
DR GeneTree; ENSGT00940000159107; -.
DR OMA; CKTETVI; -.
DR OrthoDB; 2963819at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000032686; Expressed in spleen and 10 other cell types or tissues.
DR CDD; cd10391; SH2_SHE; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR035042; SHE_SH2.
DR PANTHER; PTHR15127; HEAVYWEIGHT, ISOFORM A; 1.
DR PANTHER; PTHR15127:SF29; SH2 DOMAIN-CONTAINING ADAPTER PROTEIN E; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..495
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014356040"
FT DOMAIN 395..490
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 52..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 257..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..184
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 205..227
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 495 AA; 53869 MW; EAF7366D7BA7D677 CRC64;
MQWPPTPGAS ACLGWASSLA SSTAATLLGR AGPGPLMAAK WFKEFPLNLK TVSERAKPGG
GGGKLRKNSE AGGAGPGPGK GRKNSAAELG SGRAGVGPKD SRLSRDSLQG LIQAAAGKGR
KNSRATEEEP HRGATKSSGC STYINRLIKV DTQEKNGKSN YPSSSSSSSS SSSSASSSPS
SLGPELDKSK IIKQQDTVII LEDYADPYDA KRTKGQRDAE RVGENDGYME PYDAQQMITE
IRRRGSKDPL VKALQLLDSP CEPAEGGLKS ETLAKRRSSK DLLGKPPQLY DTPYEPAEGG
PRAEGKARPP DSRLPENDER PAVEYEQPWE WKKEQIVRAL SVQFEGAERP SVREETVRQH
HRQKSWTQKI LKPALSDHSE GEKVDPGLPL EKQPWYHGAI SRAEAESRLQ PCKEAGYLVR
NSESGNSRYS IALKTSQGCV HIIVAQTKDN KYTLNQTSAV FDSIPEVVHY YSNEKLPFKG
AEHMTLLYPV HSKLH
//
