GenomeNet

Database: UniProt
Entry: A0A2K5LXS9_CERAT
LinkDB: A0A2K5LXS9_CERAT
Original site: A0A2K5LXS9_CERAT 
ID   A0A2K5LXS9_CERAT        Unreviewed;      4822 AA.
AC   A0A2K5LXS9;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   05-DEC-2018, entry version 7.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSCATP00000017749};
GN   Name=RYR3 {ECO:0000313|Ensembl:ENSCATP00000017749};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000017749, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000017749, ECO:0000313|Proteomes:UP000233060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
RA   Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
RA   Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M.,
RA   Gross S., Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V.,
RA   Khan Z., Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G.,
RA   Ongeri F., Osuji N., Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R.,
RA   Reid J.G., Santibanez J., Scheel M., Sexton D., Shah N., Skinner E.,
RA   Vee V., Wu Y., Han Y., Muzny D.M., Richards S., Worley K.C.,
RA   Rogers J., Gibbs R.A.;
RT   "Sooty reference genome and diversity panel.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCATP00000017749}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   Ensembl; ENSCATT00000041918; ENSCATP00000017749; ENSCATG00000031383.
DR   GeneTree; ENSGT00940000155507; -.
DR   Proteomes; UP000233060; Whole Genome Shotgun Assembly.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 2.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000233060};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4165   4182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4370   4390       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4438   4457       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4569   4587       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4630   4651       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4710   4733       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      212    266       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      272    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      340    397       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      582    793       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1237   1449       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3878   3913       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      456    476       {ECO:0000256|SAM:Coils}.
FT   COILED     3201   3221       {ECO:0000256|SAM:Coils}.
FT   COILED     4292   4319       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4822 AA;  546514 MW;  2E2A45FFDA2E2F21 CRC64;
     MFPILTFGSL FSPQEDEVVL QCIATIHKEQ RKFCLAAEGL GNRLCFLEPT SEAKYIPPDL
     CVCNFVLEQS LSVRALQEML ANTGENGGEG AAQGGGHRTL LYGHAILLRH SFSGMYLTCL
     TTSRSQTDKL AFDVGLREHA TGEACWWTIH PASKQRSEGE KVRIGDDLIL VSVSSERYLH
     LSVSNGNIQV DASFMQTLWN VHPTCSGSSI EEGYLLGGHV VRLFHGHDEC LTIPSTDQND
     SQHRRIFYEA GGAGTRARSL WRVEPLRISW SGSNIRWGQA FRLRHLTTGH YLALTEDQGL
     ILQDRAKADT KSTAFSFRAS KELKEKLDSS HKRDIEGMGV PEIKYGDSVC FVQHIASGLW
     VTYKAQDAKT SRLGPLKRKV ILHQEGHMDD GLTLQRCQRE ESQAARIIRN TTALFSQFVS
     GNNRTAAPIT LPIEEVLQTL QDLIAYFQPP EEEMRHEDKQ NKLRSLKNRQ NLFKEEGMLA
     LVLNCIDRLN IYNSVAHFAG IAREESGMAW KEILNLLYKL LAALIRGNRN NCAQFSNNLD
     WLISKLDRLE SSSGILEVLH CILTESPEAL NLIAEGHIKS IISLLDKHGR NHKVLDILCS
     LCLCNGVAVR ANQNLICDNL LPRRNLLLQT RLINDVTSIR PNIFLGVAEG SAQYKKWYFE
     LIIDQVDPFL TAEPTHLRVG WASSSGYAPY PGGGEGWGGN GVGDDLYSYG FDGLHLWSGR
     IPRAVASINQ HLLRSDDVVS CCLDLGVPSI SFRINGQPVQ GMFENFNTDG LFFPVMSFSA
     GVKVRFLMGG RHGEFKFLPP SGYAPCYEAL LPKEKMRLEP VKEYKRDADG VRDLLGTTQF
     LSQASFIPCP IDTSQVVLPP HLEKIRDRLA ENIHELWGMN KIELGWTFGK IRDDNKRQHP
     CLVEFSKLPE TEKNYNLQMS TETLKTLLAL GCHIAHVNPA AEEDLKKVKL PKNYMMSNGY
     KPAPLDLSDV KLLPPQEILV DKLAENAHNV WAKDRIKQGW TYGIQQDLKN KRNPRLVPYA
     LLDERTKKSN RDSLREAVRT FVGYGYNIEP SDQELADSAV EKVSIDKIRF FRVERSYAVR
     SGKWYFEFEV VTGGDMRVGW ARPGCRPDPL CLKAAGASVG IKEVGILGDV VGCMINLDDA
     SMIFTLNGEL LITNKGSELA FADYEIGNGF VPICCLGLSQ IGRMNLGTDA STFKFYTMCG
     LQEGFEPFAV NMNRDVAMWF SKRLPTFVNV PKDHPHIEVM RIDGTMDSPP CLKVTHKTFG
     TQHSNADMIY CRLSMPVECH SSFSHSPCLD SEAFQKRKQM QEILSHTTTQ CYYAIRIFAG
     QDPSCVWVGW VTPDYHLYSE KFDLNKNCTV TVTLGDERGR VHESVKRSNC YMVWGGDIVA
     SSQRSNRSNV DLEIGCLVDL AMGMLSFSAN GKELGTCYQV EPNTKVFPAV FLQPTSTSLF
     QFELGKLKNA MPLSAAIFKS EEKNPVPQCP PRLDVQTIQP VLWSRMPNSF LKVESERVSE
     RHGWVVQCLE PLQMMALHIP EENRCVDILE LCEQEDLMRF HYHTLRLYSA VCALGNSRVA
     YALCSHVDLS QLFYAIDNKY LPGLLRAGFY DLLISIHLAN AKERKLMMKN EYIIPITSTT
     RNIRLFPDES KRHGLPGVGL RTCLKPGFRF STPCFVATGE EHQKQSPEIP LESLRTKALS
     MLTEAVQCSG AHIRDPVGGS VEFQFVPVLK LIGTLLVMGV FDDDDVRQIL LLIDPSVFGE
     HSADTEEGTE KEEVTQVEEK AVEAGEKAGK EAPVKGLLQT RLPESVKLQM CELLSYLCDC
     ELQHRVEAIV AFGDIYVSKL QANQKFRYNE LMQALNMSAA LTARKTKEFR SPPQEQINML
     LNFQLGENCP CPEEIREELY DFHEDLLLHC GVPLEEEEEE EEDTSWTGKL RALVYKIKGP
     PKPEKEQPTE EEERCPTTLK ELISQTMICW AQEDQIQDAE LVRMMFNLLR RQYDSIGELL
     QALRKTYTIS HASVSDTINL LAALGQIRSL LSVRMGKEEE LLMINGLGEI MNNKVFYQHP
     NLMRVLGMHE TVMEVMVNVL STEKSQIAFP KMVASCCRFL CYFCRISRQN QKAMFEHLSY
     LLENSSVGLA SPSMRGSTPL DVAASSVMDN NELALGLEEP DLEKVVTYLA GCGLQSCPML
     LAKGYPDVGW NPIEGERYLS FLRFAVFVNS ESVEENASVV VKLLIRRPEC FGPALRGEGG
     NGLLAAMQGA IKISENPALD LPSQGYKREV TEADEEEEEI VHMGNAIMSF YSALIDLLGR
     CAPEMHLIQT GKGEAIRIRS ILRSLVPTED LVGIISIPLK LLKQQSPNGS VSEPDMAANF
     CPDHKAPMVL FLDRVYGIKD QTFLLHLLEV GFLPDLRASA SLDTVSLSTT EAALALNRYI
     CSAVLPLLTR CAPLFAGTEH CTSLIDSTLQ TIYRLSKGRS LTKAQRDTIE ECLLAICNHL
     RPSMLQQLLR RLVFDVPQLN EYCKMPLKLL TNHYEQCWKY YCLPSGWGSY GLAVEEELHL
     TEKLFWGIFD SLSHKKYDPD LFRMALPCLS AIAGALPPDY LDTRITATLE KQISVDADGN
     FDPKPINTVN FSLPEKLEYI VTKYAEHSHD KWACDKSQSG WKYGISLDEN VKTHPLIRPF
     KTLTEKEKEI YRWPARESLK TMLAVGWTVE RTKEGEALVQ QRENEKLRSV SQRSSYEASL
     PAYFLFDLAL LGGTQGMVEV VAENYHNIWA KKKKLELESK GGGSHPLLVP YDTLTAKEKF
     KDREKAQDLF KFLQVNGVIV SRGVKDMELD ASSMEKRFAY KFLKKILKYV DSAQEFIAHL
     EAIVSSGKTE KSPHDQEIKF FAKVLLPLVD QYFTNHRLYF LSSPLKPLSS SGYASHKEKE
     MVASLFCKLA ALVRHRISLF GSDSTTMVSC LHILAQTLDT RTVMKSGSEL VKAGLRAFFE
     NAAEDLEKTS ENLKLGKFTH SRTQIKGVSQ NINYTTVALL PILTSIFEHV AQHQFGMDLL
     LGDVQISCYH ILCSLYSLGT GKNIYVERQR PALGECVASL AAAIPVAFLE PTLNRYNPLS
     VFNTKTPRER SILGIPDTVE DMCPDIPQLE GLMKEINDLA ESGARYTEMP HVIEVILPML
     CNYLSYWWER GPENLPPSTG QCCTKVTSEH LSLILGNILK IINNNLGIDE ASWMKRIAVY
     AQPIISKARP DLLRSHFIPT LEKLKKKAVK TVQEEEQLRA DGKGDTQEAE LLILDEFAVL
     CRDLYAFYPM LIRYVDNNRS NWLKSPDADS DQLFRMVAEV FILWWLWLVF YGYLIRLCST
     HSFHCPLKWP QGGRLPLTGG QDQERKKTKR RGDLYSIQTS LIVAALKKML PIGLNMCTPG
     DQELISLAKS RYGHRDTDEE VREHLRNNLH LQEKSDDPAV KWQLNLYKDV LKSEEPFNPE
     KTVERVQRIS AAVFHLEQVE QPLRSKKAVW HKLLSKQRKR AVVACFRMAP LYNLPRHRSI
     NLFLHGYQRF WIETEEYSFE EKLVQDLAKS PKVEEEEEEE TEKQPDPLHQ IILYFSRNAL
     TERSKLEDDP LYTSYSSMMA KVHPEKEMEK QKTLYQQARL HERGAAEMVL QMISASKGEM
     SPMVVETLKL GIAILNGGNA GVQQKMLDYL KEKKDAGFFQ SLSGLMQSCS VLDLNAFERQ
     NKAEGLGMVT EEGTLIVRER GKFQFLNDEF TRDLFRFLQL LCEGHNSDFQ NFLRTQMGNT
     TTVNVIISTV DYLLRLQESI SDFYWYYSGK DIIDESGQHN FSKALAVTKQ IFNSLTEYIQ
     GPCIGNQQSL AHSRLWDAVV GFLHVFANMQ MKLSQDSSQI ELLKELLDLL QDMVVMLLSL
     LEGNVVNGTI GKQMVDTLVE SSTNVEMILK FFDMFLKLKD LTSSDTFKEY DPDGKGIISK
     REFQKAMEGQ KQYTQSEIDF LLSCAEADEN DMFNYIDFVD RFHEPAKDIG FNVAVLLTNL
     SEHMPNDSRL KCLLDPAESV LNYFEPYLGR IEIMGGAKKI ERVYFEISES SRTQWEKPQV
     KESKRQFIFD VVNEGGEQEK MELFVNFCED TIFEMQLASQ ISESDSADRP EEEEEDEDSS
     YVLEMAGEEE EDGSFEPASA FAMACASVKR NVADFLKRAT LKNLRKQYRN VKKMTAKELV
     KVLCSFFWML FLGLFQMLFT ILGGIFQILW STVFGGGLVE GAKNIRVTKI LGDMPDPTQF
     GIHDDTMEAE RAEVMEPGIT TELVHFIKGE KGDTDIMSDL FGLHPKKEGS LKHGPEVGLG
     DLSEIIGKDE PPTLESTVQK KRKAQAAEMK AANEAEGKVE SEKADMEDGE KEDKAKEEEQ
     AEYLWTEVTK KKKRRCGQKA EKPEAFTANF FKGLDIYQTK LLHYLARNFY NLRFLALFVA
     FAINFILLFY KVTEEPLEEE TEDVANLWNS FNDEEEEEAM VFFVLQESTG YMAPTLRALA
     IIHTIISLVC VVGYYCLKVP LVVFKREKEI ARKLEFDGLY ITEQPSEDDI KGQWDRLVIN
     TPSFPNNYWD KFVKRKVINK YGDLYGAERI AELLGLDKNA LDFSPVEETK AEAASLVSWL
     SSIDMKYHIW KLGVVFTDNS FLYLAWYTTM SVLGHYNNFF FAAHLLDIAM GFKTLRTILS
     SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF FRKFYNKSED DDEPDMKCDD MMTCYLFHMY
     VGVRAGGGIG DEIEDPAGDP YEMYRIVFDI TFFFFVIVIL LAIIQGLIID AFGELRDQQE
     QVREDMETKC FICGIGNDYF DTTPHGFETH TLQEHNLANY LNKHPLFPLF QESYVWKMYQ
     ERCWDFFPAG DCFRKQYEDQ LG
//
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