ID A0A2K5LY11_CERAT Unreviewed; 923 AA.
AC A0A2K5LY11;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=Vacuolar protein sorting-associated protein 11 homolog {ECO:0000256|PIRNR:PIRNR007860};
GN Name=VPS11 {ECO:0000313|Ensembl:ENSCATP00000017829.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000017829.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000017829.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in vesicle-mediated protein trafficking to
CC lysosomal compartments including the endocytic membrane transport and
CC autophagic pathways. Believed to act as a core component of the
CC putative HOPS and CORVET endosomal tethering complexes.
CC {ECO:0000256|PIRNR:PIRNR007860}.
CC -!- SUBCELLULAR LOCATION: Late endosome membrane
CC {ECO:0000256|PIRNR:PIRNR007860}; Peripheral membrane protein
CC {ECO:0000256|PIRNR:PIRNR007860}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR007860}. Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00004630, ECO:0000256|PIRNR:PIRNR007860};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004630,
CC ECO:0000256|PIRNR:PIRNR007860}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004630, ECO:0000256|PIRNR:PIRNR007860}.
CC Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR007860}. Early endosome
CC {ECO:0000256|PIRNR:PIRNR007860}. Cytoplasmic vesicle, autophagosome
CC {ECO:0000256|PIRNR:PIRNR007860}. Cytoplasmic vesicle, clathrin-coated
CC vesicle {ECO:0000256|PIRNR:PIRNR007860}.
CC -!- SIMILARITY: Belongs to the VPS11 family.
CC {ECO:0000256|ARBA:ARBA00007070, ECO:0000256|PIRNR:PIRNR007860}.
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DR AlphaFoldDB; A0A2K5LY11; -.
DR Ensembl; ENSCATT00000041998.1; ENSCATP00000017829.1; ENSCATG00000032706.1.
DR GeneTree; ENSGT00940000153635; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000032706; Expressed in pituitary gland and 12 other cell types or tissues.
DR GO; GO:0005776; C:autophagosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0033263; C:CORVET complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0030897; C:HOPS complex; IEA:UniProtKB-UniRule.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd16688; RING-H2_Vps11; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR016528; VPS11.
DR InterPro; IPR024763; VPS11_C.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF24; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 11 HOMOLOG; 1.
DR Pfam; PF00637; Clathrin; 1.
DR Pfam; PF12451; VPS11_C; 1.
DR Pfam; PF13923; zf-C3HC4_2; 1.
DR PIRSF; PIRSF007860; VPS11; 2.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50236; CHCR; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Autophagy {ECO:0000256|PIRNR:PIRNR007860};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR007860};
KW Endosome {ECO:0000256|PIRNR:PIRNR007860};
KW Lysosome {ECO:0000256|PIRNR:PIRNR007860};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR007860};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Protein transport {ECO:0000256|PIRNR:PIRNR007860};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transport {ECO:0000256|PIRNR:PIRNR007860};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 804..842
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 761..795
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 923 AA; 106420 MW; 9C23D1F4A085B174 CRC64;
MKSVCWRGQC RVPLSFSWSS RVKEVHFLTC YQLSNPGRFL DYPAHMEGQI WFLPRSLQLT
GFQAYKLRVT HLYQLKQHNI LASVGEDEEG INPLVKIWNL EKRDGGNPLC TRIFPAIPGT
EPTVVSCLTV HENLNFMAIG FTDGSVTLNK GDITRDRHSK TQILHKGNYP VTGLAFRQAG
KTTHLFVVTT ENVQSYIVSG KDYPRVELDT HGCGLRCSAL SDPSQDLQFI VAGDECVYLY
QPDERGPCFA FEGHKLIAHW FRGYLVIVSR DRKVSPKSEF TSRDSQSSDK QILNIYDLCN
KFIAYSAVFE DVVDVLAEWG SLYVLTRDGR VHALQEKDTQ TKLEMLFKKN LFEMAINLAK
SQHLDSDGLA QIFMQYGDHL YSKGNHDGAV QQYIRTIGKL EPSYVIRKFL DAQRIHNLTA
YLQTLHRQSL ANADHTTLLL NCYTKLKDSS KLEEFIKTKS ESEVHFDVET AIKVLRQAGY
YSHALYLAEN HAHHEWYLKI QLEDIKNYQE ALRYIGKLPF EQAESNMKRY GKILMHHIPE
QTTQLLKGLC TDYRPSLEGR SDREAPGCRA NSEEFIPIFA NNPRELKAFL EHMSEVQPDS
PQGIYDTLLE LRLQNWAHEK DPQVKEKLHA EAISLLKSGR FCDVFDKALV LCQMHDFQDG
VLYLYEQGKL FQQIMHYHMQ HEQYRQVITV CERHGEQDPS LWEQALSYFA RKEEDCKEYV
AAVLKHIENK NLMPPLLVVQ TLAHNSTATL SVIRDYLVQK LQKQSQQIAQ DELQVRRYRE
ETTRIRQEIQ ELKASPKIFQ KTKCSICNSA LELPSVHFLC GHSFHQHCFE SYSESDADCP
TCLPENRKVM DMIRAQEQKR DLHDQFQHQL KCSNDSFSVI ADYFGRGVFN KLTLLTDPPT
ARLTSSLEAG LQRDLLMHSR RGT
//