ID A0A2K5LYP3_CERAT Unreviewed; 329 AA.
AC A0A2K5LYP3;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE SubName: Full=Junctional adhesion molecule 3 {ECO:0000313|Ensembl:ENSCATP00000018067.1};
GN Name=JAM3 {ECO:0000313|Ensembl:ENSCATP00000018067.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000018067.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000018067.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
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DR RefSeq; XP_011888566.1; XM_012033176.1.
DR AlphaFoldDB; A0A2K5LYP3; -.
DR SMR; A0A2K5LYP3; -.
DR STRING; 9531.ENSCATP00000018067; -.
DR Ensembl; ENSCATT00000042240.1; ENSCATP00000018067.1; ENSCATG00000032901.1.
DR GeneID; 105573536; -.
DR KEGG; caty:105573536; -.
DR CTD; 83700; -.
DR GeneTree; ENSGT00940000156937; -.
DR OMA; ELSCIIM; -.
DR OrthoDB; 3019723at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000032901; Expressed in thymus and 12 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:Ensembl.
DR GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR GO; GO:0030057; C:desmosome; IEA:Ensembl.
DR GO; GO:0005615; C:extracellular space; IEA:Ensembl.
DR GO; GO:0031941; C:filamentous actin; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005902; C:microvillus; IEA:Ensembl.
DR GO; GO:0033010; C:paranodal junction; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0098636; C:protein complex involved in cell adhesion; IEA:Ensembl.
DR GO; GO:0043220; C:Schmidt-Lanterman incisure; IEA:Ensembl.
DR GO; GO:0098632; F:cell-cell adhesion mediator activity; IEA:Ensembl.
DR GO; GO:0005178; F:integrin binding; IEA:Ensembl.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:InterPro.
DR GO; GO:0002250; P:adaptive immune response; IEA:Ensembl.
DR GO; GO:0034333; P:adherens junction assembly; IEA:Ensembl.
DR GO; GO:0001525; P:angiogenesis; IEA:Ensembl.
DR GO; GO:0045176; P:apical protein localization; IEA:Ensembl.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:Ensembl.
DR GO; GO:0030010; P:establishment of cell polarity; IEA:Ensembl.
DR GO; GO:0097530; P:granulocyte migration; IEA:Ensembl.
DR GO; GO:0097241; P:hematopoietic stem cell migration to bone marrow; IEA:Ensembl.
DR GO; GO:0034113; P:heterotypic cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0002523; P:leukocyte migration involved in inflammatory response; IEA:Ensembl.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0002318; P:myeloid progenitor cell differentiation; IEA:Ensembl.
DR GO; GO:0033629; P:negative regulation of cell adhesion mediated by integrin; IEA:Ensembl.
DR GO; GO:0033624; P:negative regulation of integrin activation; IEA:Ensembl.
DR GO; GO:0001780; P:neutrophil homeostasis; IEA:Ensembl.
DR GO; GO:1905710; P:positive regulation of membrane permeability; IEA:Ensembl.
DR GO; GO:2000439; P:positive regulation of monocyte extravasation; IEA:Ensembl.
DR GO; GO:1902414; P:protein localization to cell junction; IEA:Ensembl.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0090138; P:regulation of actin cytoskeleton organization by cell-cell adhesion; IEA:Ensembl.
DR GO; GO:0090022; P:regulation of neutrophil chemotaxis; IEA:Ensembl.
DR GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR GO; GO:0019226; P:transmission of nerve impulse; IEA:Ensembl.
DR CDD; cd20946; IgV_1_JAM1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 2.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR042974; JAM-C.
DR PANTHER; PTHR44598; JUNCTIONAL ADHESION MOLECULE C; 1.
DR PANTHER; PTHR44598:SF2; JUNCTIONAL ADHESION MOLECULE C; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF07686; V-set; 1.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00406; IGv; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50835; IG_LIKE; 2.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 261..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 35..146
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 158..255
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 329 AA; 37011 MW; 7559C1394A171C7F CRC64;
MRGDYKLRRA AAGPSAPLDM ALRRPPRLRL CARLPDFVLL LLFRGCLIGA VNLKSSNRTP
VVQEFESVEL SCIITDSQTS DPRIEWKKIQ DDQTTYVFFD NKIQGDLAGR AEILGKTSLK
IWNVTRRDSA LYRCEVVARN DRKEIDEIVI ELTVQVKPVT PVCRVPKAVP VGKMATLYCQ
ESEGHPRPHY SWYRNDVPLP TDSRANPRFR NSSFHLNSET GTLVFTAVHK DDSGQYYCIA
SNDAGSARCE EQEMEVYDLN IGGIIGGVLV VLAVLALITL GICCAYRRGY FINNKQDGES
YKNPGKPDGV NYIRTDEEGD FRHKSSFVI
//
