ID A0A2K5M0C6_CERAT Unreviewed; 987 AA.
AC A0A2K5M0C6;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE SubName: Full=Sortilin related VPS10 domain containing receptor 2 {ECO:0000313|Ensembl:ENSCATP00000018644.1};
GN Name=SORCS2 {ECO:0000313|Ensembl:ENSCATP00000018644.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000018644.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000018644.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS10-related sortilin family. SORCS
CC subfamily. {ECO:0000256|ARBA:ARBA00010818}.
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DR AlphaFoldDB; A0A2K5M0C6; -.
DR Ensembl; ENSCATT00000042822.1; ENSCATP00000018644.1; ENSCATG00000033134.1.
DR GeneTree; ENSGT01030000234563; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000033134; Expressed in frontal cortex and 3 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR Gene3D; 2.10.70.80; -; 1.
DR Gene3D; 3.30.60.270; -; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR022409; PKD/Chitinase_dom.
DR InterPro; IPR000601; PKD_dom.
DR InterPro; IPR035986; PKD_dom_sf.
DR InterPro; IPR031777; Sortilin_C.
DR InterPro; IPR031778; Sortilin_N.
DR InterPro; IPR006581; VPS10.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR PANTHER; PTHR12106:SF9; VPS10 DOMAIN-CONTAINING RECEPTOR SORCS2; 1.
DR Pfam; PF18911; PKD_4; 1.
DR Pfam; PF15902; Sortilin-Vps10; 1.
DR Pfam; PF15901; Sortilin_C; 1.
DR SMART; SM00089; PKD; 1.
DR SMART; SM00602; VPS10; 1.
DR SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 1.
DR SUPFAM; SSF49299; PKD domain; 1.
DR PROSITE; PS50093; PKD; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 907..928
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 644..704
FT /note="PKD"
FT /evidence="ECO:0000259|PROSITE:PS50093"
SQ SEQUENCE 987 AA; 110552 MW; BFD17127E539A6B2 CRC64;
MGKVLESSLW RSSDFGTSYT KLTLQPGVTT VIDNFYICPT NKRKVILVSS SLSDRDQSLF
LSVDEGATFQ KQPIPFFVDT LIFHPKEEDK VLAYTKESKL YVSSDLGKKW TLLQERVTKD
HVFWAVSGVD ADPDLVHMEA QDLGGGFRYV TCPIHNCSEK LLAAPFAGPI DHGSLTVQDD
YIFFKVTSAN RTKYYVSYRR NEFVLMKLPK YALPKDLQII STDESQVFVA VQEWYQMDTY
NLYQSDPRGV RYALVLQDVR SSRQAEESVL IDILEVRGVK GVFLANQKID GKVMTLITYN
KGRDWDYLRP PSMDMNGKPT NCKPPDCHLH LHLRWADNPY VSGTVHTKDT APGLIMGAGN
LGSQLVEYKE EMYITSDCGH TWRQVFEEEH HILYLDHGGV IVAIKDTSIP LKILKFSVDE
GLTWSTHNFT STSVFVDGLL SEPGDETLVM TVFGHISFRS DWELVKVDFR PSFSRQCGEE
DYSSWDLSNL QGDRCIMGQQ RSFRKRKSTS WCIKGRSFTS ALTSRVCECR DSDFLCDYGF
ERSPSSESNT NKCSANFWFN PLSPPDDCAL GQTYTSSLGY RKVVSNVCEG GVDLQQSPAQ
LQCPLTPPRG LQVSIQGEAV AVRPGEDVLF VVRQEQGDVL TTKYQVDLGD GFKAMYVNLT
LTGEPIRHRY ESPGIYRVSV RAENTAGHDE AVLFVQVNSP LQALYLEVVP VIGINQEVNL
TAVLLPLNPN LTVFYWWIGH NLQPLLSLDN SVTTRFSDTG DVRVTVQAAC GNSVLQDSRV
LRVLDQFQVV PLQFSKELDA YNPNTPEWRE DVGLVVTRLL SKETSVPQEL LVTVLKPGLP
TLADLYVLLP PPRPTRKRSL SSDKRLAAIQ QVLNAQKISF LLRGGVRVLV ALRDTGTGAE
QLGGGGGYWA VVVLFVIGLF AAGAFILYKF KRKRPGRTVY AQMHNEKEQE MTSPVSHSED
VQGTAPGNHS GVVLSINSRE MHSYLVS
//
