ID   A0A2K5M1V7_CERAT        Unreviewed;       503 AA.
AC   A0A2K5M1V7;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 24.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   Name=RNF19B {ECO:0000313|Ensembl:ENSCATP00000019173.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000019173.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000019173.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR   AlphaFoldDB; A0A2K5M1V7; -.
DR   Ensembl; ENSCATT00000043354.1; ENSCATP00000019173.1; ENSCATG00000033356.1.
DR   GeneTree; ENSGT00940000158451; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000033356; Expressed in lung and 12 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20363; BRcat-RBR_RNF19B; 1.
DR   CDD; cd20355; Rcat_RBR_RNF19; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 2.20.25.20; -; 1.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   PANTHER; PTHR11685:SF109; E3 UBIQUITIN-PROTEIN LIGASE RNF19B; 1.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF01485; IBR; 2.
DR   SMART; SM00647; IBR; 2.
DR   SUPFAM; SSF57850; RING/U-box; 2.
DR   PROSITE; PS51873; TRIAD; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT   TRANSMEM        162..195
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        215..248
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          1..152
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   REGION          389..414
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          429..503
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        445..486
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   503 AA;  53771 MW;  B6A7BD3FF454B6C6 CRC64;
     MHKYEEFMLR RYLASDPDCR WCPAPDCGYA VIAYGCASCP KLTCEREGCQ TEFCYHCKQI
     WHPNQTCDMA RQQRAQSLRV RTKHTSGLSY GQESGPDDIK PCPRCSAYII KMNDGSCNHM
     TCAVCGCEFC WLCMKEISDL HYLSPSGCTF WGKKPWSRKK KILWQLGTLI GAPVGISLIA
     GIAIPAMVIG IPVYVGRKIH SRYEGRKTSK HKRNLAITGG VTLSVIASPV IAAVSVGIGV
     PIMLAYVYGV VPISLCRGGG CGVSTANGKG VKIEFDEDDG PITVADAWRA LKNPSIGESS
     IEGLTSVLST SGSPTDGLSV MQGPYSETAS FAALSGGTLS GGILSSGKGK YSRECNNMEI
     QVDIEAKPSH YQLVSGSSTE DSLHVHAQMA ENEEEGSGGG GSEEDPPCRH QSCEQKDCLA
     SKPWDISLAQ PESIRSDLES SDTQSDDVPD ITSDECGSPR SHTAACPSTP RAQGAPSPSA
     HMNLSALAEG QTVLKPEGGE ARV
//