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Database: UniProt
Entry: A0A2K5M2B8_CERAT
LinkDB: A0A2K5M2B8_CERAT
Original site: A0A2K5M2B8_CERAT 
ID   A0A2K5M2B8_CERAT        Unreviewed;       510 AA.
AC   A0A2K5M2B8;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   10-APR-2019, entry version 8.
DE   RecName: Full=Hyaluronidase {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713};
GN   Name=SPAM1 {ECO:0000313|Ensembl:ENSCATP00000019343};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000019343, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000019343, ECO:0000313|Proteomes:UP000233060}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Liu Y., Hughes D.S., Murali S., Raveendran M., Korchina V., Wang M.,
RA   Jhangiani S., Bandaranaike D., Bellair M., Blankenburg K., Chao H.,
RA   Dahdouli M., Dinh H., Doddapaneni H., English A., Firestine M.,
RA   Gross S., Hernandez B., Javaid M., Jayaseelan J., Jones J., Joshi V.,
RA   Khan Z., Kovar C., Lee S., Newsham I., Nguyen L., Okwuonu G.,
RA   Ongeri F., Osuji N., Pu L.-L., Puazo M., Qu C., Quiroz J., Raj R.,
RA   Reid J.G., Santibanez J., Scheel M., Sexton D., Shah N., Skinner E.,
RA   Vee V., Wu Y., Han Y., Muzny D.M., Richards S., Worley K.C.,
RA   Rogers J., Gibbs R.A.;
RT   "Sooty reference genome and diversity panel.";
RL   Submitted (MAR-2015) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCATP00000019343}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (FEB-2018) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|PIRNR:PIRNR038193,
CC         ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|PIRNR:PIRNR038193, ECO:0000256|RuleBase:RU610713}.
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DR   RefSeq; XP_011943315.1; XM_012087925.1.
DR   RefSeq; XP_011943316.1; XM_012087926.1.
DR   RefSeq; XP_011943317.1; XM_012087927.1.
DR   Ensembl; ENSCATT00000043524; ENSCATP00000019343; ENSCATG00000033464.
DR   GeneID; 105598516; -.
DR   CTD; 6677; -.
DR   GeneTree; ENSGT00950000182708; -.
DR   OrthoDB; 1096692at2759; -.
DR   Proteomes; UP000233060; Whole Genome Shotgun Assembly.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-UniRule.
DR   GO; GO:0007342; P:fusion of sperm to egg plasma membrane involved in single fertilization; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   InterPro; IPR001439; Hyaluronidase_PH20/Hyal5.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PIRSF; PIRSF500773; Hyaluronidase_PH20_Hyal5; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000233060};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|PIRNR:PIRNR038193,
KW   ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|PIRNR:PIRNR038193,
KW   ECO:0000256|RuleBase:RU610713};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   ACT_SITE    148    148       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    368    368       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     60    351       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    224    238       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    376    387       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    381    435       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    437    443       {ECO:0000256|PIRSR:PIRSR038193-3}.
SQ   SEQUENCE   510 AA;  57939 MW;  C62D91647311C414 CRC64;
     MGVQKFKHIF FRSFVKSSGV SQIVFTFLLI PCCLTLNFRA PPIIPNVPFL WAWNAPSEFC
     LGKFDEPLDM SLFTLMGSPR INVTGQGVTI FYVDRLGYYP YIDLTTGVTV HGGIPQKVSL
     QDHLDKSKQD ILFYMPVDNL GMAVIDWEEW RPTWARNWKP KDVYKNRSIE LVQQQNVQLS
     LPQATDKAKQ EFEKAGKDFM LETIKLGRSL RPNHLWGYYL FPDCYNHHYR KPGYNGSCFD
     VEIKRNDDLS WLWNESTALY PSIYLNTQQS VVVATLYVRN RVREAIRVSK IPDAKNPLPV
     FVYARLVFTD QVLKFLSREE LVSTLGETVA LGASGIVIWG SLSITRSMKS CMLLDTYMET
     ILNPYIINVT LAAKMCSQVL CQEQGVCIRK DWNSSDYLHL NPDNFDIRLG KGGKFTVHGK
     PTVEDLEEFS EKFYCSCYTN LSCKEKADVK DTDAIDVCIA DGVCIDASLK PPVETEGSPP
     IFYNTSSSTV STTMFIVNIL FLIISSVVSL
//
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