ID A0A2K5M3L4_CERAT Unreviewed; 2003 AA.
AC A0A2K5M3L4;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Dedicator of cytokinesis 4 {ECO:0000313|Ensembl:ENSCATP00000019772.1};
GN Name=DOCK4 {ECO:0000313|Ensembl:ENSCATP00000019772.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000019772.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000019772.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 9531.ENSCATP00000019772; -.
DR Ensembl; ENSCATT00000043956.1; ENSCATP00000019772.1; ENSCATG00000033543.1.
DR GeneTree; ENSGT00940000155659; -.
DR OMA; MRDFGHS; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000033543; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005794; C:Golgi apparatus; IEA:Ensembl.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0032420; C:stereocilium; IEA:Ensembl.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030165; F:PDZ domain binding; IEA:Ensembl.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:Ensembl.
DR GO; GO:0031267; F:small GTPase binding; IEA:Ensembl.
DR GO; GO:0060326; P:cell chemotaxis; IEA:Ensembl.
DR GO; GO:1904694; P:negative regulation of vascular associated smooth muscle contraction; IEA:Ensembl.
DR GO; GO:1904754; P:positive regulation of vascular associated smooth muscle cell migration; IEA:Ensembl.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR CDD; cd11705; DHR2_DOCK4; 1.
DR CDD; cd12049; SH3_DOCK4_B; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037014; DHR2_DOCK4.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR035769; DOCK4_SH3.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF7; DEDICATOR OF CYTOKINESIS PROTEIN 4; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..59
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 393..566
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1227..1633
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1685..1766
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1779..2003
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1503..1530
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1685..1736
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1739..1753
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1794..1813
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1834..1911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1956..1972
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2003 AA; 229182 MW; 95CBB2A8463D87D2 CRC64;
SWVGFIASFR GTVPYGLSLE IGDTVQILEK CDGWYRGFAL KNPNIKGIFP SSYVHLKNAC
VKNKGQFEMV IPTEDSVITE MTSTLRDWGT MWKQLYVRNE GDLFHRLWHI MNEILDLRRQ
VLVGHLTHDR MKDVKRHITA RLDWGNEQLG LDLVPRKEYA MVDPEDISIT ELYRLMEHRH
RKKDTPVQAS SHHLFVQMKS LMCSNLGEEL EVIFSLFDSK ENRPISERFF LRLNRNGLPK
APDKPERHCS LFVDLGSSEL KKDIYITVHI IRIGRMGAGE KKNACSVQYR RPFGCAVLSI
ADLLTGETKD DLILKVYMCN TESEWYQIHE NIIKKLNARY NLTGSNAGLA VSLQLLHGDI
EQIRREYSSV FSHGVSITRK LGFSNIIMPG EMRNDLYITI ERGEFEKGGK SVARNVEVTM
FIVDSSGQTL KDFISFGSGE PPASEYHSFV LYHNNSPRWS ELLKLPIPVD KFRGAHIRFE
FRHCSTKEKG EKKLFGFSFV PLMQEDGRTL PDGTHELIVH KCEENTNLQD TTRYLKLPFS
KGIFLGNNNQ AMKATKESFC ITSFLCSTKL TQNGDMLDLL KWRTHPDKIT GCLSKLKEID
GSEIVKFLQD TLDTLFGILD ENSQKYGSKV FDSLVHIINL LQDSKFHHFK PVMDTYIESH
FAGALAYRDL IKVLKWYVDR ITEAERQEHI QEVLKAQEYI FKYIVQSRRL FSLATGGQNE
EEFRCCIQEL LMSVRFFLSQ ESKGSGALSQ SQAVFLSSFP AVYSELLKLF DVREVANLVQ
DTLGSLPTIL HVDDSLQAIK LQCIGKTVES QLYTNPDSRY ILLPVVLHHL HIHLQEQKDL
IMCARILSNV FCLIKKNSSE KSVLEEIDVI VASLLDILLR TILEITSRPQ PSSSAMRFQF
QDVTRTGFLN KESLHDSSTL STFSFCADTY GKVPMTGRHT GEFVACLLSL LRQMTDRHYQ
QLLDSFNTKE ELRDFLLQIF TVFRILIRPE MFPKDWTVMR LVANNVIITT VLYLSDALRK
NFLNENFDYK IWDSYFYLAV IFINQLCLQL EMFTPSKKKK VLEKYGDMRV TMGCEIFSMW
QNLGEHKLHF IPALIGPFLE VTLIPQPDLR NVMIPIFHDM MDWEQRRSGN FKQVEAKLID
KLDSLMSEGK GDETYRELFN SIIPLFGPYP SLLKKIERET WRESGVSLIA TVTRLMERLL
DYRDCMKMGE VDGKKIGCTV SLLNFYKTEL NKEEMYIRYI HKLYDLHLKA QNFTEAAYTL
LLYDELLEWS DRPLREFLTY PMQTEWQRKE HLHLTIIQNF DRGKCWENGI ILCRKIAEQY
ESYYDYRNLS KMRMMEASLY DKIMDQQRLE PEFFRVGFYG KKFPFFLRNK EFVCRGHDYE
RLEAFQQRML NEFPHAIAMQ HANQPDETIF QAEAQYLQIY AVTPIPESQE VLQREGVPDN
IKSFYKVNHI WKFRYDRPFH KGTKDKENEF KSLWVERTSL YLVQSLPGIS RWFEVEKREV
VEMSPLENAI EVLENKNQQL KTLISQCQTR QMQNINPLTM CLNGVIDAAV NGGVSRYQEA
FFVKEYILSH PEDGEKIARL RELMLEQAQI LEFGLAVHEK FVPQDMRPLH KKLVDQFFVM
KSSLGIQEFS ACMQASPVHF PNGSPRVCRN SAPASVSPDG TRVIPRRSPL SYPAVNRYSS
SSLSSQASAE VSNITGQSES SDEVFNMQPS PSTSSLSSTH SASPNVTSSA PSSARASPLL
SDKHKHSREN SCLSPRERPC SAIYPTPVEP SQRMLFNHIG DGALPRSDPN LSAPEKAVNP
TPSSWSLDSG KEAKNMSDSG KLISPPVPPR PTQTASPARH TTSVSPSPAG RSPLKGSVQS
FTPSPVEYHS PGLISNSPVL SGSYSSGISS LSRCSTSETS GFENQVNEQS VPLPVPVPVP
VPVYGGEEPV RKESKTPPPY SVYERTLRRP VPLPHSLSIP VTPEPPALPP KPLAARSSHL
ENGARRTDPG PRPRPLPRKV SQL
//
