ID A0A2K5M3M7_CERAT Unreviewed; 1927 AA.
AC A0A2K5M3M7;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Dedicator of cytokinesis 4 {ECO:0000313|Ensembl:ENSCATP00000019782.1};
GN Name=DOCK4 {ECO:0000313|Ensembl:ENSCATP00000019782.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000019782.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000019782.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR Ensembl; ENSCATT00000043966.1; ENSCATP00000019782.1; ENSCATG00000033543.1.
DR GeneTree; ENSGT00940000155659; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000033543; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08695; C2_Dock-B; 1.
DR CDD; cd11705; DHR2_DOCK4; 1.
DR CDD; cd12049; SH3_DOCK4_B; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.20.1270.350; Dedicator of cytokinesis N-terminal subdomain; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR037811; C2_Dock-B.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR037014; DHR2_DOCK4.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR035769; DOCK4_SH3.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR032376; DOCK_N.
DR InterPro; IPR042455; DOCK_N_sub1.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45653; DEDICATOR OF CYTOKINESIS; 1.
DR PANTHER; PTHR45653:SF7; DEDICATOR OF CYTOKINESIS PROTEIN 4; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF16172; DOCK_N; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 1..59
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 393..566
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1191..1597
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 1649..1730
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1743..1789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1811..1927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1467..1494
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1649..1700
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1703..1717
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1761..1789
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1811..1837
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1880..1896
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1927 AA; 221050 MW; 3838DAE652D2CE1F CRC64;
SWVGFIASFR GTVPYGLSLE IGDTVQILEK CDGWYRGFAL KNPNIKGIFP SSYVHLKNAC
VKNKGQFEMV IPTEDSVITE MTSTLRDWGT MWKQLYVRNE GDLFHRLWHI MNEILDLRRQ
VLVGHLTHDR MKDVKRHITA RLDWGNEQLG LDLVPRKEYA MVDPEDISIT ELYRLMEHRH
RKKDTPVQAS SHHLFVQMKS LMCSNLGEEL EVIFSLFDSK ENRPISERFF LRLNRNGLPK
APDKPERHCS LFVDLGSSEL KKDIYITVHI IRIGRMGAGE KKNACSVQYR RPFGCAVLSI
ADLLTGETKD DLILKVYMCN TESEWYQIHE NIIKKLNARY NLTGSNAGLA VSLQLLHGDI
EQIRREYSSV FSHGVSITRK LGFSNIIMPG EMRNDLYITI ERGEFEKGGK SVARNVEVTM
FIVDSSGQTL KDFISFGSGE PPASEYHSFV LYHNNSPRWS ELLKLPIPVD KFRGAHIRFE
FRHCSTKEKG EKKLFGFSFV PLMQEDGRTL PDGTHELIVH KCEENTNLQD TTRYLKLPFS
KGIFLGNNNQ AMKATKESFC ITSFLCSTKL TQNGDMLDLL KWRTHPDKIT GCLSKLKEID
GSEIVKFLQD TLDTLFGILD ENSQKYGSKV FDSLVHIINL LQDSKFHHFK PVMDTYIESH
FAGALAYRDL IKVLKWYVDR ITEAERQEHI QEVLKAQEYI FKYIVQSRRL FSLATGGQNE
EEFRCCIQEL LMSVRFFLSQ ESKGSGALSQ SQAVFLSSFP AVYSELLKLF DVREVANLVQ
DTLGSLPTIL HVDDSLQAIK LQCIGKTVES QLYTNPDSRY ILLPVVLHHL HIHLQEQKDL
IMCARILSNV FCLIKKNSSE KSVLEEIDVI VASLLDILLR TILEITSRPQ PSSSAMRFQF
QDVTGEFVAC LLSLLRQMTD RHYQQLLDSF NTKEELRDFL LQIFTVFRIL IRPEMFPKDW
TVMRLVANNV IITTVLYLSD ALRKNFLNEN FDYKIWDSYF YLAVIFINQL CLQLEMFTPS
KKKKVLEKYG DMRVTMGCEI FSMWQNLGEH KLHFIPALIG PFLEVTLIPQ PDLRNVMIPI
FHDMMDWEQR RSGNFKQVEA KLIDKLDSLM SEGKGDETYR ELFNSIIPLF GPYPSLLKKI
ERETWRESGV SLIATVTRLM ERLLDYRDCM KMGEVDGKKI GCTVSLLNFY KTELNKEEMY
IRYIHKLYDL HLKAQNFTEA AYTLLLYDEL LEWSDRPLRE FLTYPMQTEW QRKEHLHLTI
IQNFDRGKCW ENGIILCRKI AEQYESYYDY RNLSKMRMME ASLYDKIMDQ QRLEPEFFRV
GFYGKKFPFF LRNKEFVCRG HDYERLEAFQ QRMLNEFPHA IAMQHANQPD ETIFQAEAQY
LQIYAVTPIP ESQEVLQREG VPDNIKSFYK VNHIWKFRYD RPFHKGTKDK ENEFKSLWVE
RTSLYLVQSL PGISRWFEVE KREVVEMSPL ENAIEVLENK NQQLKTLISQ CQTRQMQNIN
PLTMCLNGVI DAAVNGGVSR YQEAFFVKEY ILSHPEDGEK IARLRELMLE QAQILEFGLA
VHEKFVPQDM RPLHKKLVDQ FFVMKSSLGI QEFSACMQAS PVHFPNGSPR VCRNSAPASV
SPDGTRVIPR RSPLSYPAVN RYSSSSLSSQ ASAEVSNITG QSESSDEVFN MQPSPSTSSL
SSTHSASPNV TSSAPSSARA SPLLSDKHKH SRENSCLSPR ERPCSAIYPT PVEPSQRMLF
NHIGDGALPR SDPNLSAPEK ASPARHTTSV SPSPAGRSPL KGSVQSFTPS PVEYHSPGLI
SNSPVLSGSY SSGISSLSRC STSETSGFEN QVNEQSVPLP VPVPVPVYGG EEPVRKESKT
PPPYSVYERT LRRPVPLPHS LSIPVTPEPP ALPPKPLAAR SSHLENGARR TDPGPRPRPL
PRKVSQL
//
