ID   A0A2K5M5M5_CERAT        Unreviewed;       336 AA.
AC   A0A2K5M5M5;
DT   28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT   28-MAR-2018, sequence version 1.
DT   24-JAN-2024, entry version 25.
DE   SubName: Full=Citramalyl-CoA lyase {ECO:0000313|Ensembl:ENSCATP00000020492.1};
GN   Name=CLYBL {ECO:0000313|Ensembl:ENSCATP00000020492.1};
OS   Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Cercocebus.
OX   NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000020492.1, ECO:0000313|Proteomes:UP000233060};
RN   [1] {ECO:0000313|Ensembl:ENSCATP00000020492.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (SEP-2023) to UniProtKB.
CC   -!- COFACTOR:
CC       Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC         Evidence={ECO:0000256|ARBA:ARBA00001946};
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DR   AlphaFoldDB; A0A2K5M5M5; -.
DR   Ensembl; ENSCATT00000044684.1; ENSCATP00000020492.1; ENSCATG00000034018.1.
DR   GeneTree; ENSGT00390000017163; -.
DR   Proteomes; UP000233060; Unplaced.
DR   Bgee; ENSCATG00000034018; Expressed in liver and 12 other cell types or tissues.
DR   GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.20.20.60; Phosphoenolpyruvate-binding domains; 1.
DR   InterPro; IPR005000; Aldolase/citrate-lyase_domain.
DR   InterPro; IPR040186; Citramalyl-CoA_lyase.
DR   InterPro; IPR011206; Citrate_lyase_beta/mcl1/mcl2.
DR   InterPro; IPR015813; Pyrv/PenolPyrv_Kinase-like_dom.
DR   InterPro; IPR040442; Pyrv_Kinase-like_dom_sf.
DR   PANTHER; PTHR11105:SF0; CITRAMALYL-COA LYASE, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR11105; CITRATE LYASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF03328; HpcH_HpaI; 1.
DR   PIRSF; PIRSF015582; Cit_lyase_B; 1.
DR   SUPFAM; SSF51621; Phosphoenolpyruvate/pyruvate domain; 1.
PE   4: Predicted;
KW   Magnesium {ECO:0000256|PIRSR:PIRSR015582-2};
KW   Metal-binding {ECO:0000256|PIRSR:PIRSR015582-2};
KW   Reference proteome {ECO:0000313|Proteomes:UP000233060}.
FT   DOMAIN          57..285
FT                   /note="HpcH/HpaI aldolase/citrate lyase"
FT                   /evidence="ECO:0000259|Pfam:PF03328"
FT   BINDING         118
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT   BINDING         182
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
FT   BINDING         182
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-1"
FT   BINDING         217
FT                   /ligand="Mg(2+)"
FT                   /ligand_id="ChEBI:CHEBI:18420"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR015582-2"
SQ   SEQUENCE   336 AA;  37202 MW;  E0A4BEA59A9752CD CRC64;
     MTVIWDLGLG KSPLSGCWQK TNLDVKEEKT EQKASLAADV PRLGYSSSSS PKYIPRRAVL
     YVPGNDEKKI KKIPSLNVDC AVLDCEDGVA ANKKNEARLR IVKTLEDFDL GPTEKCVRVN
     SVSSGLAEED LETLLQSRVL PSSLMLPKVE SPEEIQWFAD KFSFHLKGRK LEQPMNLIPF
     VETAMGLLNF KAVCEETLKI GPQVGLFLDA VVFGGEDFRA SIGATSSKET LDILYARQKI
     VVIAKAFGLQ AIDLVYIDFR DGAGLLRQSR EGAAMGFTGK QVIHPNQIAV VQEQFSPSPE
     KIKWAEELIA AFKEHQQLGK GMVRCNDHYC RVTTRG
//