ID A0A2K5M668_CERAT Unreviewed; 1997 AA.
AC A0A2K5M668;
DT 28-MAR-2018, integrated into UniProtKB/TrEMBL.
DT 28-MAR-2018, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN Name=PTPRB {ECO:0000313|Ensembl:ENSCATP00000020676.1};
OS Cercocebus atys (Sooty mangabey) (Cercocebus torquatus atys).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Cercocebus.
OX NCBI_TaxID=9531 {ECO:0000313|Ensembl:ENSCATP00000020676.1, ECO:0000313|Proteomes:UP000233060};
RN [1] {ECO:0000313|Ensembl:ENSCATP00000020676.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (SEP-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC Receptor class 3 subfamily. {ECO:0000256|ARBA:ARBA00025789}.
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DR RefSeq; XP_011905090.1; XM_012049700.1.
DR Ensembl; ENSCATT00000044868.1; ENSCATP00000020676.1; ENSCATG00000033946.1.
DR GeneID; 105581022; -.
DR CTD; 5787; -.
DR GeneTree; ENSGT00940000156088; -.
DR OMA; TRHQTNT; -.
DR OrthoDB; 5402037at2759; -.
DR Proteomes; UP000233060; Unplaced.
DR Bgee; ENSCATG00000033946; Expressed in lung and 12 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd00063; FN3; 14.
DR CDD; cd14617; R-PTPc-B; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 15.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR041201; PTPRJ_TM.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR46957; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR46957:SF2; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE BETA; 1.
DR Pfam; PF00041; fn3; 16.
DR Pfam; PF18861; PTP_tm; 1.
DR Pfam; PF00102; Y_phosphatase; 1.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 17.
DR SMART; SM00194; PTPc; 1.
DR SMART; SM00404; PTPc_motif; 1.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF49265; Fibronectin type III; 16.
DR PROSITE; PS50853; FN3; 9.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000233060};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..1997
FT /note="protein-tyrosine-phosphatase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014393983"
FT DOMAIN 113..208
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 292..379
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 470..556
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 643..734
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 735..821
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 822..912
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 995..1087
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1260..1356
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1357..1448
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1703..1963
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1878..1954
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1997 AA; 224201 MW; EFD3A3F890791E07 CRC64;
MLSHGAELAL WIALSLLQTG LAEPERCNFT LAESKASSHS VSIRWRIWGS PCNFNLTYSS
DTLGAASCPP FRLDNTTYGC NLQDLQAGTI YNFRIVSLDG EERTVVLQTD PLPPARFGVS
KEKSTSTSLH IWWTPSPGKV TSYEVQLFDE NNRKIQGVQI QESTSWNKYT FFNLTAGSKY
NITITAVSGG KHSSSVYTNG STVPSPVEDI GISTKANSLL VSWSHGSGNV ERYRLMLMDK
GILVHGSVVD RQATSYAFNG LTPGYLYNLT VVTEAAGLQN YKWKLVRTAP MEVSNLKVTN
DGSLTSLKVK WQRPPGNVDS YNITLSHKGT IKESRVLAPR VTETHFKELT PGRLYQVTVS
CGSGELSAQR MAVGRTFPDK VANLEANSNG WMRSLVVSWS PPAGDWEQYR ILLFNDSVVL
LNITVGKEET QYVMDDMGLV PGRQYEVEVI VESGNLKNPE RCQGRTVPLA VLQLRVKHAN
ETSLSIIWQP PVAEWEEYII SLADRDLRLI HKSLSKDAKE FTFTDLVPGR KYMATVTSIS
GDLKNSSSVK GRTVPAQVTD LHVANQGMTS SLFTNWTQAQ GDVEFYQVLL IHENVVIKNE
SISSEASGYS FHPLKSGSLY SVVVTTVSGG ISSRQVVVEG RTVPSSVSGV TVNNSGRNDY
LSVSWLPAPG DVDNYEVTLS HDGRVVQSLV IAKSVRECSF SSLTPGRLYT VTVTTRSGKY
ENHSFSQERT VPDKVQGVSV SNSARSDYLR VSWVHATGDF DHYEVTIKNK NNFIETKSIP
KSENECVFVQ LVPGRLYSVT VTTKSGQYEA SEQGNGRTIP EPVKDLTLRN RSTEDLHVTW
SGANGDVDQY EIQLLFNDMK VFPPFHLVNT ATEYRFTSLT PGRQYKILVL TISGDVQQSA
FIEGFTVPSA VKNIHISPNG ATDSLTVNWT PGGGDVDSYT VSAFRHSQKV DSQTVPKHIF
EHTFHRLEAG EQYQIMIASV SGSLKNQINV VGRTVPASVQ GVIADNAYSS HSLIVSWQKA
AGVAERYDIL LLTENGILHN TSEPATTKQH KFEDLIPGKK YKIQILTVSG GLFSKEAQTE
GRTVPAAVTN LRITENSTRH LSFRWTASEG ELSWYNIFLY NPDGNLQERA QVDPQVQSFS
FQNLLQGRMY KMVIVTHSGE LSNESFIFGR TVPASVSHLR GSNRNMTDSL WFSWSPASGD
FDFYELILYN PNGTKKENWK DKDLTEWRFH GLVPGRKYTL WVVTHSGDLS NKVTVESRTA
PSPPSLMSFA DIANTSLAIT WKGPPDWTDY NDFELQWLPR DALTVFNPYN NRKSEGRILY
GLRPGRSYQF SVKTVSGDSW KTYSKPIFGT VRTKPDKIQN LHCRPQNSTA IACSWIPPDS
DFDGYSIECR KMDTQEVEFS RKLEKEKSLL NIMMLVPHKR YLVSIKVQSA GMTSEVVEDS
TITMIDRPPP PPPHIRVNEK DVLISKSSIN FTVNCSWFSD TNGAVKYFTV VVREADGSDE
LKPEQQHPLP SYLEYRHNAS IRVYQTNYFA SKCAENPNSN SKSFNIKLGA EMESLGGKCD
PTQQKFCDGP LKPHTAYRIS IRAFTQLFDE DLKEFTKPLY SDTFFSLPIT TESEPLFGAI
EGVSAGLFLI GMLVAVVALL ICRQKVSHGR ERPSARLSIR RDRPLSVHLN LGQKGNRKTS
CPIKINQFEG HFMKLQADSN YLLSKEYEEL KDVGRNQSCD IALLPENRGK NRYNNILPYD
ATRVKLSNVD DDPCSDYINA SYIPGNNFRR EYIVTQGPLP GTKDDFWKMV WEQNVHNIVM
VTQCVEKGRV KCDHYWPADL DSLYYGDLIL QMLSESVLPE WTIREFKICS EEQLDAHRLI
RHFHYTVWPD HGVPETTQSL IQFVRTVRDY INRSPGAGPT VVHCSAGVGR TGTFIALDRI
LQQLDSKDSV DIYGAVHDLR LHRVHMVQTE CQYVYLHQCV RDVLRARKLR SEQENPLFPI
YENVNPEYHR DPVYSRH
//
